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Maternal Caffeine Consumption during Pregnancy and Risk of Low Birth Weight: A Dose-Response Meta-Analysis of Observational Studies.

Rhee J, Kim R, Kim Y, Tam M, Lai Y, Keum N, Oldenburg CE - PLoS ONE (2015)

Bottom Line: Epidemiologic studies have shown inconsistent conclusions about the effect of caffeine intake during pregnancy on the risk of low birth weight (LBW).Using a random-effects model of the twelve studies, the pooled odds ratio (OR) for the risk of LBW comparing the highest versus lowest level of caffeine intake during pregnancy was 1.38 (95% CI: 1.10, 1.73).Thus, high caffeine intake during pregnancy is associated with a significant increase in the risk of LBW, and this risk appears to increase linearly as caffeine intake increases.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

ABSTRACT
Epidemiologic studies have shown inconsistent conclusions about the effect of caffeine intake during pregnancy on the risk of low birth weight (LBW). We performed a meta-analysis and linear-dose response analysis examining the association between caffeine consumption during pregnancy and risk of LBW. PubMed and EMBASE were searched for relevant articles published up to March 2014. Eight cohort and four case-control studies met all inclusion criteria. Using a random-effects model of the twelve studies, the pooled odds ratio (OR) for the risk of LBW comparing the highest versus lowest level of caffeine intake during pregnancy was 1.38 (95% CI: 1.10, 1.73). Linear dose-response analysis showed that every additional 100 mg of caffeine intake (1 cup of coffee or 2 cups of tea) per day during pregnancy was associated with a 3.0% increase in OR for LBW. There was a moderate level of overall heterogeneity with an I-squared value of 55% (95% CI: 13, 76%), and no evidence of publication bias based on Egger's test (P = 0.20) and the funnel plot. Thus, high caffeine intake during pregnancy is associated with a significant increase in the risk of LBW, and this risk appears to increase linearly as caffeine intake increases.

No MeSH data available.


Related in: MedlinePlus

Forest plot of meta-analysis by using random effects model for the effect of maternal caffeine intake during pregnancy on the risk of low birth weight (comparing highest versus lowest levels) among cohort studies.
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pone.0132334.g003: Forest plot of meta-analysis by using random effects model for the effect of maternal caffeine intake during pregnancy on the risk of low birth weight (comparing highest versus lowest levels) among cohort studies.

Mentions: Firstly, meta-analysis for highest vs lowest exposure was performed. The summary ORs and 95% CIs were calculated by using random effects model, which allows for between-study variation. If consumption was reported as cups/day, we used a conversion equation of 100mg/day of caffeine for 1 cup of coffee and 50mg/day for 1 cup of tea [16]. The forest plot of the overall highest vs lowest meta-analysis is presented (Fig 2 and S3 Table) as well as the plots of subgroup analysis by cohort and case-control study designs (Figs 3 and 4). Every point in the forest plots (Figs 2, 3 and 4) is each study’s odds ratio of LBW comparing highest versus lowest maternal caffeine consumption.


Maternal Caffeine Consumption during Pregnancy and Risk of Low Birth Weight: A Dose-Response Meta-Analysis of Observational Studies.

Rhee J, Kim R, Kim Y, Tam M, Lai Y, Keum N, Oldenburg CE - PLoS ONE (2015)

Forest plot of meta-analysis by using random effects model for the effect of maternal caffeine intake during pregnancy on the risk of low birth weight (comparing highest versus lowest levels) among cohort studies.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507998&req=5

pone.0132334.g003: Forest plot of meta-analysis by using random effects model for the effect of maternal caffeine intake during pregnancy on the risk of low birth weight (comparing highest versus lowest levels) among cohort studies.
Mentions: Firstly, meta-analysis for highest vs lowest exposure was performed. The summary ORs and 95% CIs were calculated by using random effects model, which allows for between-study variation. If consumption was reported as cups/day, we used a conversion equation of 100mg/day of caffeine for 1 cup of coffee and 50mg/day for 1 cup of tea [16]. The forest plot of the overall highest vs lowest meta-analysis is presented (Fig 2 and S3 Table) as well as the plots of subgroup analysis by cohort and case-control study designs (Figs 3 and 4). Every point in the forest plots (Figs 2, 3 and 4) is each study’s odds ratio of LBW comparing highest versus lowest maternal caffeine consumption.

Bottom Line: Epidemiologic studies have shown inconsistent conclusions about the effect of caffeine intake during pregnancy on the risk of low birth weight (LBW).Using a random-effects model of the twelve studies, the pooled odds ratio (OR) for the risk of LBW comparing the highest versus lowest level of caffeine intake during pregnancy was 1.38 (95% CI: 1.10, 1.73).Thus, high caffeine intake during pregnancy is associated with a significant increase in the risk of LBW, and this risk appears to increase linearly as caffeine intake increases.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

ABSTRACT
Epidemiologic studies have shown inconsistent conclusions about the effect of caffeine intake during pregnancy on the risk of low birth weight (LBW). We performed a meta-analysis and linear-dose response analysis examining the association between caffeine consumption during pregnancy and risk of LBW. PubMed and EMBASE were searched for relevant articles published up to March 2014. Eight cohort and four case-control studies met all inclusion criteria. Using a random-effects model of the twelve studies, the pooled odds ratio (OR) for the risk of LBW comparing the highest versus lowest level of caffeine intake during pregnancy was 1.38 (95% CI: 1.10, 1.73). Linear dose-response analysis showed that every additional 100 mg of caffeine intake (1 cup of coffee or 2 cups of tea) per day during pregnancy was associated with a 3.0% increase in OR for LBW. There was a moderate level of overall heterogeneity with an I-squared value of 55% (95% CI: 13, 76%), and no evidence of publication bias based on Egger's test (P = 0.20) and the funnel plot. Thus, high caffeine intake during pregnancy is associated with a significant increase in the risk of LBW, and this risk appears to increase linearly as caffeine intake increases.

No MeSH data available.


Related in: MedlinePlus