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A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo.

Gong CS, Lai HY, Huang SH, Lo YC, Lee N, Chen PY, Tu PH, Yang CY, Lin JC, Chen YY - Sensors (Basel) (2015)

Bottom Line: This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency.The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure.The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical Engineering, Chang Gung University, No. 259 Wen-Hwa 1st Rd., Guishan Township, Taoyuan County 333, Taiwan. alex.mlead@gmail.com.

ABSTRACT
Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. The DBS neurosurgical procedure involves the implantation of a DBS device and a battery-operated neurotransmitter, which delivers electrical impulses to treatment targets through implanted electrodes. The DBS modulates the neuronal activities in the brain nucleus for improving physiological responses as long as an electric discharge above the stimulation threshold can be achieved. In an effort to improve the performance of an implanted DBS device, the device size, implementation cost, and power efficiency are among the most important DBS device design aspects. This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency. The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure. The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.

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Neural stimulator measurement setup.
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sensors-15-12700-f009: Neural stimulator measurement setup.

Mentions: Figure 8 shows the die photo of the fabricated chip that supports for up to 9 V of stimulation voltage. The voltage conversion efficiency (VCE) was measured as the output voltage, with a dummy load representing the practical conditions, divided by the power supply and was expressed as a percentage. The measurement setup of the proposed stimulator function is illustrated in Figure 9. The Startup function served as a fail-safe soft-start mechanism. It was designed to set the initial voltages of the internal stimulator nodes after power-on to prevent overstress failure and transistor breakdown. A function/agilent waveform generator (33120A, Hewlett Packard, Palo Alto, CA, USA) was used to control the stimulus pulse parameters.


A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo.

Gong CS, Lai HY, Huang SH, Lo YC, Lee N, Chen PY, Tu PH, Yang CY, Lin JC, Chen YY - Sensors (Basel) (2015)

Neural stimulator measurement setup.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507613&req=5

sensors-15-12700-f009: Neural stimulator measurement setup.
Mentions: Figure 8 shows the die photo of the fabricated chip that supports for up to 9 V of stimulation voltage. The voltage conversion efficiency (VCE) was measured as the output voltage, with a dummy load representing the practical conditions, divided by the power supply and was expressed as a percentage. The measurement setup of the proposed stimulator function is illustrated in Figure 9. The Startup function served as a fail-safe soft-start mechanism. It was designed to set the initial voltages of the internal stimulator nodes after power-on to prevent overstress failure and transistor breakdown. A function/agilent waveform generator (33120A, Hewlett Packard, Palo Alto, CA, USA) was used to control the stimulus pulse parameters.

Bottom Line: This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency.The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure.The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical Engineering, Chang Gung University, No. 259 Wen-Hwa 1st Rd., Guishan Township, Taoyuan County 333, Taiwan. alex.mlead@gmail.com.

ABSTRACT
Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. The DBS neurosurgical procedure involves the implantation of a DBS device and a battery-operated neurotransmitter, which delivers electrical impulses to treatment targets through implanted electrodes. The DBS modulates the neuronal activities in the brain nucleus for improving physiological responses as long as an electric discharge above the stimulation threshold can be achieved. In an effort to improve the performance of an implanted DBS device, the device size, implementation cost, and power efficiency are among the most important DBS device design aspects. This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency. The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure. The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.

Show MeSH