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Analysis of the influence of parenteral cancer chemotherapy on the health condition of oral mucosa.

Rahnama M, Madej-Czerwonka B, Jastrzębska-Jamrogiewicz I, Jamrogiewicz R - Contemp Oncol (Pozn) (2015)

Bottom Line: Patients in the study group frequently complained about the presence of dry mouth, taste disturbances, nausea, and vomiting.These symptoms occurred in 70% of patients undergoing oncological treatment.In both stimulated and unstimulated saliva secretion, the rates were significantly lower in patients from the research group, when compared to the control group.

View Article: PubMed Central - PubMed

Affiliation: The Chair and Department of Oral Surgery, Medical University of Lublin, Lublin, Poland.

ABSTRACT

Aim of the study: The present study was aimed at estimating the prevalence of oral complications in cancer patients receiving chemotherapy.

Material and methods: The study was conducted on a group of 58 patients treated with chemotherapy (study group). The control group consisted of 30 healthy patients. Dental status and oral mucosa were examined using the criteria of the National Cancer Institute Toxicity Criteria Scale. The levels of stimulated and unstimulated saliva flow were analysed.

Results: In the group of patients treated with chemotherapy, 59% of patients had inflammatory changes of the soft tissues of the mouth, such as erythema, erosions, or ulcers, which were discovered during dental examination. Such changes occurred in only 10% of patients in the control group. Six of the patients treated with chemotherapy reported pain with intensity was so severe that it caused swallowing difficulties. Patients in the study group frequently complained about the presence of dry mouth, taste disturbances, nausea, and vomiting. These symptoms occurred in 70% of patients undergoing oncological treatment. In both stimulated and unstimulated saliva secretion, the rates were significantly lower in patients from the research group, when compared to the control group.

No MeSH data available.


Related in: MedlinePlus

The incidence of pathological lesions of the mucous membranes in patients treated with chemotherapy
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Figure 0001: The incidence of pathological lesions of the mucous membranes in patients treated with chemotherapy

Mentions: A comparison of the severity and frequency of pathological changes occurrence in the oral cavity of patients in the control and the study group is presented in Tables 1 and 2. In 90% of patients from the control group no mucosal lesions in the oral cavity were detected. Only erythema and mild soreness were discovered in healthy patients. In the group of patients treated with chemotherapy, nearly 59% of patients had inflammatory changes of the soft tissues. Pathological lesions among healthy patients were less severe and were limited to painless redness or erosions, while inflammation in the study groups had a significantly higher intensity than in the healthy group. Lesions causing pain occurred in over 27% of patients. One of the patients treated with chemotherapy reported pain so intensive that it made it impossible to intake food. In addition, examination of the study group revealed fungal infection in 50% of patients, compared with one fungal infection in the control group (Fig. 1).


Analysis of the influence of parenteral cancer chemotherapy on the health condition of oral mucosa.

Rahnama M, Madej-Czerwonka B, Jastrzębska-Jamrogiewicz I, Jamrogiewicz R - Contemp Oncol (Pozn) (2015)

The incidence of pathological lesions of the mucous membranes in patients treated with chemotherapy
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507886&req=5

Figure 0001: The incidence of pathological lesions of the mucous membranes in patients treated with chemotherapy
Mentions: A comparison of the severity and frequency of pathological changes occurrence in the oral cavity of patients in the control and the study group is presented in Tables 1 and 2. In 90% of patients from the control group no mucosal lesions in the oral cavity were detected. Only erythema and mild soreness were discovered in healthy patients. In the group of patients treated with chemotherapy, nearly 59% of patients had inflammatory changes of the soft tissues. Pathological lesions among healthy patients were less severe and were limited to painless redness or erosions, while inflammation in the study groups had a significantly higher intensity than in the healthy group. Lesions causing pain occurred in over 27% of patients. One of the patients treated with chemotherapy reported pain so intensive that it made it impossible to intake food. In addition, examination of the study group revealed fungal infection in 50% of patients, compared with one fungal infection in the control group (Fig. 1).

Bottom Line: Patients in the study group frequently complained about the presence of dry mouth, taste disturbances, nausea, and vomiting.These symptoms occurred in 70% of patients undergoing oncological treatment.In both stimulated and unstimulated saliva secretion, the rates were significantly lower in patients from the research group, when compared to the control group.

View Article: PubMed Central - PubMed

Affiliation: The Chair and Department of Oral Surgery, Medical University of Lublin, Lublin, Poland.

ABSTRACT

Aim of the study: The present study was aimed at estimating the prevalence of oral complications in cancer patients receiving chemotherapy.

Material and methods: The study was conducted on a group of 58 patients treated with chemotherapy (study group). The control group consisted of 30 healthy patients. Dental status and oral mucosa were examined using the criteria of the National Cancer Institute Toxicity Criteria Scale. The levels of stimulated and unstimulated saliva flow were analysed.

Results: In the group of patients treated with chemotherapy, 59% of patients had inflammatory changes of the soft tissues of the mouth, such as erythema, erosions, or ulcers, which were discovered during dental examination. Such changes occurred in only 10% of patients in the control group. Six of the patients treated with chemotherapy reported pain with intensity was so severe that it caused swallowing difficulties. Patients in the study group frequently complained about the presence of dry mouth, taste disturbances, nausea, and vomiting. These symptoms occurred in 70% of patients undergoing oncological treatment. In both stimulated and unstimulated saliva secretion, the rates were significantly lower in patients from the research group, when compared to the control group.

No MeSH data available.


Related in: MedlinePlus