Keratinocyte growth factor-2 intratracheal instillation significantly attenuates ventilator-induced lung injury in rats.
Bottom Line: Inflammatory cytokines (tumour necrosis factor-α, macrophage inflammatory protein 2), neutrophil and total protein levels in bronchoalveolar lavage fluid and surfactant protein mRNA expression in lung tissue were detected; the number of alveolar type II cells, lung water content and lung morphology were also evaluated.The results indicate that pre-treatment with KGF-2 showed dramatic improvement in lung oedema and inflammation compared with HVZP alone, together with increased surfactant protein mRNA and alveolar type II cells.Our results suggest that KGF-2 might be considered a promising prevention for human VILI or other acute lung injury diseases.
Affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.Show MeSH
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Mentions: After 4 hrs MV, the partial pressure of oxygen (PaO2) of rats in HVZP group was significantly lower than that in control group (P < 0.05, Fig.1A). KGF-2 pre-treatment significantly increased PaO2 compared with the HVZP groups (P < 0.05, Fig.1A). In addition, PH value was significantly lower and the partial pressure of carbon dioxide (PaCO2) was significantly higher in animals receiving high VT (P < 0.05, Fig.1B and C), but values were similar between those pre-treated with KGF-2 and PBS.
Affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.