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Results of surgical management of renal cell carcinoma metastatic to the pancreas.

Kusnierz K, Mrowiec S, Lampe P - Contemp Oncol (Pozn) (2014)

Bottom Line: Operative mortality was 0%.In our group of 7 deceased patients the mean survival was 19 months (median 16 months).In our series a large number of patients with occurrence of symptoms, advancement of tumours, metastases to lymph node, and positive margin were connected with short survival period.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastrointestinal Surgery, Medical University of Silesia, Katowice, Poland.

ABSTRACT

Aim of the study: Metastases from renal cell carcinoma represent between 0.25% and 3.00% of all resected pancreatic tumours. The aim of this study was to review 13 patients with renal cell carcinoma metastatic to the pancreas.

Material and methods: Clinical data, time from initial presentation, operative outcome, long-term survival, tumour size, presence of lymphatic invasion, and surgical margin status were evaluated.

Results: The median age of the patients was 62 years (mean 60.9). The median time for appearance of metastatic disease following resection of the primary tumour was 9 years (mean 8.38). Pancreatic metastases were located in the head of the pancreas in four patients, in the body in three, in the tail in two patients, and four patients had multiple pancreatic localisations. Four (30.7%) pancreatoduodenectomies, 5 (38.5%) distal resections, 2 (15.3%) total pancreatectomies, 1 (7.6%) enucleation, and 1 (7.6%) Roux duodenojejunostomy were performed. Two patients (15.3%) had postoperative complications. Operative mortality was 0%. Surgical margins were microscopically positive in 1 (8.3%) patient, and lymph nodes were positive in 2 (16.6%) patients. In our group of 7 deceased patients the mean survival was 19 months (median 16 months).

Conclusions: Renal cell carcinoma metastatic to the pancreas can occur several years after nephrectomy. In our series a large number of patients with occurrence of symptoms, advancement of tumours, metastases to lymph node, and positive margin were connected with short survival period. Early detection of primary tumour, long and thorough patient care, and radical resections give patients a chance for a prolonged life.

No MeSH data available.


Related in: MedlinePlus

A computed tomography scan of the abdomen showing pancreatic metastases from renal cell carcinoma with typical hypervascular features
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Figure 0001: A computed tomography scan of the abdomen showing pancreatic metastases from renal cell carcinoma with typical hypervascular features

Mentions: A retrospective review of 13 patients undergoing surgical management at the Department of Gastrointestinal Surgery for renal cell carcinoma metastatic to the pancreas was performed. Clinical data included sex, age, symptoms, medical history, time from initial presentation, other metastatic sites, operative outcome, and long-term survival after pancreatic resection. All patients underwent chest radiography, abdominal ultrasonography, and computed tomography (CT). The typical feature on CT was a hypervascularised pancreatic mass [10] (Fig. 1). Tumour size, histological type, the presence of lymphatic invasion, and surgical margin status were evaluated. All patients in the study had a known primary renal cell carcinoma, and the final pathology report on the pancreatic specimen was consistent with renal cell carcinoma. Patients with primary pancreatic malignancies were excluded. All resections were standard resections in which only the lymph nodes in the tumour specimen were removed. Surgical morbidity and mortality were defined as occurring within 30 days of the operation. Follow-up information was obtained through the patient or the patient's family.


Results of surgical management of renal cell carcinoma metastatic to the pancreas.

Kusnierz K, Mrowiec S, Lampe P - Contemp Oncol (Pozn) (2014)

A computed tomography scan of the abdomen showing pancreatic metastases from renal cell carcinoma with typical hypervascular features
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507895&req=5

Figure 0001: A computed tomography scan of the abdomen showing pancreatic metastases from renal cell carcinoma with typical hypervascular features
Mentions: A retrospective review of 13 patients undergoing surgical management at the Department of Gastrointestinal Surgery for renal cell carcinoma metastatic to the pancreas was performed. Clinical data included sex, age, symptoms, medical history, time from initial presentation, other metastatic sites, operative outcome, and long-term survival after pancreatic resection. All patients underwent chest radiography, abdominal ultrasonography, and computed tomography (CT). The typical feature on CT was a hypervascularised pancreatic mass [10] (Fig. 1). Tumour size, histological type, the presence of lymphatic invasion, and surgical margin status were evaluated. All patients in the study had a known primary renal cell carcinoma, and the final pathology report on the pancreatic specimen was consistent with renal cell carcinoma. Patients with primary pancreatic malignancies were excluded. All resections were standard resections in which only the lymph nodes in the tumour specimen were removed. Surgical morbidity and mortality were defined as occurring within 30 days of the operation. Follow-up information was obtained through the patient or the patient's family.

Bottom Line: Operative mortality was 0%.In our group of 7 deceased patients the mean survival was 19 months (median 16 months).In our series a large number of patients with occurrence of symptoms, advancement of tumours, metastases to lymph node, and positive margin were connected with short survival period.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastrointestinal Surgery, Medical University of Silesia, Katowice, Poland.

ABSTRACT

Aim of the study: Metastases from renal cell carcinoma represent between 0.25% and 3.00% of all resected pancreatic tumours. The aim of this study was to review 13 patients with renal cell carcinoma metastatic to the pancreas.

Material and methods: Clinical data, time from initial presentation, operative outcome, long-term survival, tumour size, presence of lymphatic invasion, and surgical margin status were evaluated.

Results: The median age of the patients was 62 years (mean 60.9). The median time for appearance of metastatic disease following resection of the primary tumour was 9 years (mean 8.38). Pancreatic metastases were located in the head of the pancreas in four patients, in the body in three, in the tail in two patients, and four patients had multiple pancreatic localisations. Four (30.7%) pancreatoduodenectomies, 5 (38.5%) distal resections, 2 (15.3%) total pancreatectomies, 1 (7.6%) enucleation, and 1 (7.6%) Roux duodenojejunostomy were performed. Two patients (15.3%) had postoperative complications. Operative mortality was 0%. Surgical margins were microscopically positive in 1 (8.3%) patient, and lymph nodes were positive in 2 (16.6%) patients. In our group of 7 deceased patients the mean survival was 19 months (median 16 months).

Conclusions: Renal cell carcinoma metastatic to the pancreas can occur several years after nephrectomy. In our series a large number of patients with occurrence of symptoms, advancement of tumours, metastases to lymph node, and positive margin were connected with short survival period. Early detection of primary tumour, long and thorough patient care, and radical resections give patients a chance for a prolonged life.

No MeSH data available.


Related in: MedlinePlus