Limits...
The Effects of Phosphatidylserine and Omega-3 Fatty Acid-Containing Supplement on Late Life Depression.

Komori T - Ment Illn (2015)

Bottom Line: The mean HAM-D17 in all subjects taking the supplement was significantly improved after 12 weeks of taking the supplement.The basal levels and circadian rhythm of salivary cortisol were normalized in the responders while not in non-responders.PS and omega-3 fatty acids, or other elements of the supplement, may be effective for late life depression, associated with the correction of basal levels and circadian rhythm of salivary cortisol.

View Article: PubMed Central - PubMed

Affiliation: Department of Adult Health and Psychiatric Nursing, Faculty of Medicine, School of Nursing, Mie University , Japan.

ABSTRACT
Late life depression is often associated with a poor response to antidepressants; therefore an alternative strategy for therapy is required. Although several studies have reported that phosphatidylserine (PS) may be effective for late life depression and that omega-3 fatty acids DHA and EPA have also proven beneficial for many higher mental functions, including depression, no concrete conclusion has been reached. This study was performed to clarify the effect of PS and omega-3 fatty acid-containing supplement for late life depression by not only clinical evaluation but also salivary cortisol levels. Eighteen elderly subjects with major depression were selected for the study. In all, insufficient improvement had been obtained by antidepressant therapy for at least 6 months. The exclusion criteria from prior brain magnetic resonance images (MRI) included the presence of structural MRI findings compatible with stroke or other gross brain lesions or malformations, but not white matter hypersensitivities. They took a supplement containing PS 100 mg, DHA 119 mg and EPA 70 mg three times a day for 12 weeks. The effects of the supplement were assessed using the 17-item Hamilton depression scale (HAM-D17) and the basal levels and circadian rhythm of salivary cortisol. The study adopted them as indices because: salivary cortisol levels are high in patients with depression, their circadian rhythm related to salivary cortisol is often irregular, and these symptoms are alleviated as depression improves. The mean HAM-D17 in all subjects taking the supplement was significantly improved after 12 weeks of taking the supplement. These subjects were divided into 10 non-responders and 8 responders. The basal levels and circadian rhythm of salivary cortisol were normalized in the responders while not in non-responders. PS and omega-3 fatty acids, or other elements of the supplement, may be effective for late life depression, associated with the correction of basal levels and circadian rhythm of salivary cortisol.

No MeSH data available.


Related in: MedlinePlus

Circadian rhythm of salivary cortisol at the beginning of PS administration (A) and after administration for 3 months (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4508628&req=5

fig002: Circadian rhythm of salivary cortisol at the beginning of PS administration (A) and after administration for 3 months (B).

Mentions: As shown in Figure 1B, at the start, cortisol levels in saliva were significantly (P=0.03) high compared with normal controls. There was no significant difference in the salivary cortisol level between the responders and non-responders at the start of supplement administration. In non-responders the levels of salivary cortisol continued to be significantly (P<0.05) high except 8 weeks after supplement administration, while in responders the levels of salivary cortisol were normalized after supplement administration. As shown in Figure 2A, in the results of measurements immediately, one hour, two hours, 3 hours and 4 hours after waking up in the morning, the peak value was not seen at waking up in 6 of 8 subjects before the responders began to use the supplement, but 12 weeks later the peak value was seen immediately after waking up in all subjects. In the control group, the peak was seen in 12 of 15 immediately after waking up. The difference between responders at the start and the control group was clear although it was not possible to compare using the chi-square test because there were only 2 subjects in whom the peak was seen immediately after waking up. The results after 12 weeks were not significantly (P=0.01) different from the control group. On the other hand, as shown in Figure 2B, in most of the non-responders the peak value was not seen immediately after waking up, not only before but also after supplement administration. The difference from the control group is clear although the chi-square test could not be performed.


The Effects of Phosphatidylserine and Omega-3 Fatty Acid-Containing Supplement on Late Life Depression.

Komori T - Ment Illn (2015)

Circadian rhythm of salivary cortisol at the beginning of PS administration (A) and after administration for 3 months (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508628&req=5

fig002: Circadian rhythm of salivary cortisol at the beginning of PS administration (A) and after administration for 3 months (B).
Mentions: As shown in Figure 1B, at the start, cortisol levels in saliva were significantly (P=0.03) high compared with normal controls. There was no significant difference in the salivary cortisol level between the responders and non-responders at the start of supplement administration. In non-responders the levels of salivary cortisol continued to be significantly (P<0.05) high except 8 weeks after supplement administration, while in responders the levels of salivary cortisol were normalized after supplement administration. As shown in Figure 2A, in the results of measurements immediately, one hour, two hours, 3 hours and 4 hours after waking up in the morning, the peak value was not seen at waking up in 6 of 8 subjects before the responders began to use the supplement, but 12 weeks later the peak value was seen immediately after waking up in all subjects. In the control group, the peak was seen in 12 of 15 immediately after waking up. The difference between responders at the start and the control group was clear although it was not possible to compare using the chi-square test because there were only 2 subjects in whom the peak was seen immediately after waking up. The results after 12 weeks were not significantly (P=0.01) different from the control group. On the other hand, as shown in Figure 2B, in most of the non-responders the peak value was not seen immediately after waking up, not only before but also after supplement administration. The difference from the control group is clear although the chi-square test could not be performed.

Bottom Line: The mean HAM-D17 in all subjects taking the supplement was significantly improved after 12 weeks of taking the supplement.The basal levels and circadian rhythm of salivary cortisol were normalized in the responders while not in non-responders.PS and omega-3 fatty acids, or other elements of the supplement, may be effective for late life depression, associated with the correction of basal levels and circadian rhythm of salivary cortisol.

View Article: PubMed Central - PubMed

Affiliation: Department of Adult Health and Psychiatric Nursing, Faculty of Medicine, School of Nursing, Mie University , Japan.

ABSTRACT
Late life depression is often associated with a poor response to antidepressants; therefore an alternative strategy for therapy is required. Although several studies have reported that phosphatidylserine (PS) may be effective for late life depression and that omega-3 fatty acids DHA and EPA have also proven beneficial for many higher mental functions, including depression, no concrete conclusion has been reached. This study was performed to clarify the effect of PS and omega-3 fatty acid-containing supplement for late life depression by not only clinical evaluation but also salivary cortisol levels. Eighteen elderly subjects with major depression were selected for the study. In all, insufficient improvement had been obtained by antidepressant therapy for at least 6 months. The exclusion criteria from prior brain magnetic resonance images (MRI) included the presence of structural MRI findings compatible with stroke or other gross brain lesions or malformations, but not white matter hypersensitivities. They took a supplement containing PS 100 mg, DHA 119 mg and EPA 70 mg three times a day for 12 weeks. The effects of the supplement were assessed using the 17-item Hamilton depression scale (HAM-D17) and the basal levels and circadian rhythm of salivary cortisol. The study adopted them as indices because: salivary cortisol levels are high in patients with depression, their circadian rhythm related to salivary cortisol is often irregular, and these symptoms are alleviated as depression improves. The mean HAM-D17 in all subjects taking the supplement was significantly improved after 12 weeks of taking the supplement. These subjects were divided into 10 non-responders and 8 responders. The basal levels and circadian rhythm of salivary cortisol were normalized in the responders while not in non-responders. PS and omega-3 fatty acids, or other elements of the supplement, may be effective for late life depression, associated with the correction of basal levels and circadian rhythm of salivary cortisol.

No MeSH data available.


Related in: MedlinePlus