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Geographic Variation in Cancer Incidence among Children and Adolescents in Taiwan (1995-2009).

Hung GY, Horng JL, Yen HJ, Lee CY, Lee YS - PLoS ONE (2015)

Bottom Line: Trend analysis showed that the most significant increase in incidence rate was observed at the township level, with an annual percent change of 1.8% during the 15-year study period.The high rate of childhood cancer in Northern Taiwan and at the township level deserves further attention.The potential impacts of environmental factors on the upward trend of childhood cancer incidence rate in townships warrant further investigation.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Hematology and Oncology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Pediatrics, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.

ABSTRACT

Background: Evidence from our recent study suggested that the overall trend for cancer incidence in children and adolescents has been increasing in Taiwan.

Methods: To analyze geographic variations in this trend, cancer frequencies and incidence rates of disease groups were quantified according to geographic areas among 12,633 patients aged <20 years during 1995-2009 by using the population-based Taiwan Cancer Registry. Three geographic levels were defined, namely county or city, region (Northern, Central, Southern, and Eastern Taiwan), and local administrative area (special municipality, provincial city, county-administered city, township, and aboriginal area).

Results: Of the regions, Northern Taiwan had the highest incidence rate at 139.6 per million person-years, followed by Central (132.8), Southern (131.8), and Eastern (128.4) Taiwan. Significantly higher standardized rate ratios (SRRs) were observed in Northern Taiwan (SRR = 1.06, 95% confidence interval [CI] = 1.02-1.10) and at the township level (SRR = 1.07, 95% CI = 1.03-1.11). Of the cities or counties, New Taipei City yielded the highest SRR (1.08), followed by Taipei City (SRR = 1.07). A comparison of the rates in the four regions and the remainder of Taiwan according to cancer type revealed that only the rate of neuroblastomas in Eastern Taiwan was significantly low. Trend analysis showed that the most significant increase in incidence rate was observed at the township level, with an annual percent change of 1.8% during the 15-year study period.

Conclusions: The high rate of childhood cancer in Northern Taiwan and at the township level deserves further attention. The potential impacts of environmental factors on the upward trend of childhood cancer incidence rate in townships warrant further investigation.

No MeSH data available.


Related in: MedlinePlus

Temporal trends in age-standardized incidence rates of cancer in the patients aged 0–19 years in certain geographic areas (Northern, Central, and Southern Taiwan and in townships) in Taiwan (1995–2009).APC indicates annual percent change. * Statistical significance at the 0.05 level.
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pone.0133051.g002: Temporal trends in age-standardized incidence rates of cancer in the patients aged 0–19 years in certain geographic areas (Northern, Central, and Southern Taiwan and in townships) in Taiwan (1995–2009).APC indicates annual percent change. * Statistical significance at the 0.05 level.

Mentions: Fig 2 and Table 3 show the APCs in ASRs according to geographic factors. During the 15-year study period, the ASRs rose significantly in Southern (APC = 1.7%, 95% CI = 0.7–2.6) and Central Taiwan (APC = 1.3%, 95% CI = 0.2–2.4); however, the changes were nonsignificant in Northern and Eastern Taiwan. Regarding local administrative areas, significantly increasing trends were found in townships (APC = 1.8%, 95% CI = 0.8–2.7), and special municipalities (APC = 1.6%, 95% CI = 0.2–3.0). The variations in ASRs were nonsignificant in provincial cities, county-administered cities and aboriginal areas.


Geographic Variation in Cancer Incidence among Children and Adolescents in Taiwan (1995-2009).

Hung GY, Horng JL, Yen HJ, Lee CY, Lee YS - PLoS ONE (2015)

Temporal trends in age-standardized incidence rates of cancer in the patients aged 0–19 years in certain geographic areas (Northern, Central, and Southern Taiwan and in townships) in Taiwan (1995–2009).APC indicates annual percent change. * Statistical significance at the 0.05 level.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507945&req=5

pone.0133051.g002: Temporal trends in age-standardized incidence rates of cancer in the patients aged 0–19 years in certain geographic areas (Northern, Central, and Southern Taiwan and in townships) in Taiwan (1995–2009).APC indicates annual percent change. * Statistical significance at the 0.05 level.
Mentions: Fig 2 and Table 3 show the APCs in ASRs according to geographic factors. During the 15-year study period, the ASRs rose significantly in Southern (APC = 1.7%, 95% CI = 0.7–2.6) and Central Taiwan (APC = 1.3%, 95% CI = 0.2–2.4); however, the changes were nonsignificant in Northern and Eastern Taiwan. Regarding local administrative areas, significantly increasing trends were found in townships (APC = 1.8%, 95% CI = 0.8–2.7), and special municipalities (APC = 1.6%, 95% CI = 0.2–3.0). The variations in ASRs were nonsignificant in provincial cities, county-administered cities and aboriginal areas.

Bottom Line: Trend analysis showed that the most significant increase in incidence rate was observed at the township level, with an annual percent change of 1.8% during the 15-year study period.The high rate of childhood cancer in Northern Taiwan and at the township level deserves further attention.The potential impacts of environmental factors on the upward trend of childhood cancer incidence rate in townships warrant further investigation.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Hematology and Oncology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Pediatrics, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.

ABSTRACT

Background: Evidence from our recent study suggested that the overall trend for cancer incidence in children and adolescents has been increasing in Taiwan.

Methods: To analyze geographic variations in this trend, cancer frequencies and incidence rates of disease groups were quantified according to geographic areas among 12,633 patients aged <20 years during 1995-2009 by using the population-based Taiwan Cancer Registry. Three geographic levels were defined, namely county or city, region (Northern, Central, Southern, and Eastern Taiwan), and local administrative area (special municipality, provincial city, county-administered city, township, and aboriginal area).

Results: Of the regions, Northern Taiwan had the highest incidence rate at 139.6 per million person-years, followed by Central (132.8), Southern (131.8), and Eastern (128.4) Taiwan. Significantly higher standardized rate ratios (SRRs) were observed in Northern Taiwan (SRR = 1.06, 95% confidence interval [CI] = 1.02-1.10) and at the township level (SRR = 1.07, 95% CI = 1.03-1.11). Of the cities or counties, New Taipei City yielded the highest SRR (1.08), followed by Taipei City (SRR = 1.07). A comparison of the rates in the four regions and the remainder of Taiwan according to cancer type revealed that only the rate of neuroblastomas in Eastern Taiwan was significantly low. Trend analysis showed that the most significant increase in incidence rate was observed at the township level, with an annual percent change of 1.8% during the 15-year study period.

Conclusions: The high rate of childhood cancer in Northern Taiwan and at the township level deserves further attention. The potential impacts of environmental factors on the upward trend of childhood cancer incidence rate in townships warrant further investigation.

No MeSH data available.


Related in: MedlinePlus