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Amniotic mesenchymal stem cells display neurovascular tropism and aid in the recovery of injured peripheral nerves.

Li Y, Guo L, Ahn HS, Kim MH, Kim SW - J. Cell. Mol. Med. (2014)

Bottom Line: AMM implantation also augmented blood perfusion and increased intraneural vascularity.Whole-mount fluorescent imaging analysis demonstrated that AMMs exhibited higher engraftment and endothelial incorporation abilities in the sciatic nerve.In addition, the higher expression of pro-angiogenic factors was detected in AMMs injected into the peripheral nerve.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.

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Amniotic membrane-derived mesenchymal stem cells (AMMs) transplantation promotes functional and physiological recovery in damaged sciatic nerves. (A) Motor nerve conduction velocity (m/sec.) and (B) nerve voltage amplitude (mV) were examined for 4 weeks after nerve injury. **P < 0.05 AMMs versus PBS, †P < 0.05 AMMs versus adipose-derived mesenchymal stem cells (ADM)s, ‡P < 0.01 ADMs versus PBS, §P < 0.01 ADMs versus PBS. n = 9 per group. (C) Exercise duration was assessed at 4 weeks after nerve injury. **P < 0.01, *P < 0.05; n = 6 per group.
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fig01: Amniotic membrane-derived mesenchymal stem cells (AMMs) transplantation promotes functional and physiological recovery in damaged sciatic nerves. (A) Motor nerve conduction velocity (m/sec.) and (B) nerve voltage amplitude (mV) were examined for 4 weeks after nerve injury. **P < 0.05 AMMs versus PBS, †P < 0.05 AMMs versus adipose-derived mesenchymal stem cells (ADM)s, ‡P < 0.01 ADMs versus PBS, §P < 0.01 ADMs versus PBS. n = 9 per group. (C) Exercise duration was assessed at 4 weeks after nerve injury. **P < 0.01, *P < 0.05; n = 6 per group.

Mentions: To test the therapeutic effects of local injection of AMMs after nerve injury, we measured the MCV for 4 weeks after treatment. There were no significant differences on day 3 after the injury in all treated groups. However, on day 28, the mice treated with AMMs exhibited significantly improved recovery compared to the mice treated with the ADMs and the PBS control groups (1.02 ± 0.14 versus 0.72 ± 0.17, P = 0.021 and 0.37 ± 0.14, P = 0.003, respectively; Fig.1A).


Amniotic mesenchymal stem cells display neurovascular tropism and aid in the recovery of injured peripheral nerves.

Li Y, Guo L, Ahn HS, Kim MH, Kim SW - J. Cell. Mol. Med. (2014)

Amniotic membrane-derived mesenchymal stem cells (AMMs) transplantation promotes functional and physiological recovery in damaged sciatic nerves. (A) Motor nerve conduction velocity (m/sec.) and (B) nerve voltage amplitude (mV) were examined for 4 weeks after nerve injury. **P < 0.05 AMMs versus PBS, †P < 0.05 AMMs versus adipose-derived mesenchymal stem cells (ADM)s, ‡P < 0.01 ADMs versus PBS, §P < 0.01 ADMs versus PBS. n = 9 per group. (C) Exercise duration was assessed at 4 weeks after nerve injury. **P < 0.01, *P < 0.05; n = 6 per group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508143&req=5

fig01: Amniotic membrane-derived mesenchymal stem cells (AMMs) transplantation promotes functional and physiological recovery in damaged sciatic nerves. (A) Motor nerve conduction velocity (m/sec.) and (B) nerve voltage amplitude (mV) were examined for 4 weeks after nerve injury. **P < 0.05 AMMs versus PBS, †P < 0.05 AMMs versus adipose-derived mesenchymal stem cells (ADM)s, ‡P < 0.01 ADMs versus PBS, §P < 0.01 ADMs versus PBS. n = 9 per group. (C) Exercise duration was assessed at 4 weeks after nerve injury. **P < 0.01, *P < 0.05; n = 6 per group.
Mentions: To test the therapeutic effects of local injection of AMMs after nerve injury, we measured the MCV for 4 weeks after treatment. There were no significant differences on day 3 after the injury in all treated groups. However, on day 28, the mice treated with AMMs exhibited significantly improved recovery compared to the mice treated with the ADMs and the PBS control groups (1.02 ± 0.14 versus 0.72 ± 0.17, P = 0.021 and 0.37 ± 0.14, P = 0.003, respectively; Fig.1A).

Bottom Line: AMM implantation also augmented blood perfusion and increased intraneural vascularity.Whole-mount fluorescent imaging analysis demonstrated that AMMs exhibited higher engraftment and endothelial incorporation abilities in the sciatic nerve.In addition, the higher expression of pro-angiogenic factors was detected in AMMs injected into the peripheral nerve.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.

Show MeSH
Related in: MedlinePlus