Amniotic mesenchymal stem cells display neurovascular tropism and aid in the recovery of injured peripheral nerves.
Bottom Line: AMM implantation also augmented blood perfusion and increased intraneural vascularity.Whole-mount fluorescent imaging analysis demonstrated that AMMs exhibited higher engraftment and endothelial incorporation abilities in the sciatic nerve.In addition, the higher expression of pro-angiogenic factors was detected in AMMs injected into the peripheral nerve.
Affiliation: Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.Show MeSH
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Mentions: To test the therapeutic effects of local injection of AMMs after nerve injury, we measured the MCV for 4 weeks after treatment. There were no significant differences on day 3 after the injury in all treated groups. However, on day 28, the mice treated with AMMs exhibited significantly improved recovery compared to the mice treated with the ADMs and the PBS control groups (1.02 ± 0.14 versus 0.72 ± 0.17, P = 0.021 and 0.37 ± 0.14, P = 0.003, respectively; Fig.1A).
Affiliation: Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.