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The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer.

Zhao D, Guo L, Neves H, Yuen HF, Zhang SD, McCrudden CM, Wen Q, Zhang J, Zeng Q, Kwok HF, Lin Y - Onco Targets Ther (2015)

Bottom Line: Although PTP4A3 has been shown to be a very important factor in promoting cancer progression, the role of its close family member PTP4A2 is still largely unknown.Low PTP4A2 expression was associated with estrogen receptor-negative tumors and tumors with higher histological grading; furthermore, low expression was inversely correlated with the expression of genes involved in proliferation, including MKI67 and the MCM gene family encoding the minichromosome maintenance proteins.PTP4A2 expression was positively correlated with ESR1, the gene encoding estrogen receptor-alpha, and inversely correlated with EGFR expression, suggesting that PTP4A2 may be involved in these two important oncogenic pathways.

View Article: PubMed Central - PubMed

Affiliation: College of Continuing Education, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu, People's Republic of China.

ABSTRACT
Although PTP4A3 has been shown to be a very important factor in promoting cancer progression, the role of its close family member PTP4A2 is still largely unknown. Recent reports have shown contradicting results on the role of PTP4A2 in breast cancer progression. Considering this, we aimed to investigate the prognostic value of PTP4A2 in five independent breast cancer data sets (minimum 198 patients per cohort, totaling 1,124 patients) in the Gene Expression Omnibus Database. We found that high expression of PTP4A2 was a favorable prognostic marker in all five independent breast cancer data sets, as well as in the combined cohort, with a hazard ratio of 0.68 (95% confidence interval =0.56-0.83; P<0.001). Low PTP4A2 expression was associated with estrogen receptor-negative tumors and tumors with higher histological grading; furthermore, low expression was inversely correlated with the expression of genes involved in proliferation, including MKI67 and the MCM gene family encoding the minichromosome maintenance proteins. These findings suggest that PTP4A2 may play a role in breast cancer progression by dysregulating cell proliferation. PTP4A2 expression was positively correlated with ESR1, the gene encoding estrogen receptor-alpha, and inversely correlated with EGFR expression, suggesting that PTP4A2 may be involved in these two important oncogenic pathways. Together, our results suggest that expression of PTP4A2 is a favorable prognostic marker in breast cancer.

No MeSH data available.


Related in: MedlinePlus

The association between PTP4A2 expression and histological grading.Notes: Box plots of PTP4A2 expression in tumors with different histological grades in (A) GSE3494, (B) GSE7390, and (C) GSE11121 breast cancer data sets.Abbreviation:PTP4A2, protein tyrosine phosphatase 4A2.
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f3-ott-8-1707: The association between PTP4A2 expression and histological grading.Notes: Box plots of PTP4A2 expression in tumors with different histological grades in (A) GSE3494, (B) GSE7390, and (C) GSE11121 breast cancer data sets.Abbreviation:PTP4A2, protein tyrosine phosphatase 4A2.

Mentions: Histological grade is another important prognostic factor in breast cancer.22 Here, we also investigated the association between the expression level of PTP4A2 and the histological grading of the tumors in the three cohorts for which tumor grade had been documented. As shown in Figure 3, PTP4A2 expression was significantly lower in grade 3 tumors compared to those tumors with lower grading in GSE3494 (P=0.012; Figure 3A), GSE7390 (P<0.001; Figure 3B), and GSE11121 (P=0.009; Figure 3C), all the three breast cancer data sets with histological grading available in GEO database. The results suggest that PTP4A2 expression is downregulated in breast tumor with increasing histological grading.


The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer.

Zhao D, Guo L, Neves H, Yuen HF, Zhang SD, McCrudden CM, Wen Q, Zhang J, Zeng Q, Kwok HF, Lin Y - Onco Targets Ther (2015)

The association between PTP4A2 expression and histological grading.Notes: Box plots of PTP4A2 expression in tumors with different histological grades in (A) GSE3494, (B) GSE7390, and (C) GSE11121 breast cancer data sets.Abbreviation:PTP4A2, protein tyrosine phosphatase 4A2.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508076&req=5

f3-ott-8-1707: The association between PTP4A2 expression and histological grading.Notes: Box plots of PTP4A2 expression in tumors with different histological grades in (A) GSE3494, (B) GSE7390, and (C) GSE11121 breast cancer data sets.Abbreviation:PTP4A2, protein tyrosine phosphatase 4A2.
Mentions: Histological grade is another important prognostic factor in breast cancer.22 Here, we also investigated the association between the expression level of PTP4A2 and the histological grading of the tumors in the three cohorts for which tumor grade had been documented. As shown in Figure 3, PTP4A2 expression was significantly lower in grade 3 tumors compared to those tumors with lower grading in GSE3494 (P=0.012; Figure 3A), GSE7390 (P<0.001; Figure 3B), and GSE11121 (P=0.009; Figure 3C), all the three breast cancer data sets with histological grading available in GEO database. The results suggest that PTP4A2 expression is downregulated in breast tumor with increasing histological grading.

Bottom Line: Although PTP4A3 has been shown to be a very important factor in promoting cancer progression, the role of its close family member PTP4A2 is still largely unknown.Low PTP4A2 expression was associated with estrogen receptor-negative tumors and tumors with higher histological grading; furthermore, low expression was inversely correlated with the expression of genes involved in proliferation, including MKI67 and the MCM gene family encoding the minichromosome maintenance proteins.PTP4A2 expression was positively correlated with ESR1, the gene encoding estrogen receptor-alpha, and inversely correlated with EGFR expression, suggesting that PTP4A2 may be involved in these two important oncogenic pathways.

View Article: PubMed Central - PubMed

Affiliation: College of Continuing Education, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu, People's Republic of China.

ABSTRACT
Although PTP4A3 has been shown to be a very important factor in promoting cancer progression, the role of its close family member PTP4A2 is still largely unknown. Recent reports have shown contradicting results on the role of PTP4A2 in breast cancer progression. Considering this, we aimed to investigate the prognostic value of PTP4A2 in five independent breast cancer data sets (minimum 198 patients per cohort, totaling 1,124 patients) in the Gene Expression Omnibus Database. We found that high expression of PTP4A2 was a favorable prognostic marker in all five independent breast cancer data sets, as well as in the combined cohort, with a hazard ratio of 0.68 (95% confidence interval =0.56-0.83; P<0.001). Low PTP4A2 expression was associated with estrogen receptor-negative tumors and tumors with higher histological grading; furthermore, low expression was inversely correlated with the expression of genes involved in proliferation, including MKI67 and the MCM gene family encoding the minichromosome maintenance proteins. These findings suggest that PTP4A2 may play a role in breast cancer progression by dysregulating cell proliferation. PTP4A2 expression was positively correlated with ESR1, the gene encoding estrogen receptor-alpha, and inversely correlated with EGFR expression, suggesting that PTP4A2 may be involved in these two important oncogenic pathways. Together, our results suggest that expression of PTP4A2 is a favorable prognostic marker in breast cancer.

No MeSH data available.


Related in: MedlinePlus