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Disseminated Cryptococcosis Presenting as Cutaneous Cellulitis in an Adolescent With Systemic Lupus Erythematosus.

Valente ES, Lazzarin MC, Koech BL, da Rosa RV, de Almeida R, de Oliveira UL, Neugebauer MG, Sacco AG - Infect Dis Rep (2015)

Bottom Line: Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs.Her first symptoms were skin lesions that simulated bacterial cellulitis.Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Federal University of Pelotas , Brazil.

ABSTRACT
We report here the case of a 17-year-old girl from Pelotas, Brazil, with systemic lupus erythematosus and disseminated cryptococcal infection. Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs. Her first symptoms were skin lesions that simulated bacterial cellulitis. Upon suspicion, we performed a biopsy and fungal infection was confirmed. Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.

No MeSH data available.


Related in: MedlinePlus

Biopsy of the subcutaneous tissue in Hematoxylin & Eosin (40× magnification). Fungal spores without inflammatory reaction.
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fig001: Biopsy of the subcutaneous tissue in Hematoxylin & Eosin (40× magnification). Fungal spores without inflammatory reaction.

Mentions: A nodular lesion on her RLE was biopsied on the fourth day of hospitalization; pathology of the fibro-fatty tissue fragment was positive for fungi by Grocott’s method, and Hematoxylin and Eosin staining showed collections of spores without a strong inflammatory reaction or evidence of hyphae (Figure 1). Direct mycological examination of the biopsy showed various yeasts with a gelatinous capsule, and the culture in Sabouraud’s medium and Mycosel agar indicated the presence of C. neoformans in intensive growth. Direct examination of the blood culture obtained upon admission was repeated, and it was also positive for C. neoformans.


Disseminated Cryptococcosis Presenting as Cutaneous Cellulitis in an Adolescent With Systemic Lupus Erythematosus.

Valente ES, Lazzarin MC, Koech BL, da Rosa RV, de Almeida R, de Oliveira UL, Neugebauer MG, Sacco AG - Infect Dis Rep (2015)

Biopsy of the subcutaneous tissue in Hematoxylin & Eosin (40× magnification). Fungal spores without inflammatory reaction.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508533&req=5

fig001: Biopsy of the subcutaneous tissue in Hematoxylin & Eosin (40× magnification). Fungal spores without inflammatory reaction.
Mentions: A nodular lesion on her RLE was biopsied on the fourth day of hospitalization; pathology of the fibro-fatty tissue fragment was positive for fungi by Grocott’s method, and Hematoxylin and Eosin staining showed collections of spores without a strong inflammatory reaction or evidence of hyphae (Figure 1). Direct mycological examination of the biopsy showed various yeasts with a gelatinous capsule, and the culture in Sabouraud’s medium and Mycosel agar indicated the presence of C. neoformans in intensive growth. Direct examination of the blood culture obtained upon admission was repeated, and it was also positive for C. neoformans.

Bottom Line: Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs.Her first symptoms were skin lesions that simulated bacterial cellulitis.Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Federal University of Pelotas , Brazil.

ABSTRACT
We report here the case of a 17-year-old girl from Pelotas, Brazil, with systemic lupus erythematosus and disseminated cryptococcal infection. Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs. Her first symptoms were skin lesions that simulated bacterial cellulitis. Upon suspicion, we performed a biopsy and fungal infection was confirmed. Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.

No MeSH data available.


Related in: MedlinePlus