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Underrecognized comorbidities of chronic obstructive pulmonary disease.

Miłkowska-Dymanowska J, Białas AJ, Zalewska-Janowska A, Górski P, Piotrowski WJ - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: Some comorbidities are well acknowledged and established in doctors' awareness.We call them underrecognized comorbidities, and the reason why this is so may be related to their relatively low clinical significance, inefficient literature data, or data ambiguity.In this review, we describe rhinosinusitis, skin abnormalities, eye diseases, different endocrinological disorders, and gastroesophageal reflux disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Pneumology and Allergy, 1st Chair of Internal Medicine, Medical University of Lodz, Łódź, Poland ; Healthy Aging Research Centre (HARC), Medical University of Lodz, Łódź, Poland.

ABSTRACT
COPD is associated with different comorbid diseases, and their frequency increases with age. Comorbidities severely impact costs of health care, intensity of symptoms, quality of life and, most importantly, may contribute to life span shortening. Some comorbidities are well acknowledged and established in doctors' awareness. However, both everyday practice and literature searches provide evidence of other, less recognized diseases, which are frequently associated with COPD. We call them underrecognized comorbidities, and the reason why this is so may be related to their relatively low clinical significance, inefficient literature data, or data ambiguity. In this review, we describe rhinosinusitis, skin abnormalities, eye diseases, different endocrinological disorders, and gastroesophageal reflux disease. Possible links to COPD pathogenesis have been discussed, if the data were available.

No MeSH data available.


Related in: MedlinePlus

The prevalence of comorbidities in COPD (prevalence >2%).Notes: The diseases that are the topic of this study are marked in dark blue. Prevalence was calculated as a weighted average based on the study’s sample size. When the data in a manuscript were unclear, the researchers contacted the corresponding author of the manuscript.8,18,30,31,33,39,52,62,82,83,86,89–91,95–104 The calculations were performed and the graph was made in Microsoft Excel 2013.Abbreviations: GERD, gastroesophageal reflux disease; MI, myocardial infarction.
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f1-copd-10-1331: The prevalence of comorbidities in COPD (prevalence >2%).Notes: The diseases that are the topic of this study are marked in dark blue. Prevalence was calculated as a weighted average based on the study’s sample size. When the data in a manuscript were unclear, the researchers contacted the corresponding author of the manuscript.8,18,30,31,33,39,52,62,82,83,86,89–91,95–104 The calculations were performed and the graph was made in Microsoft Excel 2013.Abbreviations: GERD, gastroesophageal reflux disease; MI, myocardial infarction.

Mentions: COPD is a complex, multicomponent disease associated with pulmonary and extrapulmonary manifestations.1,2 More than 30% of patients have one additional chronic disease, and another 40% have two or more comorbidities.2,3 Comorbid diseases prolong hospitalization and are risk factors of short- and long-term unfavorable prognoses.4 They are undeniably related to increased health care costs5,6 and decreased quality of life.3,7 Depression, anxiety, peripheral artery disease, cerebrovascular disease, and symptomatic heart failure have been defined as those concurrent conditions that most severely impact patients health status.8 Some COPD-associated diseases are well recognized and are listed in official documents on COPD, such as the Global Initiative for Chronic Obstructive Lung Disease (GOLD). They include: cardiovascular diseases (CVDs) (ischemic heart disease, heart failure, atrial fibrillation, hypertension); osteoporosis (frequently associated with weight loss and sarcopenia); anxiety and depression; lung cancer; infections; metabolic syndrome and diabetes; bronchiectasis; and impaired cognitive function.9Figures 1 and 2 shows the prevalence of different chronic conditions, including underrecognized comorbidities discussed in this paper in patients suffering from COPD, on the basis of the available literature.


Underrecognized comorbidities of chronic obstructive pulmonary disease.

Miłkowska-Dymanowska J, Białas AJ, Zalewska-Janowska A, Górski P, Piotrowski WJ - Int J Chron Obstruct Pulmon Dis (2015)

The prevalence of comorbidities in COPD (prevalence >2%).Notes: The diseases that are the topic of this study are marked in dark blue. Prevalence was calculated as a weighted average based on the study’s sample size. When the data in a manuscript were unclear, the researchers contacted the corresponding author of the manuscript.8,18,30,31,33,39,52,62,82,83,86,89–91,95–104 The calculations were performed and the graph was made in Microsoft Excel 2013.Abbreviations: GERD, gastroesophageal reflux disease; MI, myocardial infarction.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507790&req=5

f1-copd-10-1331: The prevalence of comorbidities in COPD (prevalence >2%).Notes: The diseases that are the topic of this study are marked in dark blue. Prevalence was calculated as a weighted average based on the study’s sample size. When the data in a manuscript were unclear, the researchers contacted the corresponding author of the manuscript.8,18,30,31,33,39,52,62,82,83,86,89–91,95–104 The calculations were performed and the graph was made in Microsoft Excel 2013.Abbreviations: GERD, gastroesophageal reflux disease; MI, myocardial infarction.
Mentions: COPD is a complex, multicomponent disease associated with pulmonary and extrapulmonary manifestations.1,2 More than 30% of patients have one additional chronic disease, and another 40% have two or more comorbidities.2,3 Comorbid diseases prolong hospitalization and are risk factors of short- and long-term unfavorable prognoses.4 They are undeniably related to increased health care costs5,6 and decreased quality of life.3,7 Depression, anxiety, peripheral artery disease, cerebrovascular disease, and symptomatic heart failure have been defined as those concurrent conditions that most severely impact patients health status.8 Some COPD-associated diseases are well recognized and are listed in official documents on COPD, such as the Global Initiative for Chronic Obstructive Lung Disease (GOLD). They include: cardiovascular diseases (CVDs) (ischemic heart disease, heart failure, atrial fibrillation, hypertension); osteoporosis (frequently associated with weight loss and sarcopenia); anxiety and depression; lung cancer; infections; metabolic syndrome and diabetes; bronchiectasis; and impaired cognitive function.9Figures 1 and 2 shows the prevalence of different chronic conditions, including underrecognized comorbidities discussed in this paper in patients suffering from COPD, on the basis of the available literature.

Bottom Line: Some comorbidities are well acknowledged and established in doctors' awareness.We call them underrecognized comorbidities, and the reason why this is so may be related to their relatively low clinical significance, inefficient literature data, or data ambiguity.In this review, we describe rhinosinusitis, skin abnormalities, eye diseases, different endocrinological disorders, and gastroesophageal reflux disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Pneumology and Allergy, 1st Chair of Internal Medicine, Medical University of Lodz, Łódź, Poland ; Healthy Aging Research Centre (HARC), Medical University of Lodz, Łódź, Poland.

ABSTRACT
COPD is associated with different comorbid diseases, and their frequency increases with age. Comorbidities severely impact costs of health care, intensity of symptoms, quality of life and, most importantly, may contribute to life span shortening. Some comorbidities are well acknowledged and established in doctors' awareness. However, both everyday practice and literature searches provide evidence of other, less recognized diseases, which are frequently associated with COPD. We call them underrecognized comorbidities, and the reason why this is so may be related to their relatively low clinical significance, inefficient literature data, or data ambiguity. In this review, we describe rhinosinusitis, skin abnormalities, eye diseases, different endocrinological disorders, and gastroesophageal reflux disease. Possible links to COPD pathogenesis have been discussed, if the data were available.

No MeSH data available.


Related in: MedlinePlus