Renal telocytes contribute to the repair of ischemically injured renal tubules.
Bottom Line: In a renal IRI model, transplantation of renal TCs was found to decrease serum creatinine and blood urea nitrogen (BUN) levels, while renal fibroblasts exerted no such effect.Our data suggest that the protective effect of TCs against IRI occurs via inflammation-independent mechanisms in vivo.TCs did not display any advantage in paracrine growth factor secretion in vitro compared with renal fibroblasts.
Affiliation: Department of Urology, Fudan University Zhongshan Hospital, Shanghai, China; Shanghai Key Lab of Organ Transplantation, Shanghai, China.Show MeSH
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Mentions: To further evaluate the renal delivery of intravenously infused TCs, we generated GFP-TCs. The FACS results revealed that ∽75.9% of the TCs were GFP-positive (Fig.2A). Frozen sections showed GFP expression in both the kidney and the lungs following the injection of GFP-TCs (Fig.2B and C). The TCs in the kidney displayed piriform/spindle/triangular cell bodies that primarily congregated around the vessel. The number of TCs in the kidney was slightly lower than in the lungs. Moreover, there were almost no TCs found in the liver, the spleen or the intestine (Fig.2D–F).
Affiliation: Department of Urology, Fudan University Zhongshan Hospital, Shanghai, China; Shanghai Key Lab of Organ Transplantation, Shanghai, China.