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Dosimetric Comparison and Evaluation of Three Radiotherapy Techniques for Use after Modified Radical Mastectomy for Locally Advanced Left-sided Breast Cancer.

Ma C, Zhang W, Lu J, Wu L, Wu F, Huang B, Lin Y, Li D - Sci Rep (2015)

Bottom Line: P < 0.05 was considered statistically significant.Both 5F-IMRT and 2P-VMAT plans exhibited similar PTV coverage (V95%), hotspot areas (V110%) and conformity (all p > 0.05), and significantly higher PTV coverage compared with 3DCRT-FinF (both p < 0.001).Individually quantifying and minimizing CTV displacement can significantly improve dosage distribution.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, 515031, Guangdong Province, China.

ABSTRACT
This study aimed to compare the post-modified radical mastectomy radiotherapy (PMRMRT) for left-sided breast cancer utilizing 3-dimensional conformal radiotherapy with field-in-field technique (3DCRT-FinF), 5-field intensity-modulated radiation therapy (5F-IMRT) and 2- partial arc volumetric modulated arc therapy (2P-VMAT). We created the 3 different PMRMRT plans for each of the ten consecutive patients. We performed Kruskal-Wallis analysis of variance (ANOVA) followed by the Dunn's-type multiple comparisons to establish a hierarchy in terms of plan quality and dosimetric benefits. P < 0.05 was considered statistically significant. Both 5F-IMRT and 2P-VMAT plans exhibited similar PTV coverage (V95%), hotspot areas (V110%) and conformity (all p > 0.05), and significantly higher PTV coverage compared with 3DCRT-FinF (both p < 0.001). In addition, 5F-IMRT plans provided significantly less heart and left lung radiation exposure than 2P-VMAT (all p < 0.05). The 3DCRT-FinF plans with accurately estimated CTV displacement exhibited enhanced target coverage but worse organs at risk (OARs) sparing compared with those plans with underestimated displacements. Our results indicate that 5F-IMRT has dosimetrical advantages compared with the other two techniques in PMRMRT for left-sided breast cancer given its optimal balance between PTV coverage and OAR sparing (especially heart sparing). Individually quantifying and minimizing CTV displacement can significantly improve dosage distribution.

No MeSH data available.


Related in: MedlinePlus

Comparison of DVHs between 3DCRT-FinF plans with a PTV of 0.5 cm and a PTV of 0.7cm.The two sets of 3DCRT-FinF plans for each patient were created based on CTV displacement estimations of 0.7 cm and 0.5 cm, respectively. The comparison was performed presuming that the “actual” displacement of the CTVs was 0.7 cm isotropically.
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f3: Comparison of DVHs between 3DCRT-FinF plans with a PTV of 0.5 cm and a PTV of 0.7cm.The two sets of 3DCRT-FinF plans for each patient were created based on CTV displacement estimations of 0.7 cm and 0.5 cm, respectively. The comparison was performed presuming that the “actual” displacement of the CTVs was 0.7 cm isotropically.

Mentions: The 3DCRT-FinF-PTV 0.7 cm plans based on accurately estimated CTV displacement values of 0.7 cm exhibited better PTV coverage but worse OAR (heart, left lung) sparing compared with the 3DCRT-FinF-PTV 0.5 cm plans based on underestimation of CTV displacement values of 0.5 cm, assuming that the “actual” displacement of CTV was 0.7 cm isotropically (Fig. 3 and Table 3).


Dosimetric Comparison and Evaluation of Three Radiotherapy Techniques for Use after Modified Radical Mastectomy for Locally Advanced Left-sided Breast Cancer.

Ma C, Zhang W, Lu J, Wu L, Wu F, Huang B, Lin Y, Li D - Sci Rep (2015)

Comparison of DVHs between 3DCRT-FinF plans with a PTV of 0.5 cm and a PTV of 0.7cm.The two sets of 3DCRT-FinF plans for each patient were created based on CTV displacement estimations of 0.7 cm and 0.5 cm, respectively. The comparison was performed presuming that the “actual” displacement of the CTVs was 0.7 cm isotropically.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508617&req=5

f3: Comparison of DVHs between 3DCRT-FinF plans with a PTV of 0.5 cm and a PTV of 0.7cm.The two sets of 3DCRT-FinF plans for each patient were created based on CTV displacement estimations of 0.7 cm and 0.5 cm, respectively. The comparison was performed presuming that the “actual” displacement of the CTVs was 0.7 cm isotropically.
Mentions: The 3DCRT-FinF-PTV 0.7 cm plans based on accurately estimated CTV displacement values of 0.7 cm exhibited better PTV coverage but worse OAR (heart, left lung) sparing compared with the 3DCRT-FinF-PTV 0.5 cm plans based on underestimation of CTV displacement values of 0.5 cm, assuming that the “actual” displacement of CTV was 0.7 cm isotropically (Fig. 3 and Table 3).

Bottom Line: P < 0.05 was considered statistically significant.Both 5F-IMRT and 2P-VMAT plans exhibited similar PTV coverage (V95%), hotspot areas (V110%) and conformity (all p > 0.05), and significantly higher PTV coverage compared with 3DCRT-FinF (both p < 0.001).Individually quantifying and minimizing CTV displacement can significantly improve dosage distribution.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, 515031, Guangdong Province, China.

ABSTRACT
This study aimed to compare the post-modified radical mastectomy radiotherapy (PMRMRT) for left-sided breast cancer utilizing 3-dimensional conformal radiotherapy with field-in-field technique (3DCRT-FinF), 5-field intensity-modulated radiation therapy (5F-IMRT) and 2- partial arc volumetric modulated arc therapy (2P-VMAT). We created the 3 different PMRMRT plans for each of the ten consecutive patients. We performed Kruskal-Wallis analysis of variance (ANOVA) followed by the Dunn's-type multiple comparisons to establish a hierarchy in terms of plan quality and dosimetric benefits. P < 0.05 was considered statistically significant. Both 5F-IMRT and 2P-VMAT plans exhibited similar PTV coverage (V95%), hotspot areas (V110%) and conformity (all p > 0.05), and significantly higher PTV coverage compared with 3DCRT-FinF (both p < 0.001). In addition, 5F-IMRT plans provided significantly less heart and left lung radiation exposure than 2P-VMAT (all p < 0.05). The 3DCRT-FinF plans with accurately estimated CTV displacement exhibited enhanced target coverage but worse organs at risk (OARs) sparing compared with those plans with underestimated displacements. Our results indicate that 5F-IMRT has dosimetrical advantages compared with the other two techniques in PMRMRT for left-sided breast cancer given its optimal balance between PTV coverage and OAR sparing (especially heart sparing). Individually quantifying and minimizing CTV displacement can significantly improve dosage distribution.

No MeSH data available.


Related in: MedlinePlus