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Large Malignant Phyllodes Tumor of the Breast with Metastases to the Lungs.

Augustyn A, Sahoo S, Wooldridge RD - Rare Tumors (2015)

Bottom Line: Phyllodes tumors of the breast account for less than 0.5% of breast cancers and present most commonly in women 45 to 49 years old.We report the case of a 56-year-old female who presented with a rapidly enlarging mass in her right breast 18 cm in maximum dimension that completely effaced the breast and distorted the nipple.The patient underwent a successful total mastectomy after core biopsy revealed a diagnosis of phyllodes tumor.

View Article: PubMed Central - PubMed

Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center , Dallas, TX, USA ; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center , Dallas, TX, USA.

ABSTRACT
Phyllodes tumors of the breast account for less than 0.5% of breast cancers and present most commonly in women 45 to 49 years old. The importance in managing fibroepithelial lesions lies in distinguishing fibroadenomas, which are benign, from phyllodes tumors, which can be malignant and require complete surgical excision. We report the case of a 56-year-old female who presented with a rapidly enlarging mass in her right breast 18 cm in maximum dimension that completely effaced the breast and distorted the nipple. The patient underwent a successful total mastectomy after core biopsy revealed a diagnosis of phyllodes tumor. Surgical resection is the primary treatment modality; neoadjuvant and adjuvant therapies remain controversial. Here, we report the case of a large malignant phyllodes tumor metastatic to the lungs, review the literature, and discuss diagnostic modalities and adjunct nonsurgical therapies.

No MeSH data available.


Related in: MedlinePlus

Phyllodes tumor metastases to the lung. A) Chest computed tomography (CT) showing multiple pulmonary nodules. B,C) CT-guided biopsy specimen (Hematoxylin and Eosin) of a lung nodule showing metastatic spindle cell tumor morphologically identical to the malignant phyllodes tumor.
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fig003: Phyllodes tumor metastases to the lung. A) Chest computed tomography (CT) showing multiple pulmonary nodules. B,C) CT-guided biopsy specimen (Hematoxylin and Eosin) of a lung nodule showing metastatic spindle cell tumor morphologically identical to the malignant phyllodes tumor.

Mentions: The patient underwent adjuvant radiotherapy. She remained progression-free until an interval chest X-ray and subsequent chest CT performed one year after surgical resection identified multiple pulmonary nodules that were consistent with metastatic disease (Figure 3A). She had no evidence of chest wall or skin recurrence. Five lesions were detected in the right lung and six in the left. A CT-guided core needle biopsy of a lung nodule identified metastatic phyllodes tumor (Figure 3B,C). At the time of this report, the patient declined chemotherapeutic intervention and is receiving palliative treatment.


Large Malignant Phyllodes Tumor of the Breast with Metastases to the Lungs.

Augustyn A, Sahoo S, Wooldridge RD - Rare Tumors (2015)

Phyllodes tumor metastases to the lung. A) Chest computed tomography (CT) showing multiple pulmonary nodules. B,C) CT-guided biopsy specimen (Hematoxylin and Eosin) of a lung nodule showing metastatic spindle cell tumor morphologically identical to the malignant phyllodes tumor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508638&req=5

fig003: Phyllodes tumor metastases to the lung. A) Chest computed tomography (CT) showing multiple pulmonary nodules. B,C) CT-guided biopsy specimen (Hematoxylin and Eosin) of a lung nodule showing metastatic spindle cell tumor morphologically identical to the malignant phyllodes tumor.
Mentions: The patient underwent adjuvant radiotherapy. She remained progression-free until an interval chest X-ray and subsequent chest CT performed one year after surgical resection identified multiple pulmonary nodules that were consistent with metastatic disease (Figure 3A). She had no evidence of chest wall or skin recurrence. Five lesions were detected in the right lung and six in the left. A CT-guided core needle biopsy of a lung nodule identified metastatic phyllodes tumor (Figure 3B,C). At the time of this report, the patient declined chemotherapeutic intervention and is receiving palliative treatment.

Bottom Line: Phyllodes tumors of the breast account for less than 0.5% of breast cancers and present most commonly in women 45 to 49 years old.We report the case of a 56-year-old female who presented with a rapidly enlarging mass in her right breast 18 cm in maximum dimension that completely effaced the breast and distorted the nipple.The patient underwent a successful total mastectomy after core biopsy revealed a diagnosis of phyllodes tumor.

View Article: PubMed Central - PubMed

Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center , Dallas, TX, USA ; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center , Dallas, TX, USA.

ABSTRACT
Phyllodes tumors of the breast account for less than 0.5% of breast cancers and present most commonly in women 45 to 49 years old. The importance in managing fibroepithelial lesions lies in distinguishing fibroadenomas, which are benign, from phyllodes tumors, which can be malignant and require complete surgical excision. We report the case of a 56-year-old female who presented with a rapidly enlarging mass in her right breast 18 cm in maximum dimension that completely effaced the breast and distorted the nipple. The patient underwent a successful total mastectomy after core biopsy revealed a diagnosis of phyllodes tumor. Surgical resection is the primary treatment modality; neoadjuvant and adjuvant therapies remain controversial. Here, we report the case of a large malignant phyllodes tumor metastatic to the lungs, review the literature, and discuss diagnostic modalities and adjunct nonsurgical therapies.

No MeSH data available.


Related in: MedlinePlus