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Breast Metastasis from Medullary Thyroid Carcinoma in a Male Patient: Case Report and Review of the Literature.

Mandanas S, Margaritidou E, Christoforidou V, Karoglou E, Geranou C, Chrisoulidou A, Boudina M, Georgopoulos K, Pazaitou-Panayiotou K - Rare Tumors (2015)

Bottom Line: Due to the extension of the disease, treatment with vandetanib was decided, but serious adverse events led to its interruption after two weeks.Core needle biopsy and histological examination of the specimen confirmed the presence of metastatic MTC.Histological and/or cytopathological examination are requisite diagnostic tools, while external beam irradiation and tyrosine kinase inhibitors may be used as palliative therapies in the concurrent presence of breast metastases from MTC.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Theagenio Cancer Hospital , Thessaloniki, Greece.

ABSTRACT
Medullary thyroid carcinoma (MTC) is a rare malignancy that may metastasize to liver, lungs and bones. Breast is an unusual metastatic site for MTC and only 20 female cases have been reported in the literature. We present a male patient in whom histological examination and immunohistochemistry of a breast mass were indicative of breast metastasis from MTC. A 67-year-old man with recent diagnosis of MTC and metastases to cervical and upper mediastinum lymph nodes was referred to our department for further treatment. At first evaluation, diagnostic imaging techniques showed lung and bone metastases and three months later the presence of liver metastases. Due to the extension of the disease, treatment with vandetanib was decided, but serious adverse events led to its interruption after two weeks. During follow-up, patient developed a painful swelling in the right breast. Ultrasound and mammography showed the presence of multiple masses to the right breast suspicious for malignancy. Core needle biopsy and histological examination of the specimen confirmed the presence of metastatic MTC. Palliative external beam irradiation was used to relieve local pain and, after one month, the patient died. Consequently, breast masses should be cautiously evaluated, mainly in the presence of a known primary malignancy. Histological and/or cytopathological examination are requisite diagnostic tools, while external beam irradiation and tyrosine kinase inhibitors may be used as palliative therapies in the concurrent presence of breast metastases from MTC.

No MeSH data available.


Related in: MedlinePlus

A hypoechoic mass with lobular appearance and hyperechoic diaphragms on ultrasound examination (A). Doppler examination reveals internal vascularity of the mass (B).
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fig002: A hypoechoic mass with lobular appearance and hyperechoic diaphragms on ultrasound examination (A). Doppler examination reveals internal vascularity of the mass (B).

Mentions: During follow-up, the patient presented a painful swelling in the right breast. He had a diagnostic mammography. Both craniocaudal and mediolateraloblique views showed bilateral breast enlargement and the presence of well circumscribed lesions mainly in the right breast (Figure 1). Ultrasound examination of the breast revealed a hypoechoic, almost homogeneous mass, with lobular appearance and well defined borders. The mass had hyperechoic diaphragms and occupied most of the right breast. No calcifications or acoustic shadowing were found (Figure 2).


Breast Metastasis from Medullary Thyroid Carcinoma in a Male Patient: Case Report and Review of the Literature.

Mandanas S, Margaritidou E, Christoforidou V, Karoglou E, Geranou C, Chrisoulidou A, Boudina M, Georgopoulos K, Pazaitou-Panayiotou K - Rare Tumors (2015)

A hypoechoic mass with lobular appearance and hyperechoic diaphragms on ultrasound examination (A). Doppler examination reveals internal vascularity of the mass (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508642&req=5

fig002: A hypoechoic mass with lobular appearance and hyperechoic diaphragms on ultrasound examination (A). Doppler examination reveals internal vascularity of the mass (B).
Mentions: During follow-up, the patient presented a painful swelling in the right breast. He had a diagnostic mammography. Both craniocaudal and mediolateraloblique views showed bilateral breast enlargement and the presence of well circumscribed lesions mainly in the right breast (Figure 1). Ultrasound examination of the breast revealed a hypoechoic, almost homogeneous mass, with lobular appearance and well defined borders. The mass had hyperechoic diaphragms and occupied most of the right breast. No calcifications or acoustic shadowing were found (Figure 2).

Bottom Line: Due to the extension of the disease, treatment with vandetanib was decided, but serious adverse events led to its interruption after two weeks.Core needle biopsy and histological examination of the specimen confirmed the presence of metastatic MTC.Histological and/or cytopathological examination are requisite diagnostic tools, while external beam irradiation and tyrosine kinase inhibitors may be used as palliative therapies in the concurrent presence of breast metastases from MTC.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Theagenio Cancer Hospital , Thessaloniki, Greece.

ABSTRACT
Medullary thyroid carcinoma (MTC) is a rare malignancy that may metastasize to liver, lungs and bones. Breast is an unusual metastatic site for MTC and only 20 female cases have been reported in the literature. We present a male patient in whom histological examination and immunohistochemistry of a breast mass were indicative of breast metastasis from MTC. A 67-year-old man with recent diagnosis of MTC and metastases to cervical and upper mediastinum lymph nodes was referred to our department for further treatment. At first evaluation, diagnostic imaging techniques showed lung and bone metastases and three months later the presence of liver metastases. Due to the extension of the disease, treatment with vandetanib was decided, but serious adverse events led to its interruption after two weeks. During follow-up, patient developed a painful swelling in the right breast. Ultrasound and mammography showed the presence of multiple masses to the right breast suspicious for malignancy. Core needle biopsy and histological examination of the specimen confirmed the presence of metastatic MTC. Palliative external beam irradiation was used to relieve local pain and, after one month, the patient died. Consequently, breast masses should be cautiously evaluated, mainly in the presence of a known primary malignancy. Histological and/or cytopathological examination are requisite diagnostic tools, while external beam irradiation and tyrosine kinase inhibitors may be used as palliative therapies in the concurrent presence of breast metastases from MTC.

No MeSH data available.


Related in: MedlinePlus