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Protein profiling of human lung telocytes and microvascular endothelial cells using iTRAQ quantitative proteomics.

Zheng Y, Cretoiu D, Yan G, Cretoiu SM, Popescu LM, Fang H, Wang X - J. Cell. Mol. Med. (2014)

Bottom Line: Bioinformatics analysis using Panther revealed that the 38 proteins associated with TCs represented cellular functions such as intercellular communication (via vesicle mediated transport) and structure morphogenesis, being mainly cytoskeletal proteins and oxidoreductases.In conclusion, we report here the first extensive comparison of proteins from TCs and ECs using a quantitative proteomics approach.Moreover, they might inhibit the oxidative stress and cellular ageing and may have pro-proliferative effects through the inhibition of apoptosis.

View Article: PubMed Central - PubMed

Affiliation: Fudan University Center for Clinical Bioinformatics, Zhongshan Hospital, Fudan University School of Medicine, Shanghai, China.

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Related in: MedlinePlus

STRING analysis for ECs at day 5 investigating the interactions between up-regulated proteins and depicting ECs involvement in haemostasis (A) and extracellular vesicular exosome (B). Red nodes represent up-regulated proteins involved in these processes.
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fig12: STRING analysis for ECs at day 5 investigating the interactions between up-regulated proteins and depicting ECs involvement in haemostasis (A) and extracellular vesicular exosome (B). Red nodes represent up-regulated proteins involved in these processes.


Protein profiling of human lung telocytes and microvascular endothelial cells using iTRAQ quantitative proteomics.

Zheng Y, Cretoiu D, Yan G, Cretoiu SM, Popescu LM, Fang H, Wang X - J. Cell. Mol. Med. (2014)

STRING analysis for ECs at day 5 investigating the interactions between up-regulated proteins and depicting ECs involvement in haemostasis (A) and extracellular vesicular exosome (B). Red nodes represent up-regulated proteins involved in these processes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508144&req=5

fig12: STRING analysis for ECs at day 5 investigating the interactions between up-regulated proteins and depicting ECs involvement in haemostasis (A) and extracellular vesicular exosome (B). Red nodes represent up-regulated proteins involved in these processes.
Bottom Line: Bioinformatics analysis using Panther revealed that the 38 proteins associated with TCs represented cellular functions such as intercellular communication (via vesicle mediated transport) and structure morphogenesis, being mainly cytoskeletal proteins and oxidoreductases.In conclusion, we report here the first extensive comparison of proteins from TCs and ECs using a quantitative proteomics approach.Moreover, they might inhibit the oxidative stress and cellular ageing and may have pro-proliferative effects through the inhibition of apoptosis.

View Article: PubMed Central - PubMed

Affiliation: Fudan University Center for Clinical Bioinformatics, Zhongshan Hospital, Fudan University School of Medicine, Shanghai, China.

Show MeSH
Related in: MedlinePlus