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A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature.

Jung HY, Cho H, Chung JH, Bae SB, Lee JH, Lee HJ, Jang SH, Oh MH - J Pathol Transl Med (2015)

Bottom Line: Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features.Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor.A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

ABSTRACT
Thymic carcinomas are uncommon malignant tumors, and thymic adenocarcinomas are extremely rare. Here, we describe a case of primary thymic adenocarcinoma in a 59-year-old woman. Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features. Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor. A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.

No MeSH data available.


Related in: MedlinePlus

Pathologic examination. (A) Gross examination of the tumor reveals an ill-defined mass with pericardial invasion (arrows, pericardium). (B) Microscopically, the tumor is surrounded by normal thymic tissues. At higher magnification, the tumor is composed of glandular or tubular structures with large glands lined by tall columnar cells (C) and oval cells forming small glands (D). The tumor cells show positive staining for CK7 (E), CK20 (F), CDX2 (G), and CD5 (H). CK, cytokeratin; CDX2, caudal type homeobox 2.
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f2-jptm-49-4-331: Pathologic examination. (A) Gross examination of the tumor reveals an ill-defined mass with pericardial invasion (arrows, pericardium). (B) Microscopically, the tumor is surrounded by normal thymic tissues. At higher magnification, the tumor is composed of glandular or tubular structures with large glands lined by tall columnar cells (C) and oval cells forming small glands (D). The tumor cells show positive staining for CK7 (E), CK20 (F), CDX2 (G), and CD5 (H). CK, cytokeratin; CDX2, caudal type homeobox 2.

Mentions: Gross examination identified a solid mass measuring 6.8×4.7×3.9 cm. The tumor was unencapsulated and invaded the pericardium. The mass was firm and rubbery with a homogeneous gray-whitish cut surface. There was no internal fibrous septation (Fig. 2A). Microscopic examination revealed that the tumor was surrounded by normal thymic tissue and was composed of various-sized glandular structures (Fig. 2B). The tumor cells were columnar and oval, forming cystic, tubular, and cribriform structures containing necrotic material. Immunohistochemical staining showed focally positive CK7 staining and diffusely strong positive staining for CK20 and CDX2 (Fig. 2C–G) but negative staining for thyroid transcription factor 1 (TTF-1) and Napsin A. CD5 staining was positive for both tumor cells and T lymphocytes in the normal thymus parenchyma and stroma between tumor cell nests (Fig. 2H).


A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature.

Jung HY, Cho H, Chung JH, Bae SB, Lee JH, Lee HJ, Jang SH, Oh MH - J Pathol Transl Med (2015)

Pathologic examination. (A) Gross examination of the tumor reveals an ill-defined mass with pericardial invasion (arrows, pericardium). (B) Microscopically, the tumor is surrounded by normal thymic tissues. At higher magnification, the tumor is composed of glandular or tubular structures with large glands lined by tall columnar cells (C) and oval cells forming small glands (D). The tumor cells show positive staining for CK7 (E), CK20 (F), CDX2 (G), and CD5 (H). CK, cytokeratin; CDX2, caudal type homeobox 2.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508571&req=5

f2-jptm-49-4-331: Pathologic examination. (A) Gross examination of the tumor reveals an ill-defined mass with pericardial invasion (arrows, pericardium). (B) Microscopically, the tumor is surrounded by normal thymic tissues. At higher magnification, the tumor is composed of glandular or tubular structures with large glands lined by tall columnar cells (C) and oval cells forming small glands (D). The tumor cells show positive staining for CK7 (E), CK20 (F), CDX2 (G), and CD5 (H). CK, cytokeratin; CDX2, caudal type homeobox 2.
Mentions: Gross examination identified a solid mass measuring 6.8×4.7×3.9 cm. The tumor was unencapsulated and invaded the pericardium. The mass was firm and rubbery with a homogeneous gray-whitish cut surface. There was no internal fibrous septation (Fig. 2A). Microscopic examination revealed that the tumor was surrounded by normal thymic tissue and was composed of various-sized glandular structures (Fig. 2B). The tumor cells were columnar and oval, forming cystic, tubular, and cribriform structures containing necrotic material. Immunohistochemical staining showed focally positive CK7 staining and diffusely strong positive staining for CK20 and CDX2 (Fig. 2C–G) but negative staining for thyroid transcription factor 1 (TTF-1) and Napsin A. CD5 staining was positive for both tumor cells and T lymphocytes in the normal thymus parenchyma and stroma between tumor cell nests (Fig. 2H).

Bottom Line: Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features.Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor.A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

ABSTRACT
Thymic carcinomas are uncommon malignant tumors, and thymic adenocarcinomas are extremely rare. Here, we describe a case of primary thymic adenocarcinoma in a 59-year-old woman. Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features. Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor. A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.

No MeSH data available.


Related in: MedlinePlus