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High frequency synchrony in the cerebellar cortex during goal directed movements.

Groth JD, Sahin M - Front Syst Neurosci (2015)

Bottom Line: Contact groups presented patches with slightly stronger synchrony values in the medio-lateral direction, and did not appear to form parasagittal zones.The size and location of these patches on the cortical surface are in agreement with the sensory evoked granular layer patches originally reported by Welker's lab (Shambes et al., 1978).Spatiotemporal synchrony of high frequency field potentials has not been reported at such large-scales previously in the cerebellar cortex.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, New Jersey Institute of Technology Newark, NJ, USA.

ABSTRACT
The cerebellum is involved in sensory-motor integration and cognitive functions. The origin and function of the field potential oscillations in the cerebellum, especially in the high frequencies, have not been explored sufficiently. The primary objective of this study was to investigate the spatio-temporal characteristics of high frequency field potentials (150-350 Hz) in the cerebellar cortex in a behavioral context. To this end, we recorded from the paramedian lobule in rats using micro electro-corticogram (μ-ECoG) electrode arrays while the animal performed a lever press task using the forelimb. The phase synchrony analysis shows that the high frequency oscillations recorded at multiple points across the paramedian cortex episodically synchronize immediately before and desynchronize during the lever press. The electrode contacts were grouped according to their temporal course of phase synchrony around the time of lever press. Contact groups presented patches with slightly stronger synchrony values in the medio-lateral direction, and did not appear to form parasagittal zones. The size and location of these patches on the cortical surface are in agreement with the sensory evoked granular layer patches originally reported by Welker's lab (Shambes et al., 1978). Spatiotemporal synchrony of high frequency field potentials has not been reported at such large-scales previously in the cerebellar cortex.

No MeSH data available.


Related in: MedlinePlus

Synchrony values as a function of inter-contact distance and orientation. The synchrony on average decreases slightly by distance in both directions. Medio-laterally oriented contacts (in blue) have a slightly higher (*significance, p < 0.01) synchrony than rostra-caudal ones (yellow) for inter-contact distances of 0.6 and 0.9 mm in all three animals, and also for 0.3 mm in the first rat. Other inter-contact separations in the rostra-caudal direction are not available for comparison. The number of trials in each animal are the same as in Figure 8.
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Figure 10: Synchrony values as a function of inter-contact distance and orientation. The synchrony on average decreases slightly by distance in both directions. Medio-laterally oriented contacts (in blue) have a slightly higher (*significance, p < 0.01) synchrony than rostra-caudal ones (yellow) for inter-contact distances of 0.6 and 0.9 mm in all three animals, and also for 0.3 mm in the first rat. Other inter-contact separations in the rostra-caudal direction are not available for comparison. The number of trials in each animal are the same as in Figure 8.

Mentions: In order to investigate if some contacts synchronized and followed a similar synchrony trend in time as a group, we applied the clustering analysis to the synchrony values from each contact (or recording channel) as a function of time (see Methods). The clustering of contacts from two different animals is presented in Figure 9. The plots represent the two largest clusters for each animal where the membership strengths (SM) are color coded. The contacts within the same group are contiguous in the bottom plot but not in the top (blue group is divided). There does not appear to be any directional orientation in synchrony in these maps. A statistical analysis, however, suggests slightly higher synchrony values in the medio-lateral direction (Figure 10). This analysis also clearly demonstrates that the synchrony values decrease very slowly as a function of inter-contact distance.


High frequency synchrony in the cerebellar cortex during goal directed movements.

Groth JD, Sahin M - Front Syst Neurosci (2015)

Synchrony values as a function of inter-contact distance and orientation. The synchrony on average decreases slightly by distance in both directions. Medio-laterally oriented contacts (in blue) have a slightly higher (*significance, p < 0.01) synchrony than rostra-caudal ones (yellow) for inter-contact distances of 0.6 and 0.9 mm in all three animals, and also for 0.3 mm in the first rat. Other inter-contact separations in the rostra-caudal direction are not available for comparison. The number of trials in each animal are the same as in Figure 8.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508504&req=5

Figure 10: Synchrony values as a function of inter-contact distance and orientation. The synchrony on average decreases slightly by distance in both directions. Medio-laterally oriented contacts (in blue) have a slightly higher (*significance, p < 0.01) synchrony than rostra-caudal ones (yellow) for inter-contact distances of 0.6 and 0.9 mm in all three animals, and also for 0.3 mm in the first rat. Other inter-contact separations in the rostra-caudal direction are not available for comparison. The number of trials in each animal are the same as in Figure 8.
Mentions: In order to investigate if some contacts synchronized and followed a similar synchrony trend in time as a group, we applied the clustering analysis to the synchrony values from each contact (or recording channel) as a function of time (see Methods). The clustering of contacts from two different animals is presented in Figure 9. The plots represent the two largest clusters for each animal where the membership strengths (SM) are color coded. The contacts within the same group are contiguous in the bottom plot but not in the top (blue group is divided). There does not appear to be any directional orientation in synchrony in these maps. A statistical analysis, however, suggests slightly higher synchrony values in the medio-lateral direction (Figure 10). This analysis also clearly demonstrates that the synchrony values decrease very slowly as a function of inter-contact distance.

Bottom Line: Contact groups presented patches with slightly stronger synchrony values in the medio-lateral direction, and did not appear to form parasagittal zones.The size and location of these patches on the cortical surface are in agreement with the sensory evoked granular layer patches originally reported by Welker's lab (Shambes et al., 1978).Spatiotemporal synchrony of high frequency field potentials has not been reported at such large-scales previously in the cerebellar cortex.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, New Jersey Institute of Technology Newark, NJ, USA.

ABSTRACT
The cerebellum is involved in sensory-motor integration and cognitive functions. The origin and function of the field potential oscillations in the cerebellum, especially in the high frequencies, have not been explored sufficiently. The primary objective of this study was to investigate the spatio-temporal characteristics of high frequency field potentials (150-350 Hz) in the cerebellar cortex in a behavioral context. To this end, we recorded from the paramedian lobule in rats using micro electro-corticogram (μ-ECoG) electrode arrays while the animal performed a lever press task using the forelimb. The phase synchrony analysis shows that the high frequency oscillations recorded at multiple points across the paramedian cortex episodically synchronize immediately before and desynchronize during the lever press. The electrode contacts were grouped according to their temporal course of phase synchrony around the time of lever press. Contact groups presented patches with slightly stronger synchrony values in the medio-lateral direction, and did not appear to form parasagittal zones. The size and location of these patches on the cortical surface are in agreement with the sensory evoked granular layer patches originally reported by Welker's lab (Shambes et al., 1978). Spatiotemporal synchrony of high frequency field potentials has not been reported at such large-scales previously in the cerebellar cortex.

No MeSH data available.


Related in: MedlinePlus