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The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study.

Anders KL, Thompson CN, Thuy NT, Nguyet NM, Tu le TP, Dung TT, Phat VV, Van NT, Hieu NT, Tham NT, Ha PT, Lien le B, Chau NV, Baker S, Simmons CP - Int. J. Infect. Dis. (2015)

Bottom Line: Repeat infections were identified in 9% of infants infected with rotavirus, norovirus, Shigella, or Campylobacter, and 13% of those with Salmonella infections.A large proportion of laboratory-diagnosed disease was caused by rotavirus and norovirus.These data highlight the unmet need for a rotavirus vaccine in Vietnam and provide evidence of the previously unrecognized burden of norovirus in infants.

View Article: PubMed Central - PubMed

Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, 764 Vo Van Kiet, District 5, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address: katieanders99@gmail.com.

No MeSH data available.


Related in: MedlinePlus

Spatial clustering of diarrhoeal cases in Dong Thap Province. (A) Vietnam is shown in grey, with Ho Chi Minh City (HCMC) indicated with the black cross and Dong Thap indicated with the red cross. (B) Location of Dong Thap Province, with the hospital indicated by the red cross. (C) Locations of households with diarrhoea shown with coloured points, as follows: blue, rotavirus; green, norovirus; red, Shigella; orange, Salmonella; purple, Campylobacter. Grey points show the locations of the households of children in the cohort for whom diarrhoea was not reported during the period of follow-up. Shaded circles indicate the location of the significant clusters, with colours corresponding to the individual pathogens listed above. The red cross shows the location of Dong Thap Provincial Hospital. Grey borders show the borders of Cao Lanh district (large border) and Cao Lanh town (small, embedded border). Actual household locations have been jittered for display on the map.
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fig0015: Spatial clustering of diarrhoeal cases in Dong Thap Province. (A) Vietnam is shown in grey, with Ho Chi Minh City (HCMC) indicated with the black cross and Dong Thap indicated with the red cross. (B) Location of Dong Thap Province, with the hospital indicated by the red cross. (C) Locations of households with diarrhoea shown with coloured points, as follows: blue, rotavirus; green, norovirus; red, Shigella; orange, Salmonella; purple, Campylobacter. Grey points show the locations of the households of children in the cohort for whom diarrhoea was not reported during the period of follow-up. Shaded circles indicate the location of the significant clusters, with colours corresponding to the individual pathogens listed above. The red cross shows the location of Dong Thap Provincial Hospital. Grey borders show the borders of Cao Lanh district (large border) and Cao Lanh town (small, embedded border). Actual household locations have been jittered for display on the map.

Mentions: As shown in Figure 3, in Dong Thap there was evidence of spatial clustering for each detected pathogen. For all-cause diarrhoea, a cluster was identified with a radius of 6.7 km in the northwest region of the study area (relative risk (RR) 1.79, p < 0.001). All of the pathogen-specific clusters centred generally around the same area, in the more rural part of the Dong Thap study area, with radii ranging from 6.6 km (rotavirus) to 12.4 km (Campylobacter) and RRs from 2.3 (rotavirus) to 3.7 (Shigella). No significant spatial clustering was identified in HCMC (data not shown).


The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study.

Anders KL, Thompson CN, Thuy NT, Nguyet NM, Tu le TP, Dung TT, Phat VV, Van NT, Hieu NT, Tham NT, Ha PT, Lien le B, Chau NV, Baker S, Simmons CP - Int. J. Infect. Dis. (2015)

Spatial clustering of diarrhoeal cases in Dong Thap Province. (A) Vietnam is shown in grey, with Ho Chi Minh City (HCMC) indicated with the black cross and Dong Thap indicated with the red cross. (B) Location of Dong Thap Province, with the hospital indicated by the red cross. (C) Locations of households with diarrhoea shown with coloured points, as follows: blue, rotavirus; green, norovirus; red, Shigella; orange, Salmonella; purple, Campylobacter. Grey points show the locations of the households of children in the cohort for whom diarrhoea was not reported during the period of follow-up. Shaded circles indicate the location of the significant clusters, with colours corresponding to the individual pathogens listed above. The red cross shows the location of Dong Thap Provincial Hospital. Grey borders show the borders of Cao Lanh district (large border) and Cao Lanh town (small, embedded border). Actual household locations have been jittered for display on the map.
© Copyright Policy - CC BY
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4508461&req=5

fig0015: Spatial clustering of diarrhoeal cases in Dong Thap Province. (A) Vietnam is shown in grey, with Ho Chi Minh City (HCMC) indicated with the black cross and Dong Thap indicated with the red cross. (B) Location of Dong Thap Province, with the hospital indicated by the red cross. (C) Locations of households with diarrhoea shown with coloured points, as follows: blue, rotavirus; green, norovirus; red, Shigella; orange, Salmonella; purple, Campylobacter. Grey points show the locations of the households of children in the cohort for whom diarrhoea was not reported during the period of follow-up. Shaded circles indicate the location of the significant clusters, with colours corresponding to the individual pathogens listed above. The red cross shows the location of Dong Thap Provincial Hospital. Grey borders show the borders of Cao Lanh district (large border) and Cao Lanh town (small, embedded border). Actual household locations have been jittered for display on the map.
Mentions: As shown in Figure 3, in Dong Thap there was evidence of spatial clustering for each detected pathogen. For all-cause diarrhoea, a cluster was identified with a radius of 6.7 km in the northwest region of the study area (relative risk (RR) 1.79, p < 0.001). All of the pathogen-specific clusters centred generally around the same area, in the more rural part of the Dong Thap study area, with radii ranging from 6.6 km (rotavirus) to 12.4 km (Campylobacter) and RRs from 2.3 (rotavirus) to 3.7 (Shigella). No significant spatial clustering was identified in HCMC (data not shown).

Bottom Line: Repeat infections were identified in 9% of infants infected with rotavirus, norovirus, Shigella, or Campylobacter, and 13% of those with Salmonella infections.A large proportion of laboratory-diagnosed disease was caused by rotavirus and norovirus.These data highlight the unmet need for a rotavirus vaccine in Vietnam and provide evidence of the previously unrecognized burden of norovirus in infants.

View Article: PubMed Central - PubMed

Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, 764 Vo Van Kiet, District 5, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address: katieanders99@gmail.com.

No MeSH data available.


Related in: MedlinePlus