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Magnetic-particle-sensing based diagnostic protocols and applications.

Takamura T, Ko PJ, Sharma J, Yukino R, Ishizawa S, Sandhu A - Sensors (Basel) (2015)

Bottom Line: First, the detection by Hall magnetic sensor with lock-in amplifier and alternative magnetic field is summarized.Then, our approach to detect sub-200 nm diameter target magnetic particles via relatively large micoro-sized "columnar particles" by optical microscopy is described.Subsequently, we summarize magnetic particle detection based on optical techniques; one method is based on the scattering of the magnetically-assembled nano-sized magnetic bead chain in rotating magnetic fields and the other one is based on the reflection of magnetic target particles and porous silicon.

View Article: PubMed Central - PubMed

Affiliation: Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku, Toyohashi, Aichi 441-8580, Japan. takamura@eiiris.tut.ac.jp.

ABSTRACT
Magnetic particle-labeled biomaterial detection has attracted much attention in recent years for a number of reasons; easy manipulation by external magnetic fields, easy functionalization of the surface, and large surface-to-volume ratio, to name but a few. In this review, we report on our recent investigations into the detection of nano-sized magnetic particles. First, the detection by Hall magnetic sensor with lock-in amplifier and alternative magnetic field is summarized. Then, our approach to detect sub-200 nm diameter target magnetic particles via relatively large micoro-sized "columnar particles" by optical microscopy is described. Subsequently, we summarize magnetic particle detection based on optical techniques; one method is based on the scattering of the magnetically-assembled nano-sized magnetic bead chain in rotating magnetic fields and the other one is based on the reflection of magnetic target particles and porous silicon. Finally, we report recent works with reference to more familiar industrial products (such as smartphone-based medical diagnosis systems and magnetic removal of unspecific-binded nano-sized particles, or "magnetic washing").

No MeSH data available.


Related in: MedlinePlus

The basic concept of “magnetic washing” via magnetic field gradient, induced by an applied current thorough a gold layer. Adapted from [14].
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sensors-15-12983-f021: The basic concept of “magnetic washing” via magnetic field gradient, induced by an applied current thorough a gold layer. Adapted from [14].

Mentions: We are also developing the technique of “magnetic washing” for magnetically removing nonspecifically-bonded nano-sized particles on the surfaces of biosensors. Our approach is based on a magnetic field gradient induced by a current passed through gold micro-lines integrated with the substrate [14] as shown schematically in Figure 21. The magnitude of the magnetic field gradient is controlled by varying the dimensions of the gold pattern microlines as described in a report on Hall effect biosensors.


Magnetic-particle-sensing based diagnostic protocols and applications.

Takamura T, Ko PJ, Sharma J, Yukino R, Ishizawa S, Sandhu A - Sensors (Basel) (2015)

The basic concept of “magnetic washing” via magnetic field gradient, induced by an applied current thorough a gold layer. Adapted from [14].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507658&req=5

sensors-15-12983-f021: The basic concept of “magnetic washing” via magnetic field gradient, induced by an applied current thorough a gold layer. Adapted from [14].
Mentions: We are also developing the technique of “magnetic washing” for magnetically removing nonspecifically-bonded nano-sized particles on the surfaces of biosensors. Our approach is based on a magnetic field gradient induced by a current passed through gold micro-lines integrated with the substrate [14] as shown schematically in Figure 21. The magnitude of the magnetic field gradient is controlled by varying the dimensions of the gold pattern microlines as described in a report on Hall effect biosensors.

Bottom Line: First, the detection by Hall magnetic sensor with lock-in amplifier and alternative magnetic field is summarized.Then, our approach to detect sub-200 nm diameter target magnetic particles via relatively large micoro-sized "columnar particles" by optical microscopy is described.Subsequently, we summarize magnetic particle detection based on optical techniques; one method is based on the scattering of the magnetically-assembled nano-sized magnetic bead chain in rotating magnetic fields and the other one is based on the reflection of magnetic target particles and porous silicon.

View Article: PubMed Central - PubMed

Affiliation: Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku, Toyohashi, Aichi 441-8580, Japan. takamura@eiiris.tut.ac.jp.

ABSTRACT
Magnetic particle-labeled biomaterial detection has attracted much attention in recent years for a number of reasons; easy manipulation by external magnetic fields, easy functionalization of the surface, and large surface-to-volume ratio, to name but a few. In this review, we report on our recent investigations into the detection of nano-sized magnetic particles. First, the detection by Hall magnetic sensor with lock-in amplifier and alternative magnetic field is summarized. Then, our approach to detect sub-200 nm diameter target magnetic particles via relatively large micoro-sized "columnar particles" by optical microscopy is described. Subsequently, we summarize magnetic particle detection based on optical techniques; one method is based on the scattering of the magnetically-assembled nano-sized magnetic bead chain in rotating magnetic fields and the other one is based on the reflection of magnetic target particles and porous silicon. Finally, we report recent works with reference to more familiar industrial products (such as smartphone-based medical diagnosis systems and magnetic removal of unspecific-binded nano-sized particles, or "magnetic washing").

No MeSH data available.


Related in: MedlinePlus