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Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency.

Anno M, Yamazaki T, Hara N, Hayakawa K - Case Rep Orthop (2015)

Bottom Line: Congenital Protein S deficiency was diagnosed postoperatively.Protein S is a vitamin K-dependent natural anticoagulant and is essential for inhibiting thrombosis in microcirculation.We assume that Protein S deficiency followed by perioperative bed-rest and surgical invasiveness led to severe hypercoagulability and subsequent drain obstruction.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shi, Tokyo 1800023, Japan.

ABSTRACT
A 71-year-old man underwent cervical laminectomy and developed two symptomatic epidural hematomas during the acute postoperative period. On both occasions, drain obstruction was the predominant cause. Congenital Protein S deficiency was diagnosed postoperatively. Protein S is a vitamin K-dependent natural anticoagulant and is essential for inhibiting thrombosis in microcirculation. We assume that Protein S deficiency followed by perioperative bed-rest and surgical invasiveness led to severe hypercoagulability and subsequent drain obstruction. The present findings suggest that both bleeding disorders and hypercoagulability are risk factors for postoperative symptomatic epidural hematoma.

No MeSH data available.


Related in: MedlinePlus

Magnetic resonance image showing C3–C7 degenerative spondylosis with mild central canal stenosis and high-signal lesions at C4/5.
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fig1: Magnetic resonance image showing C3–C7 degenerative spondylosis with mild central canal stenosis and high-signal lesions at C4/5.

Mentions: Magnetic resonance imaging (MRI) of the cervical spine showed C3–C7 degenerative spondylosis with mild central canal stenosis and high-signal lesions in the spinal cord (Figure 1). Findings from other examinations were unremarkable. Surgical decompression was advised.


Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency.

Anno M, Yamazaki T, Hara N, Hayakawa K - Case Rep Orthop (2015)

Magnetic resonance image showing C3–C7 degenerative spondylosis with mild central canal stenosis and high-signal lesions at C4/5.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4508477&req=5

fig1: Magnetic resonance image showing C3–C7 degenerative spondylosis with mild central canal stenosis and high-signal lesions at C4/5.
Mentions: Magnetic resonance imaging (MRI) of the cervical spine showed C3–C7 degenerative spondylosis with mild central canal stenosis and high-signal lesions in the spinal cord (Figure 1). Findings from other examinations were unremarkable. Surgical decompression was advised.

Bottom Line: Congenital Protein S deficiency was diagnosed postoperatively.Protein S is a vitamin K-dependent natural anticoagulant and is essential for inhibiting thrombosis in microcirculation.We assume that Protein S deficiency followed by perioperative bed-rest and surgical invasiveness led to severe hypercoagulability and subsequent drain obstruction.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shi, Tokyo 1800023, Japan.

ABSTRACT
A 71-year-old man underwent cervical laminectomy and developed two symptomatic epidural hematomas during the acute postoperative period. On both occasions, drain obstruction was the predominant cause. Congenital Protein S deficiency was diagnosed postoperatively. Protein S is a vitamin K-dependent natural anticoagulant and is essential for inhibiting thrombosis in microcirculation. We assume that Protein S deficiency followed by perioperative bed-rest and surgical invasiveness led to severe hypercoagulability and subsequent drain obstruction. The present findings suggest that both bleeding disorders and hypercoagulability are risk factors for postoperative symptomatic epidural hematoma.

No MeSH data available.


Related in: MedlinePlus