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Inflammatory Pseudotumor of the Spleen.

Georgia M, Rady K, Prince HM - Hematol Rep (2015)

Bottom Line: Isolated splenic inflammatory pseudotumors (IPT) are extremely rare, typically benign, inflammatory lesions with varied clinical presentations that pose a diagnostic challenge to clinicians due to their similarity in appearance to neoplasms.We present the case of a young woman diagnosed with a splenic IPT following investigation for persistent anemia, raised inflammatory markers, and polyclonal hypergammaglobulinemia, whose symptoms resolved completely following splenectomy.This case highlights the need to consider this diagnosis when evaluating patients with a splenic mass of unknown etiology.

View Article: PubMed Central - PubMed

Affiliation: Peninsula Health, Frankston Hospital, Victoria Melbourne, Victoria, Australia.

ABSTRACT
Isolated splenic inflammatory pseudotumors (IPT) are extremely rare, typically benign, inflammatory lesions with varied clinical presentations that pose a diagnostic challenge to clinicians due to their similarity in appearance to neoplasms. We present the case of a young woman diagnosed with a splenic IPT following investigation for persistent anemia, raised inflammatory markers, and polyclonal hypergammaglobulinemia, whose symptoms resolved completely following splenectomy. This case highlights the need to consider this diagnosis when evaluating patients with a splenic mass of unknown etiology.

No MeSH data available.


Related in: MedlinePlus

Positron emission tomography-computed tomography (PET-CT) scan of the abdomen highlighting a lesion with mild fludeoxyglucose-18 uptake on the superior pole of the spleen on PET, with CT verification of a heterogeneous lesion with an area of calcification.
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fig001: Positron emission tomography-computed tomography (PET-CT) scan of the abdomen highlighting a lesion with mild fludeoxyglucose-18 uptake on the superior pole of the spleen on PET, with CT verification of a heterogeneous lesion with an area of calcification.

Mentions: Once again, her hematology, electrolytes, hematinics, autoantibodies and SPEP were checked, and remained unchanged. Viral testing for Human HerpesVirus-8 (HHV-8) and Epstein-Barr virus (EBV) were negative. There was no evidence of lymphadenopathy or hepatosplenomegaly on physical examination. The patient was referred for a positive emission tomography-computed tomography (PET-CT) scan for further investigation, and hopefully exclusion, of malignancy. Unexpectedly, the PET scan identified an area of mild fludeoxyglucose-18 (FDG) uptake in the superior pole of the spleen; this was verified on CT where a heterogeneous lesion with a small area of calcification was noted (Figure 1). On review of her prior MRI, conducted 13 months previously, a similar sized lesion was retrospectively identified (Figure 2). Examination of the bone marrow demonstrated reactive trilineage hematopoiesis with no evidence of lymphoma or plasma cell proliferation.


Inflammatory Pseudotumor of the Spleen.

Georgia M, Rady K, Prince HM - Hematol Rep (2015)

Positron emission tomography-computed tomography (PET-CT) scan of the abdomen highlighting a lesion with mild fludeoxyglucose-18 uptake on the superior pole of the spleen on PET, with CT verification of a heterogeneous lesion with an area of calcification.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508554&req=5

fig001: Positron emission tomography-computed tomography (PET-CT) scan of the abdomen highlighting a lesion with mild fludeoxyglucose-18 uptake on the superior pole of the spleen on PET, with CT verification of a heterogeneous lesion with an area of calcification.
Mentions: Once again, her hematology, electrolytes, hematinics, autoantibodies and SPEP were checked, and remained unchanged. Viral testing for Human HerpesVirus-8 (HHV-8) and Epstein-Barr virus (EBV) were negative. There was no evidence of lymphadenopathy or hepatosplenomegaly on physical examination. The patient was referred for a positive emission tomography-computed tomography (PET-CT) scan for further investigation, and hopefully exclusion, of malignancy. Unexpectedly, the PET scan identified an area of mild fludeoxyglucose-18 (FDG) uptake in the superior pole of the spleen; this was verified on CT where a heterogeneous lesion with a small area of calcification was noted (Figure 1). On review of her prior MRI, conducted 13 months previously, a similar sized lesion was retrospectively identified (Figure 2). Examination of the bone marrow demonstrated reactive trilineage hematopoiesis with no evidence of lymphoma or plasma cell proliferation.

Bottom Line: Isolated splenic inflammatory pseudotumors (IPT) are extremely rare, typically benign, inflammatory lesions with varied clinical presentations that pose a diagnostic challenge to clinicians due to their similarity in appearance to neoplasms.We present the case of a young woman diagnosed with a splenic IPT following investigation for persistent anemia, raised inflammatory markers, and polyclonal hypergammaglobulinemia, whose symptoms resolved completely following splenectomy.This case highlights the need to consider this diagnosis when evaluating patients with a splenic mass of unknown etiology.

View Article: PubMed Central - PubMed

Affiliation: Peninsula Health, Frankston Hospital, Victoria Melbourne, Victoria, Australia.

ABSTRACT
Isolated splenic inflammatory pseudotumors (IPT) are extremely rare, typically benign, inflammatory lesions with varied clinical presentations that pose a diagnostic challenge to clinicians due to their similarity in appearance to neoplasms. We present the case of a young woman diagnosed with a splenic IPT following investigation for persistent anemia, raised inflammatory markers, and polyclonal hypergammaglobulinemia, whose symptoms resolved completely following splenectomy. This case highlights the need to consider this diagnosis when evaluating patients with a splenic mass of unknown etiology.

No MeSH data available.


Related in: MedlinePlus