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A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature.

Jung HY, Cho H, Chung JH, Bae SB, Lee JH, Lee HJ, Jang SH, Oh MH - J Pathol Transl Med (2015)

Bottom Line: Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features.Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor.A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

ABSTRACT
Thymic carcinomas are uncommon malignant tumors, and thymic adenocarcinomas are extremely rare. Here, we describe a case of primary thymic adenocarcinoma in a 59-year-old woman. Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features. Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor. A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.

No MeSH data available.


Related in: MedlinePlus

Radiologic examination of the anterior mediastinum. (A) An irregularly enhancing mass (arrow) in the anterior mediastinum on a chest computed tomography scan. (B) Abnormal hyperuptake in lesions at the 10th vertebra (arrowhead) and the left 10th rib (arrow) on a wholebody positron emission tomography scan.
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f1-jptm-49-4-331: Radiologic examination of the anterior mediastinum. (A) An irregularly enhancing mass (arrow) in the anterior mediastinum on a chest computed tomography scan. (B) Abnormal hyperuptake in lesions at the 10th vertebra (arrowhead) and the left 10th rib (arrow) on a wholebody positron emission tomography scan.

Mentions: A previously healthy 59-year-old woman presented with abdominal pain in the lower left quadrant that had persisted for 3 months. Endoscopic studies failed to reveal specific changes in the whole gastrointestinal tract mucosa. Imaging studies revealed an anterior mediastinal mass (Fig. 1A) and multiple lung nodules. Additionally, a whole-body positron emission tomography scan showed abnormal hyperuptake lesions in the left 10th rib and 10th vertebral body, suggesting metastasis (Fig. 1B). Laboratory tests indicated elevated levels of several serum tumor markers (carbohydrate antigen [CA] 19-9, 252.2 U/mL; CA125, 62.9 IU/mL; and carcinoembryonic antigen, 8.73 ng/mL).


A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature.

Jung HY, Cho H, Chung JH, Bae SB, Lee JH, Lee HJ, Jang SH, Oh MH - J Pathol Transl Med (2015)

Radiologic examination of the anterior mediastinum. (A) An irregularly enhancing mass (arrow) in the anterior mediastinum on a chest computed tomography scan. (B) Abnormal hyperuptake in lesions at the 10th vertebra (arrowhead) and the left 10th rib (arrow) on a wholebody positron emission tomography scan.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508571&req=5

f1-jptm-49-4-331: Radiologic examination of the anterior mediastinum. (A) An irregularly enhancing mass (arrow) in the anterior mediastinum on a chest computed tomography scan. (B) Abnormal hyperuptake in lesions at the 10th vertebra (arrowhead) and the left 10th rib (arrow) on a wholebody positron emission tomography scan.
Mentions: A previously healthy 59-year-old woman presented with abdominal pain in the lower left quadrant that had persisted for 3 months. Endoscopic studies failed to reveal specific changes in the whole gastrointestinal tract mucosa. Imaging studies revealed an anterior mediastinal mass (Fig. 1A) and multiple lung nodules. Additionally, a whole-body positron emission tomography scan showed abnormal hyperuptake lesions in the left 10th rib and 10th vertebral body, suggesting metastasis (Fig. 1B). Laboratory tests indicated elevated levels of several serum tumor markers (carbohydrate antigen [CA] 19-9, 252.2 U/mL; CA125, 62.9 IU/mL; and carcinoembryonic antigen, 8.73 ng/mL).

Bottom Line: Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features.Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor.A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

ABSTRACT
Thymic carcinomas are uncommon malignant tumors, and thymic adenocarcinomas are extremely rare. Here, we describe a case of primary thymic adenocarcinoma in a 59-year-old woman. Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features. Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor. A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.

No MeSH data available.


Related in: MedlinePlus