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Eccrine Spiradenoma Arising from the Breast Skin.

Benedict MA, Ozerdem U - Case Rep Pathol (2015)

Bottom Line: They are common in young adults and are without a sex predilection.Here we report a case of eccrine spiradenoma of the breast skin in a 39-year-old woman who presented with a breast nodule for 10 years.It is useful to recognize the two-cell populations constituting this tumor: small, dark, basaloid cells with hyperchromatic nuclei, which are immunoreactive for P63 and calponin, and larger cells with a pale nucleus, often near the center of the cluster (inner cells), which are immunoreactive for CK7 and CD117 (C-kit).

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.

ABSTRACT
Eccrine spiradenomas are uncommon, benign lesions, which are thought to originate from the eccrine sweat glands. They are common in young adults and are without a sex predilection. Here we report a case of eccrine spiradenoma of the breast skin in a 39-year-old woman who presented with a breast nodule for 10 years. It is crucial to take eccrine spiradenoma into consideration in superficial, well-circumscribed, breast skin/subcutaneous lesions. It is useful to recognize the two-cell populations constituting this tumor: small, dark, basaloid cells with hyperchromatic nuclei, which are immunoreactive for P63 and calponin, and larger cells with a pale nucleus, often near the center of the cluster (inner cells), which are immunoreactive for CK7 and CD117 (C-kit).

No MeSH data available.


Related in: MedlinePlus

Eccrine spiradenoma of breast. The tumor is located at the interface of the deep dermis and superficial breast tissue, well-circumscribed with a thick fibrotic capsule (a and b). Two-cell populations within the tumor clusters are identified with dark-grey and light-grey nuclei being evident. The two-cell populations constituting this tumor: small dark and basaloid cells with hyperchromatic nuclei and larger cells with a pale nucleus, often near the center of the cluster.
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fig1: Eccrine spiradenoma of breast. The tumor is located at the interface of the deep dermis and superficial breast tissue, well-circumscribed with a thick fibrotic capsule (a and b). Two-cell populations within the tumor clusters are identified with dark-grey and light-grey nuclei being evident. The two-cell populations constituting this tumor: small dark and basaloid cells with hyperchromatic nuclei and larger cells with a pale nucleus, often near the center of the cluster.

Mentions: An excisional biopsy of the left breast lesion has revealed a tan-white, well-circumscribed predominantly solid mass with no evidence of invasion into the surrounding tissue. Histologically, the tumor is located at the interface of the deep dermis and superficial breast tissue. Microscopically, the lesion has displayed mostly solid and focally cystic architecture. Two-cell populations within the tumor clusters are identified with dark-grey nuclei (basaloid cells) and with light-grey larger nuclei (inner cells) (Figure 1). Cytological atypia, necrosis, and mitoses are not appreciated. Scattered lymphocytes were seen amongst the tumor cell clusters as well as focal hyaline droplets in the stroma. These two- cell populations are immunoreactive for P63 and CK7, respectively. Most of the P63-immunoreactive basaloid cells also show immunoreactivity for calponin. CK7-immunoreactive inner cells display CD117 immunoreactivity (Figure 2). The tumor cells are quadruple-negative, that is, negative for ER, PR, AR, and HER2 on immunohistochemistry (not shown).


Eccrine Spiradenoma Arising from the Breast Skin.

Benedict MA, Ozerdem U - Case Rep Pathol (2015)

Eccrine spiradenoma of breast. The tumor is located at the interface of the deep dermis and superficial breast tissue, well-circumscribed with a thick fibrotic capsule (a and b). Two-cell populations within the tumor clusters are identified with dark-grey and light-grey nuclei being evident. The two-cell populations constituting this tumor: small dark and basaloid cells with hyperchromatic nuclei and larger cells with a pale nucleus, often near the center of the cluster.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4508467&req=5

fig1: Eccrine spiradenoma of breast. The tumor is located at the interface of the deep dermis and superficial breast tissue, well-circumscribed with a thick fibrotic capsule (a and b). Two-cell populations within the tumor clusters are identified with dark-grey and light-grey nuclei being evident. The two-cell populations constituting this tumor: small dark and basaloid cells with hyperchromatic nuclei and larger cells with a pale nucleus, often near the center of the cluster.
Mentions: An excisional biopsy of the left breast lesion has revealed a tan-white, well-circumscribed predominantly solid mass with no evidence of invasion into the surrounding tissue. Histologically, the tumor is located at the interface of the deep dermis and superficial breast tissue. Microscopically, the lesion has displayed mostly solid and focally cystic architecture. Two-cell populations within the tumor clusters are identified with dark-grey nuclei (basaloid cells) and with light-grey larger nuclei (inner cells) (Figure 1). Cytological atypia, necrosis, and mitoses are not appreciated. Scattered lymphocytes were seen amongst the tumor cell clusters as well as focal hyaline droplets in the stroma. These two- cell populations are immunoreactive for P63 and CK7, respectively. Most of the P63-immunoreactive basaloid cells also show immunoreactivity for calponin. CK7-immunoreactive inner cells display CD117 immunoreactivity (Figure 2). The tumor cells are quadruple-negative, that is, negative for ER, PR, AR, and HER2 on immunohistochemistry (not shown).

Bottom Line: They are common in young adults and are without a sex predilection.Here we report a case of eccrine spiradenoma of the breast skin in a 39-year-old woman who presented with a breast nodule for 10 years.It is useful to recognize the two-cell populations constituting this tumor: small, dark, basaloid cells with hyperchromatic nuclei, which are immunoreactive for P63 and calponin, and larger cells with a pale nucleus, often near the center of the cluster (inner cells), which are immunoreactive for CK7 and CD117 (C-kit).

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.

ABSTRACT
Eccrine spiradenomas are uncommon, benign lesions, which are thought to originate from the eccrine sweat glands. They are common in young adults and are without a sex predilection. Here we report a case of eccrine spiradenoma of the breast skin in a 39-year-old woman who presented with a breast nodule for 10 years. It is crucial to take eccrine spiradenoma into consideration in superficial, well-circumscribed, breast skin/subcutaneous lesions. It is useful to recognize the two-cell populations constituting this tumor: small, dark, basaloid cells with hyperchromatic nuclei, which are immunoreactive for P63 and calponin, and larger cells with a pale nucleus, often near the center of the cluster (inner cells), which are immunoreactive for CK7 and CD117 (C-kit).

No MeSH data available.


Related in: MedlinePlus