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Large Malignant Phyllodes Tumor of the Breast with Metastases to the Lungs.

Augustyn A, Sahoo S, Wooldridge RD - Rare Tumors (2015)

Bottom Line: Phyllodes tumors of the breast account for less than 0.5% of breast cancers and present most commonly in women 45 to 49 years old.We report the case of a 56-year-old female who presented with a rapidly enlarging mass in her right breast 18 cm in maximum dimension that completely effaced the breast and distorted the nipple.The patient underwent a successful total mastectomy after core biopsy revealed a diagnosis of phyllodes tumor.

View Article: PubMed Central - PubMed

Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center , Dallas, TX, USA ; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center , Dallas, TX, USA.

ABSTRACT
Phyllodes tumors of the breast account for less than 0.5% of breast cancers and present most commonly in women 45 to 49 years old. The importance in managing fibroepithelial lesions lies in distinguishing fibroadenomas, which are benign, from phyllodes tumors, which can be malignant and require complete surgical excision. We report the case of a 56-year-old female who presented with a rapidly enlarging mass in her right breast 18 cm in maximum dimension that completely effaced the breast and distorted the nipple. The patient underwent a successful total mastectomy after core biopsy revealed a diagnosis of phyllodes tumor. Surgical resection is the primary treatment modality; neoadjuvant and adjuvant therapies remain controversial. Here, we report the case of a large malignant phyllodes tumor metastatic to the lungs, review the literature, and discuss diagnostic modalities and adjunct nonsurgical therapies.

No MeSH data available.


Related in: MedlinePlus

Pre-surgical photograph of the large phyllodes tumor effacing the right breast and demonstrating skin stretching, vein expansion, and near-total necrosis of the nippleareolar complex.
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fig001: Pre-surgical photograph of the large phyllodes tumor effacing the right breast and demonstrating skin stretching, vein expansion, and near-total necrosis of the nippleareolar complex.

Mentions: On physical examination, our patient was a well-developed, well-nourished female with an obvious right breast mass. At the time of presentation the mass measured 18 cm in greatest dimension. The skin was bright blue, although still viable, and was stretched over the mass such that it was difficult to distinguish the nipple from other areas of skin. At the time of surgery, her nipple-areolar complex became grossly necrotic (Figure 1). No axillary, mediastinal, or clavicular lymphadenopathy was appreciated and the contralateral breast was grossly normal.


Large Malignant Phyllodes Tumor of the Breast with Metastases to the Lungs.

Augustyn A, Sahoo S, Wooldridge RD - Rare Tumors (2015)

Pre-surgical photograph of the large phyllodes tumor effacing the right breast and demonstrating skin stretching, vein expansion, and near-total necrosis of the nippleareolar complex.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508638&req=5

fig001: Pre-surgical photograph of the large phyllodes tumor effacing the right breast and demonstrating skin stretching, vein expansion, and near-total necrosis of the nippleareolar complex.
Mentions: On physical examination, our patient was a well-developed, well-nourished female with an obvious right breast mass. At the time of presentation the mass measured 18 cm in greatest dimension. The skin was bright blue, although still viable, and was stretched over the mass such that it was difficult to distinguish the nipple from other areas of skin. At the time of surgery, her nipple-areolar complex became grossly necrotic (Figure 1). No axillary, mediastinal, or clavicular lymphadenopathy was appreciated and the contralateral breast was grossly normal.

Bottom Line: Phyllodes tumors of the breast account for less than 0.5% of breast cancers and present most commonly in women 45 to 49 years old.We report the case of a 56-year-old female who presented with a rapidly enlarging mass in her right breast 18 cm in maximum dimension that completely effaced the breast and distorted the nipple.The patient underwent a successful total mastectomy after core biopsy revealed a diagnosis of phyllodes tumor.

View Article: PubMed Central - PubMed

Affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center , Dallas, TX, USA ; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center , Dallas, TX, USA.

ABSTRACT
Phyllodes tumors of the breast account for less than 0.5% of breast cancers and present most commonly in women 45 to 49 years old. The importance in managing fibroepithelial lesions lies in distinguishing fibroadenomas, which are benign, from phyllodes tumors, which can be malignant and require complete surgical excision. We report the case of a 56-year-old female who presented with a rapidly enlarging mass in her right breast 18 cm in maximum dimension that completely effaced the breast and distorted the nipple. The patient underwent a successful total mastectomy after core biopsy revealed a diagnosis of phyllodes tumor. Surgical resection is the primary treatment modality; neoadjuvant and adjuvant therapies remain controversial. Here, we report the case of a large malignant phyllodes tumor metastatic to the lungs, review the literature, and discuss diagnostic modalities and adjunct nonsurgical therapies.

No MeSH data available.


Related in: MedlinePlus