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A history of the term "DMARD".

Buer JK - Inflammopharmacology (2015)

Bottom Line: It then examines the usage of the terms "remission-inducing drugs" (RIDs) and "slow-acting anti-rheumatic drugs" (SAARDs), which for some years offered competition to the term DMARDs, thus underscoring the contingency of the establishment of DMARD as a word.Finally, it juxtaposes the apparently spontaneous emergence of the three terms DMARD, SAARD and RID, and the disappearance of the latter two, with a failed attempt in the early 1990s to replace these terms with the new term "disease-controlling antirheumatic treatment" (DC-ART).The analysis highlights the paradoxical qualities of the DMARD concept as robust albeit tension ridden, while playing down the role of identified individuals and overarching explanations of purpose.

View Article: PubMed Central - PubMed

Affiliation: Department of Social Anthropology, University of Oslo, Blindern, Postboks 1091, 0317, Oslo, Norway, j.k.buer@sai.uio.no.

ABSTRACT
The article outlines a history of the concept of "disease-modifying antirheumatic drugs" or DMARDs--from the emergence in the 1970s of the idea of drugs with decisive long-term effects on bone erosion in rheumatoid arthritis (RA), through the consolidation and popularisation in the term DMARD in 1980s and 1990s. It then examines the usage of the terms "remission-inducing drugs" (RIDs) and "slow-acting anti-rheumatic drugs" (SAARDs), which for some years offered competition to the term DMARDs, thus underscoring the contingency of the establishment of DMARD as a word. Finally, it juxtaposes the apparently spontaneous emergence of the three terms DMARD, SAARD and RID, and the disappearance of the latter two, with a failed attempt in the early 1990s to replace these terms with the new term "disease-controlling antirheumatic treatment" (DC-ART). The analysis highlights the paradoxical qualities of the DMARD concept as robust albeit tension ridden, while playing down the role of identified individuals and overarching explanations of purpose.

No MeSH data available.


Related in: MedlinePlus

Earliest appearance of the expression “disease-modifying” in the PubMed database. With permission from Gumpel (1976), Rheumatology, Oxford University Press
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Fig1: Earliest appearance of the expression “disease-modifying” in the PubMed database. With permission from Gumpel (1976), Rheumatology, Oxford University Press

Mentions: The earliest use of the term “disease-modifying” that the PubMed (“all fields”) search identified was the article “Cyclophosphamide, gold and penicillamine—disease-modifying drugs in rheumatoid arthritis—tailored dosage and ultimate success” (Gumpel 1976, see Fig. 1). A closer look at the usage of the phrase in that article makes it clear that that phrase was already established when Gumpel chose to use it in his article. In PubMed, however, there is meagre evidence of its use at the time. Except for an article about influenza vaccines (Jovanovic et al. 1979), I identified no other publications containing the phrase until the beginning of the 1980s. Then, however, this changed. Three publications from 1980 contained the phrase “disease-modifying” in either title or abstract (Hunneyball 1980; McConkey et al. 1980; Bunch and O’Duffy 1980). Although my search revealed no publications from 1981 containing the phrase “disease-modifying”, the phrase reappeared in five publications from 1982 (van Wanghe and Dequeker 1982; Barnes 1982; Paulus 1982; Whisnant and Pelkey 1982; Rainsford 1982). From then on, the frequency increased: from 1983, 10 publications; 14 from 1984, 13 from 1985 and so on. Clearly, between 1980 and 1982, something had happened: the idea of disease-modifying drugs had gained momentum.Fig. 1


A history of the term "DMARD".

Buer JK - Inflammopharmacology (2015)

Earliest appearance of the expression “disease-modifying” in the PubMed database. With permission from Gumpel (1976), Rheumatology, Oxford University Press
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4508364&req=5

Fig1: Earliest appearance of the expression “disease-modifying” in the PubMed database. With permission from Gumpel (1976), Rheumatology, Oxford University Press
Mentions: The earliest use of the term “disease-modifying” that the PubMed (“all fields”) search identified was the article “Cyclophosphamide, gold and penicillamine—disease-modifying drugs in rheumatoid arthritis—tailored dosage and ultimate success” (Gumpel 1976, see Fig. 1). A closer look at the usage of the phrase in that article makes it clear that that phrase was already established when Gumpel chose to use it in his article. In PubMed, however, there is meagre evidence of its use at the time. Except for an article about influenza vaccines (Jovanovic et al. 1979), I identified no other publications containing the phrase until the beginning of the 1980s. Then, however, this changed. Three publications from 1980 contained the phrase “disease-modifying” in either title or abstract (Hunneyball 1980; McConkey et al. 1980; Bunch and O’Duffy 1980). Although my search revealed no publications from 1981 containing the phrase “disease-modifying”, the phrase reappeared in five publications from 1982 (van Wanghe and Dequeker 1982; Barnes 1982; Paulus 1982; Whisnant and Pelkey 1982; Rainsford 1982). From then on, the frequency increased: from 1983, 10 publications; 14 from 1984, 13 from 1985 and so on. Clearly, between 1980 and 1982, something had happened: the idea of disease-modifying drugs had gained momentum.Fig. 1

Bottom Line: It then examines the usage of the terms "remission-inducing drugs" (RIDs) and "slow-acting anti-rheumatic drugs" (SAARDs), which for some years offered competition to the term DMARDs, thus underscoring the contingency of the establishment of DMARD as a word.Finally, it juxtaposes the apparently spontaneous emergence of the three terms DMARD, SAARD and RID, and the disappearance of the latter two, with a failed attempt in the early 1990s to replace these terms with the new term "disease-controlling antirheumatic treatment" (DC-ART).The analysis highlights the paradoxical qualities of the DMARD concept as robust albeit tension ridden, while playing down the role of identified individuals and overarching explanations of purpose.

View Article: PubMed Central - PubMed

Affiliation: Department of Social Anthropology, University of Oslo, Blindern, Postboks 1091, 0317, Oslo, Norway, j.k.buer@sai.uio.no.

ABSTRACT
The article outlines a history of the concept of "disease-modifying antirheumatic drugs" or DMARDs--from the emergence in the 1970s of the idea of drugs with decisive long-term effects on bone erosion in rheumatoid arthritis (RA), through the consolidation and popularisation in the term DMARD in 1980s and 1990s. It then examines the usage of the terms "remission-inducing drugs" (RIDs) and "slow-acting anti-rheumatic drugs" (SAARDs), which for some years offered competition to the term DMARDs, thus underscoring the contingency of the establishment of DMARD as a word. Finally, it juxtaposes the apparently spontaneous emergence of the three terms DMARD, SAARD and RID, and the disappearance of the latter two, with a failed attempt in the early 1990s to replace these terms with the new term "disease-controlling antirheumatic treatment" (DC-ART). The analysis highlights the paradoxical qualities of the DMARD concept as robust albeit tension ridden, while playing down the role of identified individuals and overarching explanations of purpose.

No MeSH data available.


Related in: MedlinePlus