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Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses.

Calvo C, García-García ML, Sanchez-Dehesa R, Román C, Tabares A, Pozo F, Casas I - PLoS ONE (2015)

Bottom Line: We genotyped 154 HAdVs.A total of 262 children had fever (64.9%); 194 suffered hypoxia (48%), and 147 presented infiltrate in chest x-rays (36.4%).The most frequent diagnoses were recurrent wheezing or asthma (51.7%), bronchiolitis (18.3 %), and pneumonia (11.9%), and 46 (11.4%) episodes required prolonged hospitalization (>7 days) due to the severity.

View Article: PubMed Central - PubMed

Affiliation: Pediatrics Department, Severo Ochoa Hospital, Leganés, Madrid, Spain.

ABSTRACT
Human adenovirus (HAdV) cause upper and lower respiratory tract infections. However, there are few large prospective studies focused on HAdVs acute infections requiring hospitalization. From 2005 to 2013 a prospective study was conducted on children admitted with acute respiratory infections. Specimens of nasopharyngeal aspirate were taken for virological study by PCR and clinical data was recorded. HAdV specimens were genotyped. Frequency and clinical course of HAdV infections were compared with RSV, rhinovirus (RV), human bocavirus (HBoV) and influenza in the same population. HAdV was detected in 403 cases of 2371 confirmed viral infections (17.2%) , of which 154 were single virus infections (38%). We genotyped 154 HAdVs. The most frequent genotypes were HAdV-3 (24%), HAdV-6 (21%), and HAdV-5 (20%). A total of 262 children had fever (64.9%); 194 suffered hypoxia (48%), and 147 presented infiltrate in chest x-rays (36.4%). The most frequent diagnoses were recurrent wheezing or asthma (51.7%), bronchiolitis (18.3 %), and pneumonia (11.9%), and 46 (11.4%) episodes required prolonged hospitalization (>7 days) due to the severity. Adenovirus single infections were compared with single infections of 598 RSV, 494 RV, 83 influenza and 78 HBoV. Significant clinical differences were found between HAdV, RSV and RV infections.

No MeSH data available.


Related in: MedlinePlus

Frequency of adenovirus genotypes in respiratory infections inhospitalized children.
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pone.0132162.g002: Frequency of adenovirus genotypes in respiratory infections inhospitalized children.

Mentions: Between 2005 and 2008 a total of 154 adenoviruses (154 episodes) were genotyped,corresponding to 80% of adenoviruses detected in this period (Fig 2). The most frequentgenotypes identified were HAdV-3 (24%) and HAdV-6 (21%) followed by HAdV-5 (20%)and HAdV-2 (19%). Genotype HAdV- 7 was only detected in one patient. Genotypedistribution was different between cases with single or multiple viraldetection. Genotype HAdV-3 was more frequent among patients with singleinfection, and was present in 37.3% of them (p = 0.003).


Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses.

Calvo C, García-García ML, Sanchez-Dehesa R, Román C, Tabares A, Pozo F, Casas I - PLoS ONE (2015)

Frequency of adenovirus genotypes in respiratory infections inhospitalized children.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4509737&req=5

pone.0132162.g002: Frequency of adenovirus genotypes in respiratory infections inhospitalized children.
Mentions: Between 2005 and 2008 a total of 154 adenoviruses (154 episodes) were genotyped,corresponding to 80% of adenoviruses detected in this period (Fig 2). The most frequentgenotypes identified were HAdV-3 (24%) and HAdV-6 (21%) followed by HAdV-5 (20%)and HAdV-2 (19%). Genotype HAdV- 7 was only detected in one patient. Genotypedistribution was different between cases with single or multiple viraldetection. Genotype HAdV-3 was more frequent among patients with singleinfection, and was present in 37.3% of them (p = 0.003).

Bottom Line: We genotyped 154 HAdVs.A total of 262 children had fever (64.9%); 194 suffered hypoxia (48%), and 147 presented infiltrate in chest x-rays (36.4%).The most frequent diagnoses were recurrent wheezing or asthma (51.7%), bronchiolitis (18.3 %), and pneumonia (11.9%), and 46 (11.4%) episodes required prolonged hospitalization (>7 days) due to the severity.

View Article: PubMed Central - PubMed

Affiliation: Pediatrics Department, Severo Ochoa Hospital, Leganés, Madrid, Spain.

ABSTRACT
Human adenovirus (HAdV) cause upper and lower respiratory tract infections. However, there are few large prospective studies focused on HAdVs acute infections requiring hospitalization. From 2005 to 2013 a prospective study was conducted on children admitted with acute respiratory infections. Specimens of nasopharyngeal aspirate were taken for virological study by PCR and clinical data was recorded. HAdV specimens were genotyped. Frequency and clinical course of HAdV infections were compared with RSV, rhinovirus (RV), human bocavirus (HBoV) and influenza in the same population. HAdV was detected in 403 cases of 2371 confirmed viral infections (17.2%) , of which 154 were single virus infections (38%). We genotyped 154 HAdVs. The most frequent genotypes were HAdV-3 (24%), HAdV-6 (21%), and HAdV-5 (20%). A total of 262 children had fever (64.9%); 194 suffered hypoxia (48%), and 147 presented infiltrate in chest x-rays (36.4%). The most frequent diagnoses were recurrent wheezing or asthma (51.7%), bronchiolitis (18.3 %), and pneumonia (11.9%), and 46 (11.4%) episodes required prolonged hospitalization (>7 days) due to the severity. Adenovirus single infections were compared with single infections of 598 RSV, 494 RV, 83 influenza and 78 HBoV. Significant clinical differences were found between HAdV, RSV and RV infections.

No MeSH data available.


Related in: MedlinePlus