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Quantifying the broader economic consequences of quadrivalent human papillomavirus (HPV) vaccination in Germany applying a government perspective framework.

Kotsopoulos N, Connolly MP, Remy V - Health Econ Rev (2015)

Bottom Line: A cohort model was developed simulating the medical costs and average lifetime fiscal transfers between the government and 12-year-old immunized and non-immunized males and females.To estimate tax revenue attributed to vaccination-related changes in morbidity and mortality, direct and indirect tax rates were linked to differences in age- and gender-specific earnings.The vaccination of males and females with the quadrivalent HPV vaccine is likely to have positive effects on public finances.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Unit of PharmacoEpidemiology & PharmacoEconomics, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

ABSTRACT
HPV infections can cause substantial burden in females and males as it is associated with several genital cancers, in addition to genital warts. Traditional economic evaluations often focus on quantifying cost-effectiveness, however, it is increasingly recognized that vaccinations may generate broader benefits not captured in cost-effectiveness analysis. Τhe aim of this study was to evaluate the broader economic consequences associated with HPV vaccination in males and females and to conduct a lifetime cost-benefit analysis of investing in universal vaccination in Germany from the perspective of government. Methodologies from generational accounting, human capital and health economics were combined to estimate the broader economic consequences of HPV vaccination including the fiscal impact for the government. A cohort model was developed simulating the medical costs and average lifetime fiscal transfers between the government and 12-year-old immunized and non-immunized males and females. To estimate tax revenue attributed to vaccination-related changes in morbidity and mortality, direct and indirect tax rates were linked to differences in age- and gender-specific earnings. Based on HPV vaccination costs, the base case cost-benefit analysis demonstrated that investing 1 in universal HPV vaccination could yield 1.7 in gross tax revenue over the lifetime of the cohorts. After taking into consideration the governmental transfers, universal HPV vaccination in Germany could result in incremental positive net discounted taxes (i.e. tax revenue-transfers) from 62 million for the German government. The vaccination of males and females with the quadrivalent HPV vaccine is likely to have positive effects on public finances.

No MeSH data available.


Related in: MedlinePlus

One-way sensitivity and scenario analyses for the fiscal BCR
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Related In: Results  -  Collection

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Fig2: One-way sensitivity and scenario analyses for the fiscal BCR

Mentions: We hereby present the tornado diagrams (Fig. 2) for the most sensitive parameters and the scenarios run, for the fiscal or gross tax based CBA. The results of the sensitivity analysis suggested that a number of economic variables were associated with high sensitivity however; the BCR consistently remained above 1 except in one scenario. One noteworthy finding was the influence of the incidence of GW which, highlights the economic importance of this outcome. The reason for the high sensitivity may relate to the high incidence of GW as well as the accumulation of most GW cases in early years of life. Since this is a discounted flows’ analysis, the selection of discount rate has a high impact on the final results as well as the rate for inflating medical and other costs in the future.Fig. 2


Quantifying the broader economic consequences of quadrivalent human papillomavirus (HPV) vaccination in Germany applying a government perspective framework.

Kotsopoulos N, Connolly MP, Remy V - Health Econ Rev (2015)

One-way sensitivity and scenario analyses for the fiscal BCR
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4510306&req=5

Fig2: One-way sensitivity and scenario analyses for the fiscal BCR
Mentions: We hereby present the tornado diagrams (Fig. 2) for the most sensitive parameters and the scenarios run, for the fiscal or gross tax based CBA. The results of the sensitivity analysis suggested that a number of economic variables were associated with high sensitivity however; the BCR consistently remained above 1 except in one scenario. One noteworthy finding was the influence of the incidence of GW which, highlights the economic importance of this outcome. The reason for the high sensitivity may relate to the high incidence of GW as well as the accumulation of most GW cases in early years of life. Since this is a discounted flows’ analysis, the selection of discount rate has a high impact on the final results as well as the rate for inflating medical and other costs in the future.Fig. 2

Bottom Line: A cohort model was developed simulating the medical costs and average lifetime fiscal transfers between the government and 12-year-old immunized and non-immunized males and females.To estimate tax revenue attributed to vaccination-related changes in morbidity and mortality, direct and indirect tax rates were linked to differences in age- and gender-specific earnings.The vaccination of males and females with the quadrivalent HPV vaccine is likely to have positive effects on public finances.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Unit of PharmacoEpidemiology & PharmacoEconomics, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

ABSTRACT
HPV infections can cause substantial burden in females and males as it is associated with several genital cancers, in addition to genital warts. Traditional economic evaluations often focus on quantifying cost-effectiveness, however, it is increasingly recognized that vaccinations may generate broader benefits not captured in cost-effectiveness analysis. Τhe aim of this study was to evaluate the broader economic consequences associated with HPV vaccination in males and females and to conduct a lifetime cost-benefit analysis of investing in universal vaccination in Germany from the perspective of government. Methodologies from generational accounting, human capital and health economics were combined to estimate the broader economic consequences of HPV vaccination including the fiscal impact for the government. A cohort model was developed simulating the medical costs and average lifetime fiscal transfers between the government and 12-year-old immunized and non-immunized males and females. To estimate tax revenue attributed to vaccination-related changes in morbidity and mortality, direct and indirect tax rates were linked to differences in age- and gender-specific earnings. Based on HPV vaccination costs, the base case cost-benefit analysis demonstrated that investing 1 in universal HPV vaccination could yield 1.7 in gross tax revenue over the lifetime of the cohorts. After taking into consideration the governmental transfers, universal HPV vaccination in Germany could result in incremental positive net discounted taxes (i.e. tax revenue-transfers) from 62 million for the German government. The vaccination of males and females with the quadrivalent HPV vaccine is likely to have positive effects on public finances.

No MeSH data available.


Related in: MedlinePlus