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An Interactive Tool for Animating Biology, and Its Use in Spatial and Temporal Modeling of a Cancerous Tumor and Its Microenvironment.

Bloch N, Weiss G, Szekely S, Harel D - PLoS ONE (2015)

Bottom Line: The ability to visualize the ongoing events of a computational model of biology is critical, both in order to see the dynamics of the biological system in action and to enable interaction with the model from which one can observe the resulting behavior.To this end, we have built a new interactive animation tool, SimuLife, for visualizing reactive models of cellular biology.This has helped in understanding the dynamics of the tumor and its surrounding blood vessels, and in verifying the behavior, fine-tuning the model accordingly, and learning in which way different factors affect the tumor.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.

ABSTRACT
The ability to visualize the ongoing events of a computational model of biology is critical, both in order to see the dynamics of the biological system in action and to enable interaction with the model from which one can observe the resulting behavior. To this end, we have built a new interactive animation tool, SimuLife, for visualizing reactive models of cellular biology. SimuLife is web-based, and is freely accessible at http://simulife.weizmann.ac.il/. We have used SimuLife to animate a model that describes the development of a cancerous tumor, based on the individual components of the system and its environment. This has helped in understanding the dynamics of the tumor and its surrounding blood vessels, and in verifying the behavior, fine-tuning the model accordingly, and learning in which way different factors affect the tumor.

No MeSH data available.


Related in: MedlinePlus

SimuLife images, presenting different capabilities.(a) Can use more realistic images (left) or simple spherical images (right). (b) Default colors (left) or a possible change of colors (right). (c) Make certain objects invisible in order to focus on other ones. Left – blood vessels, center – tumor, right – molecules. (d) Slicing: a 2D cross section (in this case of a tumor, showing the inside core).
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pone.0133484.g002: SimuLife images, presenting different capabilities.(a) Can use more realistic images (left) or simple spherical images (right). (b) Default colors (left) or a possible change of colors (right). (c) Make certain objects invisible in order to focus on other ones. Left – blood vessels, center – tumor, right – molecules. (d) Slicing: a 2D cross section (in this case of a tumor, showing the inside core).

Mentions: Represent cells using either simple spherical images or more realistic-looking ones (the latter is more costly computationally and can affect the performance) (Fig 2A).


An Interactive Tool for Animating Biology, and Its Use in Spatial and Temporal Modeling of a Cancerous Tumor and Its Microenvironment.

Bloch N, Weiss G, Szekely S, Harel D - PLoS ONE (2015)

SimuLife images, presenting different capabilities.(a) Can use more realistic images (left) or simple spherical images (right). (b) Default colors (left) or a possible change of colors (right). (c) Make certain objects invisible in order to focus on other ones. Left – blood vessels, center – tumor, right – molecules. (d) Slicing: a 2D cross section (in this case of a tumor, showing the inside core).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508114&req=5

pone.0133484.g002: SimuLife images, presenting different capabilities.(a) Can use more realistic images (left) or simple spherical images (right). (b) Default colors (left) or a possible change of colors (right). (c) Make certain objects invisible in order to focus on other ones. Left – blood vessels, center – tumor, right – molecules. (d) Slicing: a 2D cross section (in this case of a tumor, showing the inside core).
Mentions: Represent cells using either simple spherical images or more realistic-looking ones (the latter is more costly computationally and can affect the performance) (Fig 2A).

Bottom Line: The ability to visualize the ongoing events of a computational model of biology is critical, both in order to see the dynamics of the biological system in action and to enable interaction with the model from which one can observe the resulting behavior.To this end, we have built a new interactive animation tool, SimuLife, for visualizing reactive models of cellular biology.This has helped in understanding the dynamics of the tumor and its surrounding blood vessels, and in verifying the behavior, fine-tuning the model accordingly, and learning in which way different factors affect the tumor.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.

ABSTRACT
The ability to visualize the ongoing events of a computational model of biology is critical, both in order to see the dynamics of the biological system in action and to enable interaction with the model from which one can observe the resulting behavior. To this end, we have built a new interactive animation tool, SimuLife, for visualizing reactive models of cellular biology. SimuLife is web-based, and is freely accessible at http://simulife.weizmann.ac.il/. We have used SimuLife to animate a model that describes the development of a cancerous tumor, based on the individual components of the system and its environment. This has helped in understanding the dynamics of the tumor and its surrounding blood vessels, and in verifying the behavior, fine-tuning the model accordingly, and learning in which way different factors affect the tumor.

No MeSH data available.


Related in: MedlinePlus