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Neural control of submucosal gland and apical membrane secretions in airways.

Cuthbert AW, Murthy M, Darlington AP - Physiol Rep (2015)

Bottom Line: Activation of neurones in the intrinsic nerve net by veratrine alkaloids caused an immediate increase in both glandular secretion and short circuit current, both effects being blocked by the addition of tetrodotoxin.The toxin alone had no discernable effect on the low-level basal secretion shown by unstimulated glands.Calu-3 cell monolayers, generally agreed to be a surrogate for the secretory cells of submucosal glands, showed no sensitivity to veratrine alkaloids, strengthening the view that the veratrine-like drugs acted exclusively on the intrinsic nerve net.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, University of Cambridge, Cambridge, UK awc1000@hermes.cam.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Submucosal gland secretion in response to veratridine. The figure shows the secretion volumes versus time for six separate glands (A), the mean secretion volumes for all glands (B), and the mean secretion rates for all glands (C).
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fig02: Submucosal gland secretion in response to veratridine. The figure shows the secretion volumes versus time for six separate glands (A), the mean secretion volumes for all glands (B), and the mean secretion rates for all glands (C).

Mentions: Figure2A, B, and C shows data from an experiment in which veratridine was used to stimulate submucosal gland secretion. The results again take the form found with veratrine and in no experimental condition did we discover characteristics that could differentiate veratrine from veratridine.


Neural control of submucosal gland and apical membrane secretions in airways.

Cuthbert AW, Murthy M, Darlington AP - Physiol Rep (2015)

Submucosal gland secretion in response to veratridine. The figure shows the secretion volumes versus time for six separate glands (A), the mean secretion volumes for all glands (B), and the mean secretion rates for all glands (C).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4510617&req=5

fig02: Submucosal gland secretion in response to veratridine. The figure shows the secretion volumes versus time for six separate glands (A), the mean secretion volumes for all glands (B), and the mean secretion rates for all glands (C).
Mentions: Figure2A, B, and C shows data from an experiment in which veratridine was used to stimulate submucosal gland secretion. The results again take the form found with veratrine and in no experimental condition did we discover characteristics that could differentiate veratrine from veratridine.

Bottom Line: Activation of neurones in the intrinsic nerve net by veratrine alkaloids caused an immediate increase in both glandular secretion and short circuit current, both effects being blocked by the addition of tetrodotoxin.The toxin alone had no discernable effect on the low-level basal secretion shown by unstimulated glands.Calu-3 cell monolayers, generally agreed to be a surrogate for the secretory cells of submucosal glands, showed no sensitivity to veratrine alkaloids, strengthening the view that the veratrine-like drugs acted exclusively on the intrinsic nerve net.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, University of Cambridge, Cambridge, UK awc1000@hermes.cam.ac.uk.

No MeSH data available.


Related in: MedlinePlus