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High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men.

Biabangard Zak A, Golalipour M, Hadadchi G - Avicenna J Med Biotechnol (2015 Jul-Sep)

Bottom Line: The prevalence of microdeletions was assessed using PCR in AZFc area of Y chromosome and statistical analysis was done using the Fisher exact test and Pearson correlation.Fisher exact tests showed that there was a significant association between gr/gr mutation and BMI (p-value: 0.044).So, they may contribute to gaining weight.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, School of Basic Sciences, Golestan University, Gorgan, Iran.

ABSTRACT

Background: Microdeletions of the Y chromosome are one of the most frequent genetic causes of spermatogenic failure in infertile men. But their role in gaining weight is unclear. The present study investigated the possible association of these partial microdeletions and obesity.

Methods: In a case-control study, 180 males were selected. The prevalence of microdeletions was assessed using PCR in AZFc area of Y chromosome and statistical analysis was done using the Fisher exact test and Pearson correlation.

Results: In our study, inverse relationship was observed between body mass index and testosterone level (p-value: 0.005). Fisher exact tests showed that there was a significant association between gr/gr mutation and BMI (p-value: 0.044).

Conclusion: Our study revealed that Y chromosome microdeletions are more common in obese men. Furthermore, microdeletions such as gr/gr, which were observed in normal men, could cause decreased testosterone level. So, they may contribute to gaining weight.

No MeSH data available.


Related in: MedlinePlus

PCR by sY1191 primer. Number 3 and 5 samples have b2/b3 deletion.
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Related In: Results  -  Collection


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Figure 2: PCR by sY1191 primer. Number 3 and 5 samples have b2/b3 deletion.

Mentions: PCR was performed with eight pairs of primers for all samples (Figure 1). Samples which had a complete mirodeletion were discarded (Table 3). To find partial microdeletions, PCR was conducted with sY1191 and sY1291 primers on the rest of the samples (Figures 2 and 3).


High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men.

Biabangard Zak A, Golalipour M, Hadadchi G - Avicenna J Med Biotechnol (2015 Jul-Sep)

PCR by sY1191 primer. Number 3 and 5 samples have b2/b3 deletion.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4508339&req=5

Figure 2: PCR by sY1191 primer. Number 3 and 5 samples have b2/b3 deletion.
Mentions: PCR was performed with eight pairs of primers for all samples (Figure 1). Samples which had a complete mirodeletion were discarded (Table 3). To find partial microdeletions, PCR was conducted with sY1191 and sY1291 primers on the rest of the samples (Figures 2 and 3).

Bottom Line: The prevalence of microdeletions was assessed using PCR in AZFc area of Y chromosome and statistical analysis was done using the Fisher exact test and Pearson correlation.Fisher exact tests showed that there was a significant association between gr/gr mutation and BMI (p-value: 0.044).So, they may contribute to gaining weight.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, School of Basic Sciences, Golestan University, Gorgan, Iran.

ABSTRACT

Background: Microdeletions of the Y chromosome are one of the most frequent genetic causes of spermatogenic failure in infertile men. But their role in gaining weight is unclear. The present study investigated the possible association of these partial microdeletions and obesity.

Methods: In a case-control study, 180 males were selected. The prevalence of microdeletions was assessed using PCR in AZFc area of Y chromosome and statistical analysis was done using the Fisher exact test and Pearson correlation.

Results: In our study, inverse relationship was observed between body mass index and testosterone level (p-value: 0.005). Fisher exact tests showed that there was a significant association between gr/gr mutation and BMI (p-value: 0.044).

Conclusion: Our study revealed that Y chromosome microdeletions are more common in obese men. Furthermore, microdeletions such as gr/gr, which were observed in normal men, could cause decreased testosterone level. So, they may contribute to gaining weight.

No MeSH data available.


Related in: MedlinePlus