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Applying refinement to the use of mice and rats in rheumatoid arthritis research.

Hawkins P, Armstrong R, Boden T, Garside P, Knight K, Lilley E, Seed M, Wilkinson M, Williams RO - Inflammopharmacology (2015)

Bottom Line: Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients.The research and development process for therapies and treatments currently involves in vivo studies, which have the potential to cause discomfort, pain or distress.This Working Group report focuses on identifying causes of suffering within commonly used mouse and rat 'models' of RA, describing practical refinements to help reduce suffering and improve welfare without compromising the scientific objectives.

View Article: PubMed Central - PubMed

Affiliation: Research Animals Department, RSPCA, Wilberforce Way, Southwater, West Sussex, RH13 9RS, UK, penny.hawkins@rspca.org.uk.

ABSTRACT
Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo studies, which have the potential to cause discomfort, pain or distress. This Working Group report focuses on identifying causes of suffering within commonly used mouse and rat 'models' of RA, describing practical refinements to help reduce suffering and improve welfare without compromising the scientific objectives. The report also discusses other, relevant topics including identifying and minimising sources of variation within in vivo RA studies, the potential to provide pain relief including analgesia, welfare assessment, humane endpoints, reporting standards and the potential to replace animals in RA research.

No MeSH data available.


Related in: MedlinePlus

System for recording paw scores. An example of a scoring system that can be used in pilot rodent trials to determine the pattern of disease expression and evaluate different scoring systems and determine power. The top rows represent the digits, second rows are the knuckles, and third and fourth rows are the midfoot and ankle/wrist respectively. The scores in this case are: left front 4, right front 0, left hind 4, right hind 3 (courtesy M. Seed, University of East London)
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Fig3: System for recording paw scores. An example of a scoring system that can be used in pilot rodent trials to determine the pattern of disease expression and evaluate different scoring systems and determine power. The top rows represent the digits, second rows are the knuckles, and third and fourth rows are the midfoot and ankle/wrist respectively. The scores in this case are: left front 4, right front 0, left hind 4, right hind 3 (courtesy M. Seed, University of East London)

Mentions: An example approach to visually monitoring clinical scores of the hind paws in pristane adjuvant arthritic rats is outlined below (Table 5; Fig. 3). In this trial, all joints were assessed in order to determine an optimal scoring system relevant to that model, as different joints develop and resolve arthritis at different times.Table 5


Applying refinement to the use of mice and rats in rheumatoid arthritis research.

Hawkins P, Armstrong R, Boden T, Garside P, Knight K, Lilley E, Seed M, Wilkinson M, Williams RO - Inflammopharmacology (2015)

System for recording paw scores. An example of a scoring system that can be used in pilot rodent trials to determine the pattern of disease expression and evaluate different scoring systems and determine power. The top rows represent the digits, second rows are the knuckles, and third and fourth rows are the midfoot and ankle/wrist respectively. The scores in this case are: left front 4, right front 0, left hind 4, right hind 3 (courtesy M. Seed, University of East London)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508365&req=5

Fig3: System for recording paw scores. An example of a scoring system that can be used in pilot rodent trials to determine the pattern of disease expression and evaluate different scoring systems and determine power. The top rows represent the digits, second rows are the knuckles, and third and fourth rows are the midfoot and ankle/wrist respectively. The scores in this case are: left front 4, right front 0, left hind 4, right hind 3 (courtesy M. Seed, University of East London)
Mentions: An example approach to visually monitoring clinical scores of the hind paws in pristane adjuvant arthritic rats is outlined below (Table 5; Fig. 3). In this trial, all joints were assessed in order to determine an optimal scoring system relevant to that model, as different joints develop and resolve arthritis at different times.Table 5

Bottom Line: Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients.The research and development process for therapies and treatments currently involves in vivo studies, which have the potential to cause discomfort, pain or distress.This Working Group report focuses on identifying causes of suffering within commonly used mouse and rat 'models' of RA, describing practical refinements to help reduce suffering and improve welfare without compromising the scientific objectives.

View Article: PubMed Central - PubMed

Affiliation: Research Animals Department, RSPCA, Wilberforce Way, Southwater, West Sussex, RH13 9RS, UK, penny.hawkins@rspca.org.uk.

ABSTRACT
Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo studies, which have the potential to cause discomfort, pain or distress. This Working Group report focuses on identifying causes of suffering within commonly used mouse and rat 'models' of RA, describing practical refinements to help reduce suffering and improve welfare without compromising the scientific objectives. The report also discusses other, relevant topics including identifying and minimising sources of variation within in vivo RA studies, the potential to provide pain relief including analgesia, welfare assessment, humane endpoints, reporting standards and the potential to replace animals in RA research.

No MeSH data available.


Related in: MedlinePlus