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Relationship between Diabetic Retinopathy and Subclinical Hypothyroidism: a meta-analysis.

Wu J, Yue S, Geng J, Liu L, Teng W, Liu L, Chen L - Sci Rep (2015)

Bottom Line: Meta-analysis was performed using RevMan 5.1 software.Random-effects meta-analysis indicated a significant association between DR and SCH (odds ratio = 2.13, 95% confidence interval = 1.41 - 3.23, p < 0.001).Based on currently evidence, SCH is probably a significant risk factor for DR.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

ABSTRACT
Several epidemiological studies have found a positive association between diabetic retinopathy (DR) and subclinical hypothyroidism (SCH), but the findings are varied or even contradictory. In the work, we performed a meta-analysis to ascertain the relationship between DR and SCH. We searched relevant studies on the relationship between DR and SCH. All English reports were used Medline, EMbase, Web of Science, Google scholar, and all Chinese ones used CBMDisc (Chinese Biochemical Literature on Disc) and CNKI (China National Knowledge Infrastructure) database. Meta-analysis was performed using RevMan 5.1 software. We obtained eight observational studies. Random-effects meta-analysis indicated a significant association between DR and SCH (odds ratio = 2.13, 95% confidence interval = 1.41 - 3.23, p < 0.001). Based on currently evidence, SCH is probably a significant risk factor for DR.

No MeSH data available.


Related in: MedlinePlus

Flow chart demonstrating those studies that were processed for inclusion in the meta-analysis.
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f1: Flow chart demonstrating those studies that were processed for inclusion in the meta-analysis.

Mentions: We screened 22 articles published from 2010 to 2014. Of these, 14 studies were excluded for the following reasons: reviews, letter and not provide sufficient information for estimating the relationship between DR and SCH. Thus, 8 studies were included in this meta-analysis. Figure 1 was the selection process and reasons for excluding studies.


Relationship between Diabetic Retinopathy and Subclinical Hypothyroidism: a meta-analysis.

Wu J, Yue S, Geng J, Liu L, Teng W, Liu L, Chen L - Sci Rep (2015)

Flow chart demonstrating those studies that were processed for inclusion in the meta-analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4507396&req=5

f1: Flow chart demonstrating those studies that were processed for inclusion in the meta-analysis.
Mentions: We screened 22 articles published from 2010 to 2014. Of these, 14 studies were excluded for the following reasons: reviews, letter and not provide sufficient information for estimating the relationship between DR and SCH. Thus, 8 studies were included in this meta-analysis. Figure 1 was the selection process and reasons for excluding studies.

Bottom Line: Meta-analysis was performed using RevMan 5.1 software.Random-effects meta-analysis indicated a significant association between DR and SCH (odds ratio = 2.13, 95% confidence interval = 1.41 - 3.23, p < 0.001).Based on currently evidence, SCH is probably a significant risk factor for DR.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

ABSTRACT
Several epidemiological studies have found a positive association between diabetic retinopathy (DR) and subclinical hypothyroidism (SCH), but the findings are varied or even contradictory. In the work, we performed a meta-analysis to ascertain the relationship between DR and SCH. We searched relevant studies on the relationship between DR and SCH. All English reports were used Medline, EMbase, Web of Science, Google scholar, and all Chinese ones used CBMDisc (Chinese Biochemical Literature on Disc) and CNKI (China National Knowledge Infrastructure) database. Meta-analysis was performed using RevMan 5.1 software. We obtained eight observational studies. Random-effects meta-analysis indicated a significant association between DR and SCH (odds ratio = 2.13, 95% confidence interval = 1.41 - 3.23, p < 0.001). Based on currently evidence, SCH is probably a significant risk factor for DR.

No MeSH data available.


Related in: MedlinePlus