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Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status.

Lee TH, Jeon WS, Han KJ, Lee SY, Kim NH, Chae HB, Jang CM, Yoo KM, Park HJ, Lee MK, Park SE, Oh HG, Park CY, Lee WY, Oh KW, Park SW, Rhee EJ - Endocrinol Metab (Seoul) (2014)

Bottom Line: Of the 456 subjects, 247 (54.2%) were in the MHNO group, 66 (14.5%) were in the MHO group, 66 (14.5%) were in the MUHNO group, and 77 (16.9%) were in the MUHO group.There were no significant differences in IL-6 or MCP-1 levels among the groups, but levels of TNF-α and A-FABP were significantly higher in the MUHNO group compared to the MHNO group.High TNF-α and A-FABP levels are significantly associated with metabolically unhealthiness in nonobese Korean individuals.

View Article: PubMed Central - PubMed

Affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Background: Metabolic health is an emerging concept that is highly correlated with various metabolic complications, and adipocytokines have been causally linked to a wide range of metabolic diseases. Thus, this study compared serum adipocytokine levels according to metabolic health and obesity status.

Methods: Four hundred and fifty-six nondiabetic subjects (mean age, 40.5 years) were categorized into four groups according to metabolic health and obesity status: metabolically healthy nonobese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy nonobese (MUHNO), and metabolically unhealthy obese (MUHO). Being metabolically healthy was defined as the presence of fewer than two of the following five metabolic abnormalities: high blood pressure, high fasting blood glucose, high triglyceride, low high density lipoprotein cholesterol, and being in the highest decile of the homeostatic model assessment of insulin resistance index. Obesity status was assessed using body mass index (BMI), with obesity defined as a BMI higher than 25 kg/m². Levels of serum interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor α (TNF-α), and adipocyte fatty acid binding protein (A-FABP) were also evaluated.

Results: Of the 456 subjects, 247 (54.2%) were in the MHNO group, 66 (14.5%) were in the MHO group, 66 (14.5%) were in the MUHNO group, and 77 (16.9%) were in the MUHO group. There were no significant differences in IL-6 or MCP-1 levels among the groups, but levels of TNF-α and A-FABP were significantly higher in the MUHNO group compared to the MHNO group.

Conclusion: High TNF-α and A-FABP levels are significantly associated with metabolically unhealthiness in nonobese Korean individuals.

No MeSH data available.


Related in: MedlinePlus

Comparison of mean (A) tumor necrosis factor α (TNF-α) and (B) adipocyte fatty acid binding protein (A-FABP) levels according to four groups divided by metabolic health and obesity. MHNO, metabolically healthy nonobese; MHO, metabolically healthy obese; MUHNO, metabolically unhealthy nonobese; MUHO, metabolically unhealthy obese. a,bDifferent letters denote significant differences between the designated groups in post hoc analyses. Otherwise, groups showed no significant differences between each groups with post hoc analyses.
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Figure 2: Comparison of mean (A) tumor necrosis factor α (TNF-α) and (B) adipocyte fatty acid binding protein (A-FABP) levels according to four groups divided by metabolic health and obesity. MHNO, metabolically healthy nonobese; MHO, metabolically healthy obese; MUHNO, metabolically unhealthy nonobese; MUHO, metabolically unhealthy obese. a,bDifferent letters denote significant differences between the designated groups in post hoc analyses. Otherwise, groups showed no significant differences between each groups with post hoc analyses.

Mentions: MUHNO group had a higher proportion of males, higher average BMI and BP; and higher levels of serum fasting glucose and TG; and lower level of serum HDL-C compared with MHNO group. MUHO group had a higher proportion of males, higher BP; and higher levels of serum fasting glucose, TG, and fasting insulin compared with MHO group. Among measured adipocytokines, IL-6 and MCP-1 levels did not differ significantly among four groups. MUHNO group showed significantly higher levels of TNF-α and A-FABP than those of MHNO group (Fig. 2). Meanwhile, there was no significant difference in levels of TNF-α and A-FABP between MUHO and MHO groups.


Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status.

Lee TH, Jeon WS, Han KJ, Lee SY, Kim NH, Chae HB, Jang CM, Yoo KM, Park HJ, Lee MK, Park SE, Oh HG, Park CY, Lee WY, Oh KW, Park SW, Rhee EJ - Endocrinol Metab (Seoul) (2014)

Comparison of mean (A) tumor necrosis factor α (TNF-α) and (B) adipocyte fatty acid binding protein (A-FABP) levels according to four groups divided by metabolic health and obesity. MHNO, metabolically healthy nonobese; MHO, metabolically healthy obese; MUHNO, metabolically unhealthy nonobese; MUHO, metabolically unhealthy obese. a,bDifferent letters denote significant differences between the designated groups in post hoc analyses. Otherwise, groups showed no significant differences between each groups with post hoc analyses.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508263&req=5

Figure 2: Comparison of mean (A) tumor necrosis factor α (TNF-α) and (B) adipocyte fatty acid binding protein (A-FABP) levels according to four groups divided by metabolic health and obesity. MHNO, metabolically healthy nonobese; MHO, metabolically healthy obese; MUHNO, metabolically unhealthy nonobese; MUHO, metabolically unhealthy obese. a,bDifferent letters denote significant differences between the designated groups in post hoc analyses. Otherwise, groups showed no significant differences between each groups with post hoc analyses.
Mentions: MUHNO group had a higher proportion of males, higher average BMI and BP; and higher levels of serum fasting glucose and TG; and lower level of serum HDL-C compared with MHNO group. MUHO group had a higher proportion of males, higher BP; and higher levels of serum fasting glucose, TG, and fasting insulin compared with MHO group. Among measured adipocytokines, IL-6 and MCP-1 levels did not differ significantly among four groups. MUHNO group showed significantly higher levels of TNF-α and A-FABP than those of MHNO group (Fig. 2). Meanwhile, there was no significant difference in levels of TNF-α and A-FABP between MUHO and MHO groups.

Bottom Line: Of the 456 subjects, 247 (54.2%) were in the MHNO group, 66 (14.5%) were in the MHO group, 66 (14.5%) were in the MUHNO group, and 77 (16.9%) were in the MUHO group.There were no significant differences in IL-6 or MCP-1 levels among the groups, but levels of TNF-α and A-FABP were significantly higher in the MUHNO group compared to the MHNO group.High TNF-α and A-FABP levels are significantly associated with metabolically unhealthiness in nonobese Korean individuals.

View Article: PubMed Central - PubMed

Affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Background: Metabolic health is an emerging concept that is highly correlated with various metabolic complications, and adipocytokines have been causally linked to a wide range of metabolic diseases. Thus, this study compared serum adipocytokine levels according to metabolic health and obesity status.

Methods: Four hundred and fifty-six nondiabetic subjects (mean age, 40.5 years) were categorized into four groups according to metabolic health and obesity status: metabolically healthy nonobese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy nonobese (MUHNO), and metabolically unhealthy obese (MUHO). Being metabolically healthy was defined as the presence of fewer than two of the following five metabolic abnormalities: high blood pressure, high fasting blood glucose, high triglyceride, low high density lipoprotein cholesterol, and being in the highest decile of the homeostatic model assessment of insulin resistance index. Obesity status was assessed using body mass index (BMI), with obesity defined as a BMI higher than 25 kg/m². Levels of serum interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor α (TNF-α), and adipocyte fatty acid binding protein (A-FABP) were also evaluated.

Results: Of the 456 subjects, 247 (54.2%) were in the MHNO group, 66 (14.5%) were in the MHO group, 66 (14.5%) were in the MUHNO group, and 77 (16.9%) were in the MUHO group. There were no significant differences in IL-6 or MCP-1 levels among the groups, but levels of TNF-α and A-FABP were significantly higher in the MUHNO group compared to the MHNO group.

Conclusion: High TNF-α and A-FABP levels are significantly associated with metabolically unhealthiness in nonobese Korean individuals.

No MeSH data available.


Related in: MedlinePlus