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Castleman Disease. A Report of Six Cases.

Fetica B, Pop B, Lisencu C, Rancea AC, Coman A, Cucuianu A, Petrov L - Clujul Med (2014)

Bottom Line: The clinical symptoms were related mostly to compression effects.One case showed angiomyoid differentiation.We strongly believe that by understanding the pathogenesis of the precursor lesions we will gain better understanding of the pathways that lead to neoplasia and that Castleman disesase is a very interesting "natural experiment" illustrating the progression from chronic antigen stimulation to reactive lymphoid hyperplasia and finally to overt lymphoid neoplasia.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, "Prof. Dr. I. Chiricuta" Oncology Institute, Cluj-Napoca, Romania.

ABSTRACT

Background and aims: Castleman's disease is a rare disorder situated at the boundary between reactive and neoplastic conditions. The pathogenesis is a subject of debate and the limited number of cases renders the study of the disease difficult. In our paper we present a series of six cases of Castleman disease with emphasis on the clinical presentation, pathology examination and the use of immunohistochemistry in the final diagnosis of the cases.

Patients and method: The classification of the disease was based on clinical, imaging and pathological assessment. Specimens were obtained by surgical excision and were routinely processed for the pathology examination.

Results: All cases were unicentric disease. Two cases were locally extensive. The clinical symptoms were related mostly to compression effects. Five case were of the hyaline-vascular type and one was included in the plasma cell variant. One case showed angiomyoid differentiation.

Conclusions: We strongly believe that by understanding the pathogenesis of the precursor lesions we will gain better understanding of the pathways that lead to neoplasia and that Castleman disesase is a very interesting "natural experiment" illustrating the progression from chronic antigen stimulation to reactive lymphoid hyperplasia and finally to overt lymphoid neoplasia.

No MeSH data available.


Related in: MedlinePlus

Schematic representation of the pathogenesis of the disease [4].
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f2-cm8703p192: Schematic representation of the pathogenesis of the disease [4].


Castleman Disease. A Report of Six Cases.

Fetica B, Pop B, Lisencu C, Rancea AC, Coman A, Cucuianu A, Petrov L - Clujul Med (2014)

Schematic representation of the pathogenesis of the disease [4].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508595&req=5

f2-cm8703p192: Schematic representation of the pathogenesis of the disease [4].
Bottom Line: The clinical symptoms were related mostly to compression effects.One case showed angiomyoid differentiation.We strongly believe that by understanding the pathogenesis of the precursor lesions we will gain better understanding of the pathways that lead to neoplasia and that Castleman disesase is a very interesting "natural experiment" illustrating the progression from chronic antigen stimulation to reactive lymphoid hyperplasia and finally to overt lymphoid neoplasia.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, "Prof. Dr. I. Chiricuta" Oncology Institute, Cluj-Napoca, Romania.

ABSTRACT

Background and aims: Castleman's disease is a rare disorder situated at the boundary between reactive and neoplastic conditions. The pathogenesis is a subject of debate and the limited number of cases renders the study of the disease difficult. In our paper we present a series of six cases of Castleman disease with emphasis on the clinical presentation, pathology examination and the use of immunohistochemistry in the final diagnosis of the cases.

Patients and method: The classification of the disease was based on clinical, imaging and pathological assessment. Specimens were obtained by surgical excision and were routinely processed for the pathology examination.

Results: All cases were unicentric disease. Two cases were locally extensive. The clinical symptoms were related mostly to compression effects. Five case were of the hyaline-vascular type and one was included in the plasma cell variant. One case showed angiomyoid differentiation.

Conclusions: We strongly believe that by understanding the pathogenesis of the precursor lesions we will gain better understanding of the pathways that lead to neoplasia and that Castleman disesase is a very interesting "natural experiment" illustrating the progression from chronic antigen stimulation to reactive lymphoid hyperplasia and finally to overt lymphoid neoplasia.

No MeSH data available.


Related in: MedlinePlus