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Geographic Variation in Cancer Incidence among Children and Adolescents in Taiwan (1995-2009).

Hung GY, Horng JL, Yen HJ, Lee CY, Lee YS - PLoS ONE (2015)

Bottom Line: Trend analysis showed that the most significant increase in incidence rate was observed at the township level, with an annual percent change of 1.8% during the 15-year study period.The high rate of childhood cancer in Northern Taiwan and at the township level deserves further attention.The potential impacts of environmental factors on the upward trend of childhood cancer incidence rate in townships warrant further investigation.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Hematology and Oncology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Pediatrics, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.

ABSTRACT

Background: Evidence from our recent study suggested that the overall trend for cancer incidence in children and adolescents has been increasing in Taiwan.

Methods: To analyze geographic variations in this trend, cancer frequencies and incidence rates of disease groups were quantified according to geographic areas among 12,633 patients aged <20 years during 1995-2009 by using the population-based Taiwan Cancer Registry. Three geographic levels were defined, namely county or city, region (Northern, Central, Southern, and Eastern Taiwan), and local administrative area (special municipality, provincial city, county-administered city, township, and aboriginal area).

Results: Of the regions, Northern Taiwan had the highest incidence rate at 139.6 per million person-years, followed by Central (132.8), Southern (131.8), and Eastern (128.4) Taiwan. Significantly higher standardized rate ratios (SRRs) were observed in Northern Taiwan (SRR = 1.06, 95% confidence interval [CI] = 1.02-1.10) and at the township level (SRR = 1.07, 95% CI = 1.03-1.11). Of the cities or counties, New Taipei City yielded the highest SRR (1.08), followed by Taipei City (SRR = 1.07). A comparison of the rates in the four regions and the remainder of Taiwan according to cancer type revealed that only the rate of neuroblastomas in Eastern Taiwan was significantly low. Trend analysis showed that the most significant increase in incidence rate was observed at the township level, with an annual percent change of 1.8% during the 15-year study period.

Conclusions: The high rate of childhood cancer in Northern Taiwan and at the township level deserves further attention. The potential impacts of environmental factors on the upward trend of childhood cancer incidence rate in townships warrant further investigation.

No MeSH data available.


Related in: MedlinePlus

Age-standardized incidence rates (per million person-years) of childhood cancer in patients aged 0–19 years among 22 cities and counties in Taiwan (1995–2009).Reproduced from Taiwan Geographic Name Information Systems [23], the figure is similar but not identical to the original image, and is therefore for illustrative purposes only.
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pone.0133051.g001: Age-standardized incidence rates (per million person-years) of childhood cancer in patients aged 0–19 years among 22 cities and counties in Taiwan (1995–2009).Reproduced from Taiwan Geographic Name Information Systems [23], the figure is similar but not identical to the original image, and is therefore for illustrative purposes only.

Mentions: Table 2 and Fig 1 show the case numbers, crude rates, and ASRs of childhood cancer among the 22 cities or counties in Taiwan as well as the averaged population densities and its changes during the 15-year study period of the 22 cities or counties. The 3 highest ASRs were 154.0, 149.5, and 144.3 per million person-years in Hsinchu, Keelung, and New Taipei Cities, respectively. Among the 22 cities or counties, the top 3 yielding the highest incidences of cancer cases were New Taipei City (n = 2179, 17.2%), Taichung City (n = 1532, 12.1%), and Taipei City (n = 1433, 11.3%). By contrast, the regions yielding the lowest relative frequencies were in the offshore islands, including Penghu (0.3%), Kinmen (0.2%), and Lienchiang Counties (0.02%). A comparison of the SRRs of the 22 cities or counties and the remaining area of Taiwan revealed significantly higher rates in Taipei City (SRR = 1.07, 95% CI = 1.01–1.13) and New Taipei City (SRR = 1.08, 95% CI = 1.03–1.13). In addition, the population densities of both cities were among the top 5 in Taiwan (ranked first and fifth among the 22 cities or counties). In contrast to the findings for Taipei City and New Taipei City, significantly lower rates were observed in Pingtung (SRR = 0.87, 95% CI = 0.80–0.95), Yilan (SRR = 0.86, 95% CI = 0.76–0.98), and Nantou Counties (SRR = 0.85, 95% CI = 0.75–0.95), for which the population densities ranked 17th, 19th, and 20th, respectively. No significant difference was determined in the rates of the 17 other cities or counties.


Geographic Variation in Cancer Incidence among Children and Adolescents in Taiwan (1995-2009).

Hung GY, Horng JL, Yen HJ, Lee CY, Lee YS - PLoS ONE (2015)

Age-standardized incidence rates (per million person-years) of childhood cancer in patients aged 0–19 years among 22 cities and counties in Taiwan (1995–2009).Reproduced from Taiwan Geographic Name Information Systems [23], the figure is similar but not identical to the original image, and is therefore for illustrative purposes only.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507945&req=5

pone.0133051.g001: Age-standardized incidence rates (per million person-years) of childhood cancer in patients aged 0–19 years among 22 cities and counties in Taiwan (1995–2009).Reproduced from Taiwan Geographic Name Information Systems [23], the figure is similar but not identical to the original image, and is therefore for illustrative purposes only.
Mentions: Table 2 and Fig 1 show the case numbers, crude rates, and ASRs of childhood cancer among the 22 cities or counties in Taiwan as well as the averaged population densities and its changes during the 15-year study period of the 22 cities or counties. The 3 highest ASRs were 154.0, 149.5, and 144.3 per million person-years in Hsinchu, Keelung, and New Taipei Cities, respectively. Among the 22 cities or counties, the top 3 yielding the highest incidences of cancer cases were New Taipei City (n = 2179, 17.2%), Taichung City (n = 1532, 12.1%), and Taipei City (n = 1433, 11.3%). By contrast, the regions yielding the lowest relative frequencies were in the offshore islands, including Penghu (0.3%), Kinmen (0.2%), and Lienchiang Counties (0.02%). A comparison of the SRRs of the 22 cities or counties and the remaining area of Taiwan revealed significantly higher rates in Taipei City (SRR = 1.07, 95% CI = 1.01–1.13) and New Taipei City (SRR = 1.08, 95% CI = 1.03–1.13). In addition, the population densities of both cities were among the top 5 in Taiwan (ranked first and fifth among the 22 cities or counties). In contrast to the findings for Taipei City and New Taipei City, significantly lower rates were observed in Pingtung (SRR = 0.87, 95% CI = 0.80–0.95), Yilan (SRR = 0.86, 95% CI = 0.76–0.98), and Nantou Counties (SRR = 0.85, 95% CI = 0.75–0.95), for which the population densities ranked 17th, 19th, and 20th, respectively. No significant difference was determined in the rates of the 17 other cities or counties.

Bottom Line: Trend analysis showed that the most significant increase in incidence rate was observed at the township level, with an annual percent change of 1.8% during the 15-year study period.The high rate of childhood cancer in Northern Taiwan and at the township level deserves further attention.The potential impacts of environmental factors on the upward trend of childhood cancer incidence rate in townships warrant further investigation.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Hematology and Oncology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Pediatrics, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.

ABSTRACT

Background: Evidence from our recent study suggested that the overall trend for cancer incidence in children and adolescents has been increasing in Taiwan.

Methods: To analyze geographic variations in this trend, cancer frequencies and incidence rates of disease groups were quantified according to geographic areas among 12,633 patients aged <20 years during 1995-2009 by using the population-based Taiwan Cancer Registry. Three geographic levels were defined, namely county or city, region (Northern, Central, Southern, and Eastern Taiwan), and local administrative area (special municipality, provincial city, county-administered city, township, and aboriginal area).

Results: Of the regions, Northern Taiwan had the highest incidence rate at 139.6 per million person-years, followed by Central (132.8), Southern (131.8), and Eastern (128.4) Taiwan. Significantly higher standardized rate ratios (SRRs) were observed in Northern Taiwan (SRR = 1.06, 95% confidence interval [CI] = 1.02-1.10) and at the township level (SRR = 1.07, 95% CI = 1.03-1.11). Of the cities or counties, New Taipei City yielded the highest SRR (1.08), followed by Taipei City (SRR = 1.07). A comparison of the rates in the four regions and the remainder of Taiwan according to cancer type revealed that only the rate of neuroblastomas in Eastern Taiwan was significantly low. Trend analysis showed that the most significant increase in incidence rate was observed at the township level, with an annual percent change of 1.8% during the 15-year study period.

Conclusions: The high rate of childhood cancer in Northern Taiwan and at the township level deserves further attention. The potential impacts of environmental factors on the upward trend of childhood cancer incidence rate in townships warrant further investigation.

No MeSH data available.


Related in: MedlinePlus