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Pathophysiology of LV Remodeling in Survivors of STEMI: Inflammation, Remote Myocardium, and Prognosis.

Carrick D, Haig C, Rauhalammi S, Ahmed N, Mordi I, McEntegart M, Petrie MC, Eteiba H, Lindsay M, Watkins S, Hood S, Davie A, Mahrous A, Sattar N, Welsh P, Tzemos N, Radjenovic A, Ford I, Oldroyd KG, Berry C - JACC Cardiovasc Imaging (2015)

Bottom Line: Remote T1 at baseline was associated with log N-terminal pro-B-type natriuretic peptide at 6 months (0.01; 95% CI: 0.00 to 0.02; p = 0.002; n = 151) and the change in LV end-diastolic volume from baseline to 6 months (0.13; 95% CI: 0.01 to 0.24; p = 0.035).Remote zone native T1 was independently associated with post-discharge major adverse cardiac events (n = 20 events; hazard ratio: 1.016; 95% CI: 1.000 to 1.032; p = 0.048) and all-cause death or heart failure hospitalization (n = 30 events during admission and post-discharge; hazard ratio: 1.014; 95% CI: 1.000 to 1.028; p = 0.049).Reperfusion injury and inflammation early post-MI was associated with remote zone T1, which in turn was independently associated with LV remodeling and adverse cardiac events post-STEMI. (Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction [BHF MR-MI]; NCT02072850).

View Article: PubMed Central - PubMed

Affiliation: BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom.

No MeSH data available.


Related in: MedlinePlus

Remote Zone Native T1 and NT-proBNP 6 Months Post-MIRemote zone native T1 (ms) at baseline was associated with N-terminal pro–B-type natriuretic peptide (NT-proBNP) (median [interquartile range]) after 6 months (n = 151 patients with ST-segment elevation myocardial infarction) (Online Appendix). MI = myocardial infarction.
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fig3: Remote Zone Native T1 and NT-proBNP 6 Months Post-MIRemote zone native T1 (ms) at baseline was associated with N-terminal pro–B-type natriuretic peptide (NT-proBNP) (median [interquartile range]) after 6 months (n = 151 patients with ST-segment elevation myocardial infarction) (Online Appendix). MI = myocardial infarction.

Mentions: Remote zone native T1 and NT-proBNP levels were not associated at baseline. By contrast, the concentrations of NT-proBNP at 6 months differed between the lowest versus highest tertiles of remote zone native T1 at baseline (Figure 3). This relationship remained after adjustment for LV ejection fraction and volumes. Specifically, remote zone native T1 at baseline in tertiles (lowest tertile = reference; intermediate tertile p = 0.145; upper tertile p = 0.013) was associated with log NT-proBNP at 6 months after adjustment for NT-proBNP at baseline (0.01 on log scale; 95% CI: 0.00 to 0.02; p = 0.049), independently of LV ejection fraction (p = 0.064) and LV end-diastolic volume at baseline (p = 0.046) (Figure 3).


Pathophysiology of LV Remodeling in Survivors of STEMI: Inflammation, Remote Myocardium, and Prognosis.

Carrick D, Haig C, Rauhalammi S, Ahmed N, Mordi I, McEntegart M, Petrie MC, Eteiba H, Lindsay M, Watkins S, Hood S, Davie A, Mahrous A, Sattar N, Welsh P, Tzemos N, Radjenovic A, Ford I, Oldroyd KG, Berry C - JACC Cardiovasc Imaging (2015)

Remote Zone Native T1 and NT-proBNP 6 Months Post-MIRemote zone native T1 (ms) at baseline was associated with N-terminal pro–B-type natriuretic peptide (NT-proBNP) (median [interquartile range]) after 6 months (n = 151 patients with ST-segment elevation myocardial infarction) (Online Appendix). MI = myocardial infarction.
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Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4509710&req=5

fig3: Remote Zone Native T1 and NT-proBNP 6 Months Post-MIRemote zone native T1 (ms) at baseline was associated with N-terminal pro–B-type natriuretic peptide (NT-proBNP) (median [interquartile range]) after 6 months (n = 151 patients with ST-segment elevation myocardial infarction) (Online Appendix). MI = myocardial infarction.
Mentions: Remote zone native T1 and NT-proBNP levels were not associated at baseline. By contrast, the concentrations of NT-proBNP at 6 months differed between the lowest versus highest tertiles of remote zone native T1 at baseline (Figure 3). This relationship remained after adjustment for LV ejection fraction and volumes. Specifically, remote zone native T1 at baseline in tertiles (lowest tertile = reference; intermediate tertile p = 0.145; upper tertile p = 0.013) was associated with log NT-proBNP at 6 months after adjustment for NT-proBNP at baseline (0.01 on log scale; 95% CI: 0.00 to 0.02; p = 0.049), independently of LV ejection fraction (p = 0.064) and LV end-diastolic volume at baseline (p = 0.046) (Figure 3).

Bottom Line: Remote T1 at baseline was associated with log N-terminal pro-B-type natriuretic peptide at 6 months (0.01; 95% CI: 0.00 to 0.02; p = 0.002; n = 151) and the change in LV end-diastolic volume from baseline to 6 months (0.13; 95% CI: 0.01 to 0.24; p = 0.035).Remote zone native T1 was independently associated with post-discharge major adverse cardiac events (n = 20 events; hazard ratio: 1.016; 95% CI: 1.000 to 1.032; p = 0.048) and all-cause death or heart failure hospitalization (n = 30 events during admission and post-discharge; hazard ratio: 1.014; 95% CI: 1.000 to 1.028; p = 0.049).Reperfusion injury and inflammation early post-MI was associated with remote zone T1, which in turn was independently associated with LV remodeling and adverse cardiac events post-STEMI. (Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction [BHF MR-MI]; NCT02072850).

View Article: PubMed Central - PubMed

Affiliation: BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom.

No MeSH data available.


Related in: MedlinePlus