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Prevalence of comorbid retinal disease in patients with glaucoma at an academic medical center.

Griffith JF, Goldberg JL - Clin Ophthalmol (2015)

Bottom Line: Patients with comorbid retinal disease had a higher prevalence of blindness and low vision than those without comorbid retinal disease (1.97% versus 1.02%, P=0.02).The high prevalence of comorbid retinal disease and the nearly twofold increase in blindness and low vision in this population demonstrate the need for ophthalmologists to determine if patients have multiple etiologies for their vision loss.The higher prevalence of certain retinal diseases in POAG patients may reflect common pathophysiological processes that warrant further investigation.

View Article: PubMed Central - PubMed

Affiliation: Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

ABSTRACT

Background: Patients with various retinal diseases and patients who have undergone retinal procedures and surgeries have an increased risk of developing ocular hypertension and glaucoma. Little is known about the epidemiology of comorbid retinal diseases in glaucoma patients. This study evaluated the prevalence of retinal comorbidities in a population of patients with five types of glaucoma.

Methods: A longitudinal, retrospective study was conducted using International Classification of Disease (ICD-9) billing records from 2003 to 2010 at an academic medical center. Patients were classified as having primary open-angle glaucoma (POAG), low tension open-angle glaucoma (NTG), pigmentary open-angle glaucoma, chronic-angle closure glaucoma (CACG), or pseudoexfoliation glaucoma (PXG) if they had at least three clinic visits with the same ICD-9 code. Patients were classified as having a retinal comorbidity if they had two visits with the same code. Variables were analyzed with the independent t-test, χ (2) test, analysis of variance, or Fisher's exact test.

Results: A total of 5,154 patients had glaucoma, and 14.8% of these had a retinal comorbidity. The prevalence of comorbid retinal disease was higher in patients with POAG (15.7%) than in those with NTG (10.7%), PXG (10.1%), or pigmentary open-angle glaucoma (3.7%; P<0.05). Two hundred and two patients had diabetic retinopathy, with POAG patients (4.5%) having a higher prevalence than those with CACG (1.4%) or PXG (0.6%; P<0.001). There were 297 patients who had macular degeneration and both POAG (2.0%) and PXG patients (2.9%) had a higher prevalence of nonexudative macular degeneration than those with CACG (0%; P<0.01). Patients with comorbid retinal disease had a higher prevalence of blindness and low vision than those without comorbid retinal disease (1.97% versus 1.02%, P=0.02).

Conclusion: The high prevalence of comorbid retinal disease and the nearly twofold increase in blindness and low vision in this population demonstrate the need for ophthalmologists to determine if patients have multiple etiologies for their vision loss. The higher prevalence of certain retinal diseases in POAG patients may reflect common pathophysiological processes that warrant further investigation.

No MeSH data available.


Related in: MedlinePlus

Prevalence of comorbid retinal disease by glaucoma type. POAG patients (15.7%) had a higher prevalence of comorbid retinal disease than NTG (10.7%), PXG (10.1%), and PG (3.7%) patients.Note:P<0.05, χ2 test.Abbreviations: POAG, primary open-angle glaucoma; NTG, low tension open-angle glaucoma; PG, pigmentary open-angle glaucoma; CACG, chronic angle-closure glaucoma; PXG, pseudoexfoliation glaucoma.
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f1-opth-9-1275: Prevalence of comorbid retinal disease by glaucoma type. POAG patients (15.7%) had a higher prevalence of comorbid retinal disease than NTG (10.7%), PXG (10.1%), and PG (3.7%) patients.Note:P<0.05, χ2 test.Abbreviations: POAG, primary open-angle glaucoma; NTG, low tension open-angle glaucoma; PG, pigmentary open-angle glaucoma; CACG, chronic angle-closure glaucoma; PXG, pseudoexfoliation glaucoma.

Mentions: We next asked what types of glaucoma patients are most likely to have comorbid retinal disease. Table 2 and Figure 1 list the proportions of patients with comorbid retinal disease by glaucoma type. There was a larger proportion of POAG patients with comorbid retinal disease (15.7%) than NTG patients (10.7%, P=0.014, χ2 test), PXG patients (10.1%, P=0.008, χ2 test), and pigmentary open-angle glaucoma patients (3.7%, P=0.013, Fisher’s exact test). There were no other differences in the proportions of comorbid retinal disease between type of glaucoma patients (P>0.05, χ2 test and Fisher’s exact test).


Prevalence of comorbid retinal disease in patients with glaucoma at an academic medical center.

Griffith JF, Goldberg JL - Clin Ophthalmol (2015)

Prevalence of comorbid retinal disease by glaucoma type. POAG patients (15.7%) had a higher prevalence of comorbid retinal disease than NTG (10.7%), PXG (10.1%), and PG (3.7%) patients.Note:P<0.05, χ2 test.Abbreviations: POAG, primary open-angle glaucoma; NTG, low tension open-angle glaucoma; PG, pigmentary open-angle glaucoma; CACG, chronic angle-closure glaucoma; PXG, pseudoexfoliation glaucoma.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508087&req=5

f1-opth-9-1275: Prevalence of comorbid retinal disease by glaucoma type. POAG patients (15.7%) had a higher prevalence of comorbid retinal disease than NTG (10.7%), PXG (10.1%), and PG (3.7%) patients.Note:P<0.05, χ2 test.Abbreviations: POAG, primary open-angle glaucoma; NTG, low tension open-angle glaucoma; PG, pigmentary open-angle glaucoma; CACG, chronic angle-closure glaucoma; PXG, pseudoexfoliation glaucoma.
Mentions: We next asked what types of glaucoma patients are most likely to have comorbid retinal disease. Table 2 and Figure 1 list the proportions of patients with comorbid retinal disease by glaucoma type. There was a larger proportion of POAG patients with comorbid retinal disease (15.7%) than NTG patients (10.7%, P=0.014, χ2 test), PXG patients (10.1%, P=0.008, χ2 test), and pigmentary open-angle glaucoma patients (3.7%, P=0.013, Fisher’s exact test). There were no other differences in the proportions of comorbid retinal disease between type of glaucoma patients (P>0.05, χ2 test and Fisher’s exact test).

Bottom Line: Patients with comorbid retinal disease had a higher prevalence of blindness and low vision than those without comorbid retinal disease (1.97% versus 1.02%, P=0.02).The high prevalence of comorbid retinal disease and the nearly twofold increase in blindness and low vision in this population demonstrate the need for ophthalmologists to determine if patients have multiple etiologies for their vision loss.The higher prevalence of certain retinal diseases in POAG patients may reflect common pathophysiological processes that warrant further investigation.

View Article: PubMed Central - PubMed

Affiliation: Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

ABSTRACT

Background: Patients with various retinal diseases and patients who have undergone retinal procedures and surgeries have an increased risk of developing ocular hypertension and glaucoma. Little is known about the epidemiology of comorbid retinal diseases in glaucoma patients. This study evaluated the prevalence of retinal comorbidities in a population of patients with five types of glaucoma.

Methods: A longitudinal, retrospective study was conducted using International Classification of Disease (ICD-9) billing records from 2003 to 2010 at an academic medical center. Patients were classified as having primary open-angle glaucoma (POAG), low tension open-angle glaucoma (NTG), pigmentary open-angle glaucoma, chronic-angle closure glaucoma (CACG), or pseudoexfoliation glaucoma (PXG) if they had at least three clinic visits with the same ICD-9 code. Patients were classified as having a retinal comorbidity if they had two visits with the same code. Variables were analyzed with the independent t-test, χ (2) test, analysis of variance, or Fisher's exact test.

Results: A total of 5,154 patients had glaucoma, and 14.8% of these had a retinal comorbidity. The prevalence of comorbid retinal disease was higher in patients with POAG (15.7%) than in those with NTG (10.7%), PXG (10.1%), or pigmentary open-angle glaucoma (3.7%; P<0.05). Two hundred and two patients had diabetic retinopathy, with POAG patients (4.5%) having a higher prevalence than those with CACG (1.4%) or PXG (0.6%; P<0.001). There were 297 patients who had macular degeneration and both POAG (2.0%) and PXG patients (2.9%) had a higher prevalence of nonexudative macular degeneration than those with CACG (0%; P<0.01). Patients with comorbid retinal disease had a higher prevalence of blindness and low vision than those without comorbid retinal disease (1.97% versus 1.02%, P=0.02).

Conclusion: The high prevalence of comorbid retinal disease and the nearly twofold increase in blindness and low vision in this population demonstrate the need for ophthalmologists to determine if patients have multiple etiologies for their vision loss. The higher prevalence of certain retinal diseases in POAG patients may reflect common pathophysiological processes that warrant further investigation.

No MeSH data available.


Related in: MedlinePlus