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Diverse Roles of Heparan Sulfate and Heparin in Wound Repair.

Olczyk P, Mencner Ł, Komosinska-Vassev K - Biomed Res Int (2015)

Bottom Line: Heparan sulfate (HS) and heparin (Hp) are linear polysaccharide chains composed of repeating (1→4) linked pyrosulfuric acid and 2-amino-2-deoxy glucopyranose (glucosamine) residue.Mentioned glycosaminoglycans chains are covalently O-linked to serine residues within the core proteins creating heparan sulfate/heparin proteoglycans (HSPG).Moreover, HS/Hp determine the effective wound healing process.

View Article: PubMed Central - PubMed

Affiliation: Department of Community Pharmacy, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland.

ABSTRACT
Heparan sulfate (HS) and heparin (Hp) are linear polysaccharide chains composed of repeating (1→4) linked pyrosulfuric acid and 2-amino-2-deoxy glucopyranose (glucosamine) residue. Mentioned glycosaminoglycans chains are covalently O-linked to serine residues within the core proteins creating heparan sulfate/heparin proteoglycans (HSPG). The latter ones participate in many physiological and pathological phenomena impacting both the plethora of ligands such as cytokines, growth factors, and adhesion molecules and the variety of the ECM constituents. Moreover, HS/Hp determine the effective wound healing process. Initial growth of HS and Hp amount is pivotal during the early phase of tissue repair; however heparan sulfate and heparin also participate in further stages of tissue regeneration.

No MeSH data available.


Related in: MedlinePlus

Structure of heparan sulfate/heparin disaccharides [13].
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Structure of heparan sulfate/heparin disaccharides [13].

Mentions: Heparan sulfate (HS) and heparin (Hp) are the glycosaminoglycans (GAGs) of the most complex structure among all GAGs. They are made of recurring, disaccharide units consisting of glucuronic acid and N-acetylglucosamine residues of a schematic structure [→4GlcAβ1→GlcNAcα1→], in which the glycosidic bond between the hexuronic acid and N-acetylglucosamine assumes the configuration of β1→4 instead of β1→3, while the bond between N-acetylglucosamine and hexuronic acid assumes the configuration cα1→4 instead of β1→4, as it takes place in chondroitin-dermatan glycosaminoglycans [11, 13–16]. HS/Hp structures are presented in Figure 1.


Diverse Roles of Heparan Sulfate and Heparin in Wound Repair.

Olczyk P, Mencner Ł, Komosinska-Vassev K - Biomed Res Int (2015)

Structure of heparan sulfate/heparin disaccharides [13].
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4508384&req=5

fig1: Structure of heparan sulfate/heparin disaccharides [13].
Mentions: Heparan sulfate (HS) and heparin (Hp) are the glycosaminoglycans (GAGs) of the most complex structure among all GAGs. They are made of recurring, disaccharide units consisting of glucuronic acid and N-acetylglucosamine residues of a schematic structure [→4GlcAβ1→GlcNAcα1→], in which the glycosidic bond between the hexuronic acid and N-acetylglucosamine assumes the configuration of β1→4 instead of β1→3, while the bond between N-acetylglucosamine and hexuronic acid assumes the configuration cα1→4 instead of β1→4, as it takes place in chondroitin-dermatan glycosaminoglycans [11, 13–16]. HS/Hp structures are presented in Figure 1.

Bottom Line: Heparan sulfate (HS) and heparin (Hp) are linear polysaccharide chains composed of repeating (1→4) linked pyrosulfuric acid and 2-amino-2-deoxy glucopyranose (glucosamine) residue.Mentioned glycosaminoglycans chains are covalently O-linked to serine residues within the core proteins creating heparan sulfate/heparin proteoglycans (HSPG).Moreover, HS/Hp determine the effective wound healing process.

View Article: PubMed Central - PubMed

Affiliation: Department of Community Pharmacy, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland.

ABSTRACT
Heparan sulfate (HS) and heparin (Hp) are linear polysaccharide chains composed of repeating (1→4) linked pyrosulfuric acid and 2-amino-2-deoxy glucopyranose (glucosamine) residue. Mentioned glycosaminoglycans chains are covalently O-linked to serine residues within the core proteins creating heparan sulfate/heparin proteoglycans (HSPG). The latter ones participate in many physiological and pathological phenomena impacting both the plethora of ligands such as cytokines, growth factors, and adhesion molecules and the variety of the ECM constituents. Moreover, HS/Hp determine the effective wound healing process. Initial growth of HS and Hp amount is pivotal during the early phase of tissue repair; however heparan sulfate and heparin also participate in further stages of tissue regeneration.

No MeSH data available.


Related in: MedlinePlus