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Fine Needle Aspiration Cytology of Chondroid Tenosynovial Giant Cell Tumor of the Hand.

Abdou AG, Aiad H, Youssef Asaad N - Rare Tumors (2015)

Bottom Line: Giant cell tumor (GCT) of tendon sheath is a localized form of tenosynovial GCT, which preferentially affects the joints of hands and feet.Chondroid metaplasia is a rare phenomenon in tenosynovial GCT either in localized or diffuse types.The current case investigates the cytological and histopathological features of chondroid GCT of tendon sheath in a 22-year-old female presenting with wrist swelling.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Menofiya University , Shebein Elkom, Egypt.

ABSTRACT
Giant cell tumor (GCT) of tendon sheath is a localized form of tenosynovial GCT, which preferentially affects the joints of hands and feet. Chondroid metaplasia is a rare phenomenon in tenosynovial GCT either in localized or diffuse types. The current case investigates the cytological and histopathological features of chondroid GCT of tendon sheath in a 22-year-old female presenting with wrist swelling.

No MeSH data available.


Related in: MedlinePlus

A) Mixture of proliferated mononuclear stromal cell, some of them were haemosirin laden and osteoclast multinucleated giant cells (Hematoxylin and Eosin staining 400×). B) Sheets of xanthoma cells and haemosidrin laden macrophages were also seen (Hematoxylin and Eosin staining 200×). C) Islands of metaplastic benign cartilage were detected intervening the fibrohistiocytic lesion (Hematoxylin and Eosin staining 200×).
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fig002: A) Mixture of proliferated mononuclear stromal cell, some of them were haemosirin laden and osteoclast multinucleated giant cells (Hematoxylin and Eosin staining 400×). B) Sheets of xanthoma cells and haemosidrin laden macrophages were also seen (Hematoxylin and Eosin staining 200×). C) Islands of metaplastic benign cartilage were detected intervening the fibrohistiocytic lesion (Hematoxylin and Eosin staining 200×).

Mentions: The stromal cells were mainly polygonal with abundant cytoplasm with occasional nuclear grooving (Figure 1A) and intracytoplasmic inclusions (Figure 1C). The lesion at this time was diagnosed as benign fibrohistiocytic lesion. Excision of the mass was done and the received mass was lobulated, whitish and measured 3×2×1 cm. Histological examination of excised mass revealed nodular growth formed of mononuclear and multinucleated histiocytes (Figure 2A) together with sheets of xanthoma cells and hemosidrin laden macrophages (Figure 2B). Metaplastic benign looking cartilaginous areas were also seen (Figure 2C). There was no evidence of atypia, necrosis or mitoses.


Fine Needle Aspiration Cytology of Chondroid Tenosynovial Giant Cell Tumor of the Hand.

Abdou AG, Aiad H, Youssef Asaad N - Rare Tumors (2015)

A) Mixture of proliferated mononuclear stromal cell, some of them were haemosirin laden and osteoclast multinucleated giant cells (Hematoxylin and Eosin staining 400×). B) Sheets of xanthoma cells and haemosidrin laden macrophages were also seen (Hematoxylin and Eosin staining 200×). C) Islands of metaplastic benign cartilage were detected intervening the fibrohistiocytic lesion (Hematoxylin and Eosin staining 200×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508644&req=5

fig002: A) Mixture of proliferated mononuclear stromal cell, some of them were haemosirin laden and osteoclast multinucleated giant cells (Hematoxylin and Eosin staining 400×). B) Sheets of xanthoma cells and haemosidrin laden macrophages were also seen (Hematoxylin and Eosin staining 200×). C) Islands of metaplastic benign cartilage were detected intervening the fibrohistiocytic lesion (Hematoxylin and Eosin staining 200×).
Mentions: The stromal cells were mainly polygonal with abundant cytoplasm with occasional nuclear grooving (Figure 1A) and intracytoplasmic inclusions (Figure 1C). The lesion at this time was diagnosed as benign fibrohistiocytic lesion. Excision of the mass was done and the received mass was lobulated, whitish and measured 3×2×1 cm. Histological examination of excised mass revealed nodular growth formed of mononuclear and multinucleated histiocytes (Figure 2A) together with sheets of xanthoma cells and hemosidrin laden macrophages (Figure 2B). Metaplastic benign looking cartilaginous areas were also seen (Figure 2C). There was no evidence of atypia, necrosis or mitoses.

Bottom Line: Giant cell tumor (GCT) of tendon sheath is a localized form of tenosynovial GCT, which preferentially affects the joints of hands and feet.Chondroid metaplasia is a rare phenomenon in tenosynovial GCT either in localized or diffuse types.The current case investigates the cytological and histopathological features of chondroid GCT of tendon sheath in a 22-year-old female presenting with wrist swelling.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Menofiya University , Shebein Elkom, Egypt.

ABSTRACT
Giant cell tumor (GCT) of tendon sheath is a localized form of tenosynovial GCT, which preferentially affects the joints of hands and feet. Chondroid metaplasia is a rare phenomenon in tenosynovial GCT either in localized or diffuse types. The current case investigates the cytological and histopathological features of chondroid GCT of tendon sheath in a 22-year-old female presenting with wrist swelling.

No MeSH data available.


Related in: MedlinePlus