Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
Bottom Line: Polychlorinated biphenyls (PCBs) are a group of man-made environmental pollutants which accumulate in humans with adverse health effects.In our study, we found plasma levels of four lower-chlorinated PCBs to be significantly associated with the genetic region mapping to the CYP2B6 locus.These findings show that CYP2B6 is of importance for the metabolism of PCBs in humans, and may help to identify individuals who may be susceptible to PCB toxicity.
Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. Electronic address: firstname.lastname@example.org.Show MeSH
Related in: MedlinePlus
Mentions: Following imputation, a total of 8,736,858 high-quality SNPs with MAF >1% were included in the analysis. The genomic control inflation factor for each PCB congener was close to 1 (Table 1), so no additional correction for residual population structure after adjustment for principal components was required. We identified genome-wide significant evidence of association for plasma levels of PCB-99, mapping to CYP2B6. The SNP with the strongest association signal was rs8109848 (β=0.34, SE=0.05, p=3.7×10−13), which maps to an intronic region of CYP2B6 (Fig. 1 and 2, Supplemental Tables S1 and S2). This SNP also showed weaker association with several other PCBs (Supplemental Table S3) including PCB-138 (p=3.0×10−8) and PCB-153 (p=0.000041). Conditional analyses, including the genotype dosage of rs8109848 as a covariate in the regression model, extinguished the association signal for all PCBs at this locus.
Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. Electronic address: email@example.com.