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Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial.

van Poppel PC, Breedveld P, Abbink EJ, Roelofs H, van Heerde W, Smits P, Lin W, Tan AH, Russel FG, Donders R, Tack CJ, Rongen GA - PLoS ONE (2015)

Bottom Line: LDL cholesterol levels were 3.82±0.14 mmol/l after Danshen and 3.52±0.16 mmol/l after placebo treatment (mean±SE; p<0.05 for treatment effect corrected for baseline).Danshen treatment had no effect on blood pressure (ABPM 138/84 after Danshen and 136/87 after placebo treatment).These results were further substantiated by the observation that Danshen had neither an effect on endothelial function nor on markers of inflammation, oxidative stress, glucose metabolism, hemostasis and blood viscosity.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Radboud university medical center, Nijmegen, The Netherlands.

ABSTRACT

Purpose: Danshen is the dried root extract of the plant Salvia Miltiorrhiza and it is used as traditional Chinese medicinal herbal product to prevent and treat atherosclerosis. However, its efficacy has not been thoroughly investigated. This study evaluates the effect of Danshen on hyperlipidemia and hypertension, two well known risk factors for the development of atherosclerosis.

Methods: This was a randomized, placebo-controlled, double-blind crossover study performed at a tertiary referral center. Participants were recruited by newspaper advertisement and randomized to treatment with Danshen (water-extract of the Salvia Miltiorrhiza root) or placebo for 4 consecutive weeks. There was a wash out period of 4 weeks. Of the 20 analysed participants, 11 received placebo first. Inclusion criteria were: age 40-70 years, hyperlipidemia and hypertension. At the end of each treatment period, plasma lipids were determined (primary outcome), 24 hours ambulant blood pressure measurement (ABPM) was performed, and vasodilator endothelial function was assessed in the forearm.

Results: LDL cholesterol levels were 3.82±0.14 mmol/l after Danshen and 3.52±0.16 mmol/l after placebo treatment (mean±SE; p<0.05 for treatment effect corrected for baseline). Danshen treatment had no effect on blood pressure (ABPM 138/84 after Danshen and 136/87 after placebo treatment). These results were further substantiated by the observation that Danshen had neither an effect on endothelial function nor on markers of inflammation, oxidative stress, glucose metabolism, hemostasis and blood viscosity.

Conclusion: Four weeks of treatment with Danshen (water-extract) slightly increased LDL-cholesterol without affecting a wide variety of other risk markers. These observations do not support the use of Danshen to prevent or treat atherosclerosis.

Trial registration: ClinicalTrials.gov NCT01563770.

No MeSH data available.


Related in: MedlinePlus

Assessment of endothelial function.Forearm blood flow in response to acetylcholine in the experimental arm (solid lines) and in the non experimental arm (dashed lines) in response to acetylcholine (left panel; dosage 0.5, 2.0, 8.0 μg.dl-1.min-1) and sodium nitroprusside (right panel; dosage 0.06, 0.20 and 0.60 μg.dl-1.min-1), during Danshen (dark grey circles) or placebo (light grey squares).
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pone.0128695.g003: Assessment of endothelial function.Forearm blood flow in response to acetylcholine in the experimental arm (solid lines) and in the non experimental arm (dashed lines) in response to acetylcholine (left panel; dosage 0.5, 2.0, 8.0 μg.dl-1.min-1) and sodium nitroprusside (right panel; dosage 0.06, 0.20 and 0.60 μg.dl-1.min-1), during Danshen (dark grey circles) or placebo (light grey squares).

Mentions: Infusion of acetylcholine induced a dose-dependent increase in FBF in the experimental forearm while FBF did not change in the non-experimental forearm. Danshen treatment did not alter the FBF in response to acetylcholine compared to placebo. With Danshen, FBF increased from 2.3±0.2 ml.dl-1.min-1 during saline to 7.5±0.8, 12.1±1.0 and 16.3±1.3 ml.dl-1.min-1 during acetylcholine 0.5, 2.0 and 8.0 μg.dl-1.min-1 respectively compared to 2.6±0.4 during saline and 8.2±0.9, 12.6± 1.1 and 16.6± 1.3 ml.dl-1.min-1 during acetylcholine with placebo (Fig 3). Comparable results were obtained when data were expressed as absolute and relative changes in FBF from baseline.


Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial.

van Poppel PC, Breedveld P, Abbink EJ, Roelofs H, van Heerde W, Smits P, Lin W, Tan AH, Russel FG, Donders R, Tack CJ, Rongen GA - PLoS ONE (2015)

Assessment of endothelial function.Forearm blood flow in response to acetylcholine in the experimental arm (solid lines) and in the non experimental arm (dashed lines) in response to acetylcholine (left panel; dosage 0.5, 2.0, 8.0 μg.dl-1.min-1) and sodium nitroprusside (right panel; dosage 0.06, 0.20 and 0.60 μg.dl-1.min-1), during Danshen (dark grey circles) or placebo (light grey squares).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4508048&req=5

pone.0128695.g003: Assessment of endothelial function.Forearm blood flow in response to acetylcholine in the experimental arm (solid lines) and in the non experimental arm (dashed lines) in response to acetylcholine (left panel; dosage 0.5, 2.0, 8.0 μg.dl-1.min-1) and sodium nitroprusside (right panel; dosage 0.06, 0.20 and 0.60 μg.dl-1.min-1), during Danshen (dark grey circles) or placebo (light grey squares).
Mentions: Infusion of acetylcholine induced a dose-dependent increase in FBF in the experimental forearm while FBF did not change in the non-experimental forearm. Danshen treatment did not alter the FBF in response to acetylcholine compared to placebo. With Danshen, FBF increased from 2.3±0.2 ml.dl-1.min-1 during saline to 7.5±0.8, 12.1±1.0 and 16.3±1.3 ml.dl-1.min-1 during acetylcholine 0.5, 2.0 and 8.0 μg.dl-1.min-1 respectively compared to 2.6±0.4 during saline and 8.2±0.9, 12.6± 1.1 and 16.6± 1.3 ml.dl-1.min-1 during acetylcholine with placebo (Fig 3). Comparable results were obtained when data were expressed as absolute and relative changes in FBF from baseline.

Bottom Line: LDL cholesterol levels were 3.82±0.14 mmol/l after Danshen and 3.52±0.16 mmol/l after placebo treatment (mean±SE; p<0.05 for treatment effect corrected for baseline).Danshen treatment had no effect on blood pressure (ABPM 138/84 after Danshen and 136/87 after placebo treatment).These results were further substantiated by the observation that Danshen had neither an effect on endothelial function nor on markers of inflammation, oxidative stress, glucose metabolism, hemostasis and blood viscosity.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Radboud university medical center, Nijmegen, The Netherlands.

ABSTRACT

Purpose: Danshen is the dried root extract of the plant Salvia Miltiorrhiza and it is used as traditional Chinese medicinal herbal product to prevent and treat atherosclerosis. However, its efficacy has not been thoroughly investigated. This study evaluates the effect of Danshen on hyperlipidemia and hypertension, two well known risk factors for the development of atherosclerosis.

Methods: This was a randomized, placebo-controlled, double-blind crossover study performed at a tertiary referral center. Participants were recruited by newspaper advertisement and randomized to treatment with Danshen (water-extract of the Salvia Miltiorrhiza root) or placebo for 4 consecutive weeks. There was a wash out period of 4 weeks. Of the 20 analysed participants, 11 received placebo first. Inclusion criteria were: age 40-70 years, hyperlipidemia and hypertension. At the end of each treatment period, plasma lipids were determined (primary outcome), 24 hours ambulant blood pressure measurement (ABPM) was performed, and vasodilator endothelial function was assessed in the forearm.

Results: LDL cholesterol levels were 3.82±0.14 mmol/l after Danshen and 3.52±0.16 mmol/l after placebo treatment (mean±SE; p<0.05 for treatment effect corrected for baseline). Danshen treatment had no effect on blood pressure (ABPM 138/84 after Danshen and 136/87 after placebo treatment). These results were further substantiated by the observation that Danshen had neither an effect on endothelial function nor on markers of inflammation, oxidative stress, glucose metabolism, hemostasis and blood viscosity.

Conclusion: Four weeks of treatment with Danshen (water-extract) slightly increased LDL-cholesterol without affecting a wide variety of other risk markers. These observations do not support the use of Danshen to prevent or treat atherosclerosis.

Trial registration: ClinicalTrials.gov NCT01563770.

No MeSH data available.


Related in: MedlinePlus