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CD10 Positive Recurrent Undifferentiated Mammary Sarcoma in a Young Female: A Rare Case Report with Brief Review of Literature.

Varma K, Gupta P, Das P, Singh P, Misra V - Rare Tumors (2015)

Bottom Line: Large area of necrosis and hemorrhage was present, too.No breast glands were found.Later on, diagnosis was confirmed on immunohistochemical examination.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Moti Lal Nehru Medical College , Allahabad, Uttar Pradesh, India.

ABSTRACT
Undifferentiated mammary sarcoma is extremely rare and the diagnosis is made only after exclusion of metaplastic carcinomas and malignant phyllodes tumor. Mammary sarcomas mostly display specified entities like liposarcomas or angiosarcomas. A 18-year-old female presented in 2010 with a right breast lump for which lumpectomy was done and on histopathological examination benign phyllodes tumor was diagnosed. In 2011, there was a recurrence at site of excised margin and on fine needle aspiration (FNA) the diagnosis of benign breast disease was made; a small biopsy was received for which diagnosis of myoepithelial lesion was given. Then, the whole mass was excised, but histopathological examination report could not be followed up. In 2013, she again presented with a mass arising from the previously excised margin; on FNA, it was diagnosed as malignant sarcomatous lesion. Microscopy showed spindle shaped cells in diffuse and fascicular pattern with plump ovoid nuclei; coarse chromatin and eosinophilic cytoplasm were seen. Few round to ovoid cells with eccentric nuclei and showing bi- or multi-nucleation were present. Large area of necrosis and hemorrhage was present, too. No breast glands were found. Later on, diagnosis was confirmed on immunohistochemical examination. The case was considered worth due to the young age of the patient and lack of differentiation of the lesion in any specific type of sarcoma and CD10 positivity.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemical findings. Tumor cells show (A) strong CD 10 positivity (B) Vimentin diffusely positive (C) EGFR strongly and diffusely positive (D) CD 34 positivity around the blood vessels and negative in tumor cells.
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fig002: Immunohistochemical findings. Tumor cells show (A) strong CD 10 positivity (B) Vimentin diffusely positive (C) EGFR strongly and diffusely positive (D) CD 34 positivity around the blood vessels and negative in tumor cells.

Mentions: On the basis of cytohistomorphological features, differential diagnosis considered were: MPT, UMS, nodular fasciitis (NF), metaplastic carcinoma (MC), myoepithelial carcinoma (MEC) and leiomyosarcoma (LMS). A large panel of antibody were used for immunohistochemistry (IHC) for further differentiation. The clone, antibody dilution and source of antibody are shown in Table 1. As seen in Table 2, only CD10 (15-30%), vimentin (70-80%), EGFR (60-70%) (Figure 2A-C) and Ki67(15-30%) were positive in present case. CD34 showed positivity around blood vessels whereas it was negative in tumor cells. On the basis of clinical presentation, cytology, histology and IHC (Table 2) a final diagnosis of CD10 positive UMS was made.


CD10 Positive Recurrent Undifferentiated Mammary Sarcoma in a Young Female: A Rare Case Report with Brief Review of Literature.

Varma K, Gupta P, Das P, Singh P, Misra V - Rare Tumors (2015)

Immunohistochemical findings. Tumor cells show (A) strong CD 10 positivity (B) Vimentin diffusely positive (C) EGFR strongly and diffusely positive (D) CD 34 positivity around the blood vessels and negative in tumor cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508640&req=5

fig002: Immunohistochemical findings. Tumor cells show (A) strong CD 10 positivity (B) Vimentin diffusely positive (C) EGFR strongly and diffusely positive (D) CD 34 positivity around the blood vessels and negative in tumor cells.
Mentions: On the basis of cytohistomorphological features, differential diagnosis considered were: MPT, UMS, nodular fasciitis (NF), metaplastic carcinoma (MC), myoepithelial carcinoma (MEC) and leiomyosarcoma (LMS). A large panel of antibody were used for immunohistochemistry (IHC) for further differentiation. The clone, antibody dilution and source of antibody are shown in Table 1. As seen in Table 2, only CD10 (15-30%), vimentin (70-80%), EGFR (60-70%) (Figure 2A-C) and Ki67(15-30%) were positive in present case. CD34 showed positivity around blood vessels whereas it was negative in tumor cells. On the basis of clinical presentation, cytology, histology and IHC (Table 2) a final diagnosis of CD10 positive UMS was made.

Bottom Line: Large area of necrosis and hemorrhage was present, too.No breast glands were found.Later on, diagnosis was confirmed on immunohistochemical examination.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Moti Lal Nehru Medical College , Allahabad, Uttar Pradesh, India.

ABSTRACT
Undifferentiated mammary sarcoma is extremely rare and the diagnosis is made only after exclusion of metaplastic carcinomas and malignant phyllodes tumor. Mammary sarcomas mostly display specified entities like liposarcomas or angiosarcomas. A 18-year-old female presented in 2010 with a right breast lump for which lumpectomy was done and on histopathological examination benign phyllodes tumor was diagnosed. In 2011, there was a recurrence at site of excised margin and on fine needle aspiration (FNA) the diagnosis of benign breast disease was made; a small biopsy was received for which diagnosis of myoepithelial lesion was given. Then, the whole mass was excised, but histopathological examination report could not be followed up. In 2013, she again presented with a mass arising from the previously excised margin; on FNA, it was diagnosed as malignant sarcomatous lesion. Microscopy showed spindle shaped cells in diffuse and fascicular pattern with plump ovoid nuclei; coarse chromatin and eosinophilic cytoplasm were seen. Few round to ovoid cells with eccentric nuclei and showing bi- or multi-nucleation were present. Large area of necrosis and hemorrhage was present, too. No breast glands were found. Later on, diagnosis was confirmed on immunohistochemical examination. The case was considered worth due to the young age of the patient and lack of differentiation of the lesion in any specific type of sarcoma and CD10 positivity.

No MeSH data available.


Related in: MedlinePlus