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A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo.

Gong CS, Lai HY, Huang SH, Lo YC, Lee N, Chen PY, Tu PH, Yang CY, Lin JC, Chen YY - Sensors (Basel) (2015)

Bottom Line: This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency.The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure.The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical Engineering, Chang Gung University, No. 259 Wen-Hwa 1st Rd., Guishan Township, Taoyuan County 333, Taiwan. alex.mlead@gmail.com.

ABSTRACT
Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. The DBS neurosurgical procedure involves the implantation of a DBS device and a battery-operated neurotransmitter, which delivers electrical impulses to treatment targets through implanted electrodes. The DBS modulates the neuronal activities in the brain nucleus for improving physiological responses as long as an electric discharge above the stimulation threshold can be achieved. In an effort to improve the performance of an implanted DBS device, the device size, implementation cost, and power efficiency are among the most important DBS device design aspects. This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency. The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure. The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.

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Related in: MedlinePlus

Simulated and measured voltage conversion efficiencies (VCEs) vs. a dummy load (RS).
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sensors-15-12700-f010: Simulated and measured voltage conversion efficiencies (VCEs) vs. a dummy load (RS).

Mentions: The resistor RM and capacitor CF are precise components used to emulate the practical conditions of the interface. The interface with the target of interest can be represented by the half-cell potential consisting of an R//C-R network [36]. The chip characterization experiments were performed for understanding the real device output performance and efficiency. The VCE measurement exhibited the highest efficiency at about 95% under a dummy load (RS) of 100 kΩ (Figure 10). The measurement and simulation results of the chip were in good agreement with each other. The VCE measurements showed better device efficiencies than what was demonstrated in the simulations. This increase in efficiency can be attributed to the overestimation parasitic effect of the involved transistors. The fabricated stimulators have almost identical circuit performances. Figure 11 shows the oscilloscope traces of the prototype stimulator working at 9 V DC with a RS of 100 kΩ. The input signal used to switch the stimulator is at 1-kHz clock speed. The highest output potential of the stimulator is almost triple that of the input signal.


A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo.

Gong CS, Lai HY, Huang SH, Lo YC, Lee N, Chen PY, Tu PH, Yang CY, Lin JC, Chen YY - Sensors (Basel) (2015)

Simulated and measured voltage conversion efficiencies (VCEs) vs. a dummy load (RS).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507613&req=5

sensors-15-12700-f010: Simulated and measured voltage conversion efficiencies (VCEs) vs. a dummy load (RS).
Mentions: The resistor RM and capacitor CF are precise components used to emulate the practical conditions of the interface. The interface with the target of interest can be represented by the half-cell potential consisting of an R//C-R network [36]. The chip characterization experiments were performed for understanding the real device output performance and efficiency. The VCE measurement exhibited the highest efficiency at about 95% under a dummy load (RS) of 100 kΩ (Figure 10). The measurement and simulation results of the chip were in good agreement with each other. The VCE measurements showed better device efficiencies than what was demonstrated in the simulations. This increase in efficiency can be attributed to the overestimation parasitic effect of the involved transistors. The fabricated stimulators have almost identical circuit performances. Figure 11 shows the oscilloscope traces of the prototype stimulator working at 9 V DC with a RS of 100 kΩ. The input signal used to switch the stimulator is at 1-kHz clock speed. The highest output potential of the stimulator is almost triple that of the input signal.

Bottom Line: This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency.The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure.The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical Engineering, Chang Gung University, No. 259 Wen-Hwa 1st Rd., Guishan Township, Taoyuan County 333, Taiwan. alex.mlead@gmail.com.

ABSTRACT
Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. The DBS neurosurgical procedure involves the implantation of a DBS device and a battery-operated neurotransmitter, which delivers electrical impulses to treatment targets through implanted electrodes. The DBS modulates the neuronal activities in the brain nucleus for improving physiological responses as long as an electric discharge above the stimulation threshold can be achieved. In an effort to improve the performance of an implanted DBS device, the device size, implementation cost, and power efficiency are among the most important DBS device design aspects. This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency. The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure. The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.

Show MeSH
Related in: MedlinePlus