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WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm.

Escalante Abril PA, Salazar MF, López García NL, Madrazo Moya MN, Zamora Guerra YU, Mata Mendoza YG, Gómez Apo E, Chávez Macías LG - J Pathol Transl Med (2015)

Bottom Line: Tumour sampling was performed but the patient ultimately died as a result of disease.With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal.As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.

View Article: PubMed Central - PubMed

Affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.

ABSTRACT
We report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neoplasm. Tumour sampling was performed but the patient ultimately died as a result of disease. Microscopically, the lesion had areas of glioblastoma mixed with a benign mesenchymal constituent; the former showed hypercellularity, endothelial proliferation, high mitotic activity and necrosis, while the latter showed fascicles of long spindle cells surrounded by collagen and reticulin fibers. With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.

No MeSH data available.


Related in: MedlinePlus

Magnetic resonance imaging scans and biphasic histological features. (A) Post-contrast, T1-weighted sagittal section. A heterogeneous tumour with an enhancing peripheral rim is shown. (B) Fluid-attenuated inversion recovery sequence. Considerable outlying oedema can be seen. (C) Glioblastomatous component with palisading necrosis and microvascular proliferation (upper right inset). (D) Boundary zone with neoplastic cells of gemistocytic appearance (left) next to apparently atypical spindle cells (right). Mitoses are noticeable exclusively in neoplastic glial cells (arrow). (E) Mesenchymal component with solid fascicular tissue intermingled with loose astrocytic areas. (F) High-magnification photomicrograph of the cytologically bland mesenchymal constituent.
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f1-jptm-49-4-325: Magnetic resonance imaging scans and biphasic histological features. (A) Post-contrast, T1-weighted sagittal section. A heterogeneous tumour with an enhancing peripheral rim is shown. (B) Fluid-attenuated inversion recovery sequence. Considerable outlying oedema can be seen. (C) Glioblastomatous component with palisading necrosis and microvascular proliferation (upper right inset). (D) Boundary zone with neoplastic cells of gemistocytic appearance (left) next to apparently atypical spindle cells (right). Mitoses are noticeable exclusively in neoplastic glial cells (arrow). (E) Mesenchymal component with solid fascicular tissue intermingled with loose astrocytic areas. (F) High-magnification photomicrograph of the cytologically bland mesenchymal constituent.

Mentions: A 50-year-old female presented with headache and loss of memory over the previous six months. Magnetic resonance imaging scans showed a left parieto-temporal mass (70.82×48.56 ×43.97 mm) with significant perilesional oedema and post-contrast annular enhancement (Fig. 1A, B). Despite prompt tumour sampling and analysis, the patient ultimately expired one month after the surgery. Necropsy was not authorized.


WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm.

Escalante Abril PA, Salazar MF, López García NL, Madrazo Moya MN, Zamora Guerra YU, Mata Mendoza YG, Gómez Apo E, Chávez Macías LG - J Pathol Transl Med (2015)

Magnetic resonance imaging scans and biphasic histological features. (A) Post-contrast, T1-weighted sagittal section. A heterogeneous tumour with an enhancing peripheral rim is shown. (B) Fluid-attenuated inversion recovery sequence. Considerable outlying oedema can be seen. (C) Glioblastomatous component with palisading necrosis and microvascular proliferation (upper right inset). (D) Boundary zone with neoplastic cells of gemistocytic appearance (left) next to apparently atypical spindle cells (right). Mitoses are noticeable exclusively in neoplastic glial cells (arrow). (E) Mesenchymal component with solid fascicular tissue intermingled with loose astrocytic areas. (F) High-magnification photomicrograph of the cytologically bland mesenchymal constituent.
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Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4508570&req=5

f1-jptm-49-4-325: Magnetic resonance imaging scans and biphasic histological features. (A) Post-contrast, T1-weighted sagittal section. A heterogeneous tumour with an enhancing peripheral rim is shown. (B) Fluid-attenuated inversion recovery sequence. Considerable outlying oedema can be seen. (C) Glioblastomatous component with palisading necrosis and microvascular proliferation (upper right inset). (D) Boundary zone with neoplastic cells of gemistocytic appearance (left) next to apparently atypical spindle cells (right). Mitoses are noticeable exclusively in neoplastic glial cells (arrow). (E) Mesenchymal component with solid fascicular tissue intermingled with loose astrocytic areas. (F) High-magnification photomicrograph of the cytologically bland mesenchymal constituent.
Mentions: A 50-year-old female presented with headache and loss of memory over the previous six months. Magnetic resonance imaging scans showed a left parieto-temporal mass (70.82×48.56 ×43.97 mm) with significant perilesional oedema and post-contrast annular enhancement (Fig. 1A, B). Despite prompt tumour sampling and analysis, the patient ultimately expired one month after the surgery. Necropsy was not authorized.

Bottom Line: Tumour sampling was performed but the patient ultimately died as a result of disease.With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal.As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.

View Article: PubMed Central - PubMed

Affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.

ABSTRACT
We report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neoplasm. Tumour sampling was performed but the patient ultimately died as a result of disease. Microscopically, the lesion had areas of glioblastoma mixed with a benign mesenchymal constituent; the former showed hypercellularity, endothelial proliferation, high mitotic activity and necrosis, while the latter showed fascicles of long spindle cells surrounded by collagen and reticulin fibers. With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.

No MeSH data available.


Related in: MedlinePlus