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P27 expression in pleomorphic salivary gland adenoma.

Tarakji B, Umair A, Altamimi MA, Azzeghaiby SN, Mahmoud AS, Darwish S, Nassani MZ, Ashok N - Contemp Oncol (Pozn) (2014)

Bottom Line: The percentage of p27-positive nuclei was semi-quantitatively assessed by two independent observers and scores were given.The statistical analysis included the use of descriptive statistics and proportional frequencies.The results showed that P27 nuclear staining with high staining (moderate to strong positive staining in more than 50% of nuclei, depending on the percentage of nuclei for the cells) was noted in tumour duct cells of pleomorphic adenoma in 90 (75%) cases out of 120, while 30 (25%) cases showed low staining (positive staining in less than 5% of nuclei, depending on the percentage of nuclei for the cells).

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia.

ABSTRACT

Aim of the study: This study aims to characterise alterations in the immunohistochemical expression of p27 in normal tissue of the salivary gland surrounding pleomorphic adenoma and in the tumour cells of pleomorphic adenoma.

Material and methods: A retrospective study of data including 120 cases of pleomorphic adenomas (66 female, 54 male) retrieved from the files of the Oral Pathology Departments of Aleppo University, Syria and Al-Farabi Dental and Nursing College. Immunohistochemical expression against p27 was examined in the selected cases. The percentage of p27-positive nuclei was semi-quantitatively assessed by two independent observers and scores were given. The statistical analysis included the use of descriptive statistics and proportional frequencies.

Results: The results showed that P27 nuclear staining with high staining (moderate to strong positive staining in more than 50% of nuclei, depending on the percentage of nuclei for the cells) was noted in tumour duct cells of pleomorphic adenoma in 90 (75%) cases out of 120, while 30 (25%) cases showed low staining (positive staining in less than 5% of nuclei, depending on the percentage of nuclei for the cells).

Conclusions: Our data suggests that p27 might have a minor role in the development of pleomorphic adenoma.

No MeSH data available.


Related in: MedlinePlus

P27 nuclear staining with low staining in tumour duct cells of pleomorphic adenoma
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Figure 0002: P27 nuclear staining with low staining in tumour duct cells of pleomorphic adenoma

Mentions: P27 nuclear staining with high staining was noted in tumour duct cells of PA in 90 (75%) cases out of 120 (Fig. 1), while 30 (25%) cases showed low staining (Fig. 2, Table 1). P27 nuclear staining in myxochondroid tissue was identified in 98 (81.6%) cases with high staining, while 22 (18.3%) cases had low staining.


P27 expression in pleomorphic salivary gland adenoma.

Tarakji B, Umair A, Altamimi MA, Azzeghaiby SN, Mahmoud AS, Darwish S, Nassani MZ, Ashok N - Contemp Oncol (Pozn) (2014)

P27 nuclear staining with low staining in tumour duct cells of pleomorphic adenoma
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507890&req=5

Figure 0002: P27 nuclear staining with low staining in tumour duct cells of pleomorphic adenoma
Mentions: P27 nuclear staining with high staining was noted in tumour duct cells of PA in 90 (75%) cases out of 120 (Fig. 1), while 30 (25%) cases showed low staining (Fig. 2, Table 1). P27 nuclear staining in myxochondroid tissue was identified in 98 (81.6%) cases with high staining, while 22 (18.3%) cases had low staining.

Bottom Line: The percentage of p27-positive nuclei was semi-quantitatively assessed by two independent observers and scores were given.The statistical analysis included the use of descriptive statistics and proportional frequencies.The results showed that P27 nuclear staining with high staining (moderate to strong positive staining in more than 50% of nuclei, depending on the percentage of nuclei for the cells) was noted in tumour duct cells of pleomorphic adenoma in 90 (75%) cases out of 120, while 30 (25%) cases showed low staining (positive staining in less than 5% of nuclei, depending on the percentage of nuclei for the cells).

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia.

ABSTRACT

Aim of the study: This study aims to characterise alterations in the immunohistochemical expression of p27 in normal tissue of the salivary gland surrounding pleomorphic adenoma and in the tumour cells of pleomorphic adenoma.

Material and methods: A retrospective study of data including 120 cases of pleomorphic adenomas (66 female, 54 male) retrieved from the files of the Oral Pathology Departments of Aleppo University, Syria and Al-Farabi Dental and Nursing College. Immunohistochemical expression against p27 was examined in the selected cases. The percentage of p27-positive nuclei was semi-quantitatively assessed by two independent observers and scores were given. The statistical analysis included the use of descriptive statistics and proportional frequencies.

Results: The results showed that P27 nuclear staining with high staining (moderate to strong positive staining in more than 50% of nuclei, depending on the percentage of nuclei for the cells) was noted in tumour duct cells of pleomorphic adenoma in 90 (75%) cases out of 120, while 30 (25%) cases showed low staining (positive staining in less than 5% of nuclei, depending on the percentage of nuclei for the cells).

Conclusions: Our data suggests that p27 might have a minor role in the development of pleomorphic adenoma.

No MeSH data available.


Related in: MedlinePlus