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Cancers with Higher Density of Tumor-Associated Macrophages Were Associated with Poor Survival Rates.

Jung KY, Cho SW, Kim YA, Kim D, Oh BC, Park do J, Park YJ - J Pathol Transl Med (2015)

Bottom Line: The histological subtypes in thyroid cancer exhibited significantly different CD163-positive macrophages densities (papillary, 1.8 ± 1.6% vs anaplastic, 22.9 ± 17.1%; p < .001), but no significant difference between histological subtypes was detected in lung and breast cancers.Moreover, there was no significant difference in CD163-positive macrophages densities among the TNM stages in lung, breast, and thyroid cancers.Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea ; Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.

ABSTRACT

Background: Macrophages are a component of a tumor's microenvironment and have various roles in tumor progression and metastasis. This study evaluated the relationships between tumor-associated macrophage (TAM) density and clinical outcomes in 14 different types of human cancers.

Methods: We investigated TAM density in human tissue microarray sections from 14 different types of human cancers (n = 266) and normal thyroid, lung, and breast tissues (n = 22). The five-year survival rates of each cancer were obtained from the 2011 Korea Central Cancer Registry.

Results: Among 13 human cancers, excluding thyroid cancer, pancreas, lung, and gallbladder cancers had the highest density of CD163-positive macrophages (7.0±3.5%, 6.9±7.4%, and 6.9 ± 5.5%, respectively). The five-year relative survival rates of these cancers (pancreas, 8.7%; lung, 20.7%; gallbladder, 27.5%) were lower than those of other cancers. The histological subtypes in thyroid cancer exhibited significantly different CD163-positive macrophages densities (papillary, 1.8 ± 1.6% vs anaplastic, 22.9 ± 17.1%; p < .001), but no significant difference between histological subtypes was detected in lung and breast cancers. Moreover, there was no significant difference in CD163-positive macrophages densities among the TNM stages in lung, breast, and thyroid cancers.

Conclusions: Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.

No MeSH data available.


Related in: MedlinePlus

CD163-positive macrophage densities and five-year survival rates in 14 different types of human cancers. Left axis and bar graphs represent the average CD163-positive area (%) as mean ± standard error. Right axis and star-shaped markers represent the five-year overall survival (OS, %) obtained from the 2011 Annual Report of Cancer Statistics in Korea. PTC, papillary thyroid cancer; GB, gallbladder; ATC, anaplastic thyroid cancer; NA, not acquired.
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f2-jptm-49-4-318: CD163-positive macrophage densities and five-year survival rates in 14 different types of human cancers. Left axis and bar graphs represent the average CD163-positive area (%) as mean ± standard error. Right axis and star-shaped markers represent the five-year overall survival (OS, %) obtained from the 2011 Annual Report of Cancer Statistics in Korea. PTC, papillary thyroid cancer; GB, gallbladder; ATC, anaplastic thyroid cancer; NA, not acquired.

Mentions: The CD163-positive macrophages densities and the five-year relative survival rates in the 14 different types of human cancers are summarized in Fig. 2. Excluding thyroid cancer, of the 13 other human cancers, pancreas, lung, and gallbladder cancers had the highest density of CD163-positive macrophages (7.0±3.5%, 6.9±7.4%, and 6.9±5.5%, respectively). In contrast, endometrium, prostate, and kidney cancers had the lowest densities of CD163-positive macrophages (3.6±4.6%, 2.8±2.5%, and 2.8±1.8%, respectively). Interestingly, among the tested cancers, five-year relative survival rate (%) was inversely correlated with CD163-positive macrophages density. The five-year overall survival rates of the cancers with highest TAM densities (pancreas, 8.7%; lung, 20.7%; gallbladder and biliary tract, 27.5%) were lower than those of the cancers with the lowest TAM densities (endometrial, 86.5%; kidney, 78.8%; prostate, 92%).


Cancers with Higher Density of Tumor-Associated Macrophages Were Associated with Poor Survival Rates.

Jung KY, Cho SW, Kim YA, Kim D, Oh BC, Park do J, Park YJ - J Pathol Transl Med (2015)

CD163-positive macrophage densities and five-year survival rates in 14 different types of human cancers. Left axis and bar graphs represent the average CD163-positive area (%) as mean ± standard error. Right axis and star-shaped markers represent the five-year overall survival (OS, %) obtained from the 2011 Annual Report of Cancer Statistics in Korea. PTC, papillary thyroid cancer; GB, gallbladder; ATC, anaplastic thyroid cancer; NA, not acquired.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4508569&req=5

f2-jptm-49-4-318: CD163-positive macrophage densities and five-year survival rates in 14 different types of human cancers. Left axis and bar graphs represent the average CD163-positive area (%) as mean ± standard error. Right axis and star-shaped markers represent the five-year overall survival (OS, %) obtained from the 2011 Annual Report of Cancer Statistics in Korea. PTC, papillary thyroid cancer; GB, gallbladder; ATC, anaplastic thyroid cancer; NA, not acquired.
Mentions: The CD163-positive macrophages densities and the five-year relative survival rates in the 14 different types of human cancers are summarized in Fig. 2. Excluding thyroid cancer, of the 13 other human cancers, pancreas, lung, and gallbladder cancers had the highest density of CD163-positive macrophages (7.0±3.5%, 6.9±7.4%, and 6.9±5.5%, respectively). In contrast, endometrium, prostate, and kidney cancers had the lowest densities of CD163-positive macrophages (3.6±4.6%, 2.8±2.5%, and 2.8±1.8%, respectively). Interestingly, among the tested cancers, five-year relative survival rate (%) was inversely correlated with CD163-positive macrophages density. The five-year overall survival rates of the cancers with highest TAM densities (pancreas, 8.7%; lung, 20.7%; gallbladder and biliary tract, 27.5%) were lower than those of the cancers with the lowest TAM densities (endometrial, 86.5%; kidney, 78.8%; prostate, 92%).

Bottom Line: The histological subtypes in thyroid cancer exhibited significantly different CD163-positive macrophages densities (papillary, 1.8 ± 1.6% vs anaplastic, 22.9 ± 17.1%; p < .001), but no significant difference between histological subtypes was detected in lung and breast cancers.Moreover, there was no significant difference in CD163-positive macrophages densities among the TNM stages in lung, breast, and thyroid cancers.Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea ; Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.

ABSTRACT

Background: Macrophages are a component of a tumor's microenvironment and have various roles in tumor progression and metastasis. This study evaluated the relationships between tumor-associated macrophage (TAM) density and clinical outcomes in 14 different types of human cancers.

Methods: We investigated TAM density in human tissue microarray sections from 14 different types of human cancers (n = 266) and normal thyroid, lung, and breast tissues (n = 22). The five-year survival rates of each cancer were obtained from the 2011 Korea Central Cancer Registry.

Results: Among 13 human cancers, excluding thyroid cancer, pancreas, lung, and gallbladder cancers had the highest density of CD163-positive macrophages (7.0±3.5%, 6.9±7.4%, and 6.9 ± 5.5%, respectively). The five-year relative survival rates of these cancers (pancreas, 8.7%; lung, 20.7%; gallbladder, 27.5%) were lower than those of other cancers. The histological subtypes in thyroid cancer exhibited significantly different CD163-positive macrophages densities (papillary, 1.8 ± 1.6% vs anaplastic, 22.9 ± 17.1%; p < .001), but no significant difference between histological subtypes was detected in lung and breast cancers. Moreover, there was no significant difference in CD163-positive macrophages densities among the TNM stages in lung, breast, and thyroid cancers.

Conclusions: Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.

No MeSH data available.


Related in: MedlinePlus