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Acute Disseminated Encephalomyelitis After Plasmodium Vivax Infection: Case Report and Review of Literature.

Sidhu J, Maheshwari A, Gupta R, Devgan V - Pediatr Rep (2015)

Bottom Line: Its occurrence after Plasmodium vivax infection is extremely uncommon.Diagnosis of ADEM was made on the basis of magnetic resonance imaging findings.The child responded to corticosteroids with complete neurological recovery.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, North Delhi Municipal Corporation Medical College, Hindu Rao Hospital , New Delhi, India.

ABSTRACT
Acute demyelinating encephalomyelitis (ADEM) usually occurs after viral infections or vaccination. Its occurrence after Plasmodium vivax infection is extremely uncommon. We report the case of an 8-year-old girl who had choreo-athetoid movements and ataxia after recovery from P.vivax infection. Diagnosis of ADEM was made on the basis of magnetic resonance imaging findings. The child responded to corticosteroids with complete neurological recovery.

No MeSH data available.


Related in: MedlinePlus

Magnetic resonance imaging of the brain showing high-intensity signals in subcortical, cortical, left parietal, periventricular regions and pons.
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fig001: Magnetic resonance imaging of the brain showing high-intensity signals in subcortical, cortical, left parietal, periventricular regions and pons.

Mentions: The child responded well and was shifted to pediatric ward after one week of admission. Patient did not have any neurological deficit and repeat peripheral smears showed parasitological clearance. On day 15 of illness, the child presented with abnormal movements in form of ataxia and choreo-athetoid movements of limbs. There were no meningeal signs or cranial nerve palsies. Deep tendon reflexes were exaggerated and Babinski sign was present. Repeat peripheral blood smear examination did not show any malarial parasite. Magnetic resonance imaging (MRI) of brain with contrast showed high intensity signals in subcortical, cortical, left parietal, periventricular regions and pons (Figure 1). In view of temporal relationship and latency of symptoms and MRI findings, diagnosis of post malaria ADEM (secondary to P.vivax) was made. Patient was started on prednisolone at 2 mg/kg/day for 7 days and tapered over one week. Choreoathetoid movements decreased and ataxia improved. After 2 weeks of discharge, patient had no neurological sequelae.


Acute Disseminated Encephalomyelitis After Plasmodium Vivax Infection: Case Report and Review of Literature.

Sidhu J, Maheshwari A, Gupta R, Devgan V - Pediatr Rep (2015)

Magnetic resonance imaging of the brain showing high-intensity signals in subcortical, cortical, left parietal, periventricular regions and pons.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508623&req=5

fig001: Magnetic resonance imaging of the brain showing high-intensity signals in subcortical, cortical, left parietal, periventricular regions and pons.
Mentions: The child responded well and was shifted to pediatric ward after one week of admission. Patient did not have any neurological deficit and repeat peripheral smears showed parasitological clearance. On day 15 of illness, the child presented with abnormal movements in form of ataxia and choreo-athetoid movements of limbs. There were no meningeal signs or cranial nerve palsies. Deep tendon reflexes were exaggerated and Babinski sign was present. Repeat peripheral blood smear examination did not show any malarial parasite. Magnetic resonance imaging (MRI) of brain with contrast showed high intensity signals in subcortical, cortical, left parietal, periventricular regions and pons (Figure 1). In view of temporal relationship and latency of symptoms and MRI findings, diagnosis of post malaria ADEM (secondary to P.vivax) was made. Patient was started on prednisolone at 2 mg/kg/day for 7 days and tapered over one week. Choreoathetoid movements decreased and ataxia improved. After 2 weeks of discharge, patient had no neurological sequelae.

Bottom Line: Its occurrence after Plasmodium vivax infection is extremely uncommon.Diagnosis of ADEM was made on the basis of magnetic resonance imaging findings.The child responded to corticosteroids with complete neurological recovery.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, North Delhi Municipal Corporation Medical College, Hindu Rao Hospital , New Delhi, India.

ABSTRACT
Acute demyelinating encephalomyelitis (ADEM) usually occurs after viral infections or vaccination. Its occurrence after Plasmodium vivax infection is extremely uncommon. We report the case of an 8-year-old girl who had choreo-athetoid movements and ataxia after recovery from P.vivax infection. Diagnosis of ADEM was made on the basis of magnetic resonance imaging findings. The child responded to corticosteroids with complete neurological recovery.

No MeSH data available.


Related in: MedlinePlus