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The Relationship Between Left Ventricular Fractional Shortening and Intravenous Administration of Stem Cells in Laboratory Rabbits Presenting Chronic Myocardial Infarction.

Pop IC, Grad O, Pall E, Pestean C, Mircean M, Mironiuc IA - Clujul Med (2015)

Bottom Line: An improvement of LV SF 30 days after MSCs were injected(p<0.0001) was noted.We have to further determine if this improvement of the LV function is correlated with any histopathological changes and if it is not lost in time.Also, further studies needs to evaluate if there is any significant change in the overall mortality.

View Article: PubMed Central - PubMed

Affiliation: 2-nd Surgical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

ABSTRACT

Background and aims: The present study conducted from March 2012 to July 2013 aimed to evaluate from echocardiographic point of view the effects of peripheral intravenous administration of mesenchymal stem cells (MSCs) in laboratory rabbits presenting 30 days old chronic myocardial infarction.

Material and methods: 30 days after the induction of an acute myocardial infarction in 40 laboratory rabbits by direct ligation of the left anterior descending coronary artery at about 10 mm from the apex, we injected 1×106 MSCs in the auricular vein in a group of 30 rabbits, and a group of 10 rabbits were used as controls. 30 days after the injection of stem cells the left ventricular (LV) fractional shortening (FS) was evaluated by echocardiography and compared with the control rabbits.

Results: In control rabbits, echocardiography revealed akinesis of apex, interventricular septum kinetics was also impaired, FS being approximately 6%. In 80% (24 rabbits) of the injected rabbits the FS of the LV was significantly greater than in the witness group (26+/-2%, p<0.0001). At 13.3% (4 rabbits) of the injected rabbits the FS of the LV showed no improvement in comparison with the control group (6.5+/-1%).

Conclusion: An improvement of LV SF 30 days after MSCs were injected(p<0.0001) was noted. We have to further determine if this improvement of the LV function is correlated with any histopathological changes and if it is not lost in time. Also, further studies needs to evaluate if there is any significant change in the overall mortality.

No MeSH data available.


Related in: MedlinePlus

Echocardiography in a control rabbit showing akinesia of the apex.
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f1-cm8801p28: Echocardiography in a control rabbit showing akinesia of the apex.

Mentions: In control rabbits, echocardiography performed 60 days after the induction of the acute myocardial infarction evidenced a severe impaired LV function, the FS being approx. 6%, akinesia of LV apex was also noted and interventricular septum kinetics was also impaired (Fig. 1).


The Relationship Between Left Ventricular Fractional Shortening and Intravenous Administration of Stem Cells in Laboratory Rabbits Presenting Chronic Myocardial Infarction.

Pop IC, Grad O, Pall E, Pestean C, Mircean M, Mironiuc IA - Clujul Med (2015)

Echocardiography in a control rabbit showing akinesia of the apex.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508605&req=5

f1-cm8801p28: Echocardiography in a control rabbit showing akinesia of the apex.
Mentions: In control rabbits, echocardiography performed 60 days after the induction of the acute myocardial infarction evidenced a severe impaired LV function, the FS being approx. 6%, akinesia of LV apex was also noted and interventricular septum kinetics was also impaired (Fig. 1).

Bottom Line: An improvement of LV SF 30 days after MSCs were injected(p<0.0001) was noted.We have to further determine if this improvement of the LV function is correlated with any histopathological changes and if it is not lost in time.Also, further studies needs to evaluate if there is any significant change in the overall mortality.

View Article: PubMed Central - PubMed

Affiliation: 2-nd Surgical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

ABSTRACT

Background and aims: The present study conducted from March 2012 to July 2013 aimed to evaluate from echocardiographic point of view the effects of peripheral intravenous administration of mesenchymal stem cells (MSCs) in laboratory rabbits presenting 30 days old chronic myocardial infarction.

Material and methods: 30 days after the induction of an acute myocardial infarction in 40 laboratory rabbits by direct ligation of the left anterior descending coronary artery at about 10 mm from the apex, we injected 1×106 MSCs in the auricular vein in a group of 30 rabbits, and a group of 10 rabbits were used as controls. 30 days after the injection of stem cells the left ventricular (LV) fractional shortening (FS) was evaluated by echocardiography and compared with the control rabbits.

Results: In control rabbits, echocardiography revealed akinesis of apex, interventricular septum kinetics was also impaired, FS being approximately 6%. In 80% (24 rabbits) of the injected rabbits the FS of the LV was significantly greater than in the witness group (26+/-2%, p<0.0001). At 13.3% (4 rabbits) of the injected rabbits the FS of the LV showed no improvement in comparison with the control group (6.5+/-1%).

Conclusion: An improvement of LV SF 30 days after MSCs were injected(p<0.0001) was noted. We have to further determine if this improvement of the LV function is correlated with any histopathological changes and if it is not lost in time. Also, further studies needs to evaluate if there is any significant change in the overall mortality.

No MeSH data available.


Related in: MedlinePlus