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WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm.

Escalante Abril PA, Salazar MF, López García NL, Madrazo Moya MN, Zamora Guerra YU, Mata Mendoza YG, Gómez Apo E, Chávez Macías LG - J Pathol Transl Med (2015)

Bottom Line: Tumour sampling was performed but the patient ultimately died as a result of disease.With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal.As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.

View Article: PubMed Central - PubMed

Affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.

ABSTRACT
We report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neoplasm. Tumour sampling was performed but the patient ultimately died as a result of disease. Microscopically, the lesion had areas of glioblastoma mixed with a benign mesenchymal constituent; the former showed hypercellularity, endothelial proliferation, high mitotic activity and necrosis, while the latter showed fascicles of long spindle cells surrounded by collagen and reticulin fibers. With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.

No MeSH data available.


Related in: MedlinePlus

Histochemical stains of whole-mount sections. (A, B) Collagen-rich tissue seen with Masson’s trichrome. (C, D) Reticulin pattern showed with reticular fiber stain.
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f2-jptm-49-4-325: Histochemical stains of whole-mount sections. (A, B) Collagen-rich tissue seen with Masson’s trichrome. (C, D) Reticulin pattern showed with reticular fiber stain.

Mentions: Histologically, the lesion showed areas unequivocally consistent with glioblastoma due to their microvascular proliferation, palisading necrosis, hypercellularity, pleomorphism, and high mitotic activity (Fig. 1C, D). These areas intermingled with cytologically bland, long spindle-cell fascicles (Fig. 1E, F) enveloped by sturdy collagen and fine reticulin fibers (Fig. 2A–D). As expected, immunoperoxidase-coupled reactions showed strong and diffuse expression of glial fibrillary acidic protein in the glioblastoma areas (Fig. 3A), while the spindled part of the neoplasm was exclusively positive for vimentin (Fig. 3B). Ki-67 expression was variable, with positivity as high as 50% in the astroglial regions (Fig. 3C) but with immunolabeling of less than 1% in the mesenchymal portion. Likewise, expression of p53 was largely diffuse in the gliomatous parts, albeit focally in some fusiform cells (Fig. 3D, E). No reaction was detected for epidermal growth factor receptor in either element.


WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm.

Escalante Abril PA, Salazar MF, López García NL, Madrazo Moya MN, Zamora Guerra YU, Mata Mendoza YG, Gómez Apo E, Chávez Macías LG - J Pathol Transl Med (2015)

Histochemical stains of whole-mount sections. (A, B) Collagen-rich tissue seen with Masson’s trichrome. (C, D) Reticulin pattern showed with reticular fiber stain.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508570&req=5

f2-jptm-49-4-325: Histochemical stains of whole-mount sections. (A, B) Collagen-rich tissue seen with Masson’s trichrome. (C, D) Reticulin pattern showed with reticular fiber stain.
Mentions: Histologically, the lesion showed areas unequivocally consistent with glioblastoma due to their microvascular proliferation, palisading necrosis, hypercellularity, pleomorphism, and high mitotic activity (Fig. 1C, D). These areas intermingled with cytologically bland, long spindle-cell fascicles (Fig. 1E, F) enveloped by sturdy collagen and fine reticulin fibers (Fig. 2A–D). As expected, immunoperoxidase-coupled reactions showed strong and diffuse expression of glial fibrillary acidic protein in the glioblastoma areas (Fig. 3A), while the spindled part of the neoplasm was exclusively positive for vimentin (Fig. 3B). Ki-67 expression was variable, with positivity as high as 50% in the astroglial regions (Fig. 3C) but with immunolabeling of less than 1% in the mesenchymal portion. Likewise, expression of p53 was largely diffuse in the gliomatous parts, albeit focally in some fusiform cells (Fig. 3D, E). No reaction was detected for epidermal growth factor receptor in either element.

Bottom Line: Tumour sampling was performed but the patient ultimately died as a result of disease.With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal.As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.

View Article: PubMed Central - PubMed

Affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.

ABSTRACT
We report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neoplasm. Tumour sampling was performed but the patient ultimately died as a result of disease. Microscopically, the lesion had areas of glioblastoma mixed with a benign mesenchymal constituent; the former showed hypercellularity, endothelial proliferation, high mitotic activity and necrosis, while the latter showed fascicles of long spindle cells surrounded by collagen and reticulin fibers. With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.

No MeSH data available.


Related in: MedlinePlus